HTLV Type I and HTLV Type II Infection among Indians and Natives from Argentina

Bouzas, María Belén; Zapiola, Inés; Quiruelas, S.; Gorvein, D.; Panzita, A.; Rey, Jorge; Carnese, F.P.; Corral, Ricardo S.; Perez, C.; Zala, Carlos; Gallo, D; Hanson, Carl V.; Muchinik, G

doi:10.1089/aid.1994.10.1567

Cited by 26 publications

(14 citation statements)

References 14 publications

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“…The other populations are Amerindians and Mestizos, the latter being of mixed Amerindian and European ancestry. HTLV-I in Argentina is found among European descendants and Mestizos [Bouzas et al, 1990;Bouzas et al, 1994;Muchinik et al, 1993]. In addition, a small number of Amerindians in Argentina have been reported to be infected with HTLV-I [Bouzas et al, 1994].…”

Section: Discussionmentioning

confidence: 99%

“…HTLV-I in Argentina is found among European descendants and Mestizos [Bouzas et al, 1990;Bouzas et al, 1994;Muchinik et al, 1993]. In addition, a small number of Amerindians in Argentina have been reported to be infected with HTLV-I [Bouzas et al, 1994]. Considering that Europe is not an endemic focus for HTLV-I [Network, 1996], it is unlikely that ancestors of HTLV-I carriers in Argentina had acquired the virus in Europe and brought it to South America.…”

Section: Discussionmentioning

confidence: 99%

“…In these countries, HTLV-I has been found in various ethnic populations, including whites, blacks, mestizos, mulattoes and Japanese immigrants. It should be noted that the presence of HTLV-I has also been identified among native inhabitants of South America (Amerindians) in Argentina [Bouzas et al, 1994], Colombia [Duenas-Barajas et al, 1992;Zaninovic et al, 1994], Chile [Cartier et al, 1993;Fujiyoshi et al, 1995], and Brazil [Ishak et al, 1995].…”

Section: Introductionmentioning

confidence: 99%

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HTLV-Is in Argentina are phylogenetically similar to those of other South American countries, but different from HTLV-Is in Africa

et al. 1998

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To understand the origin and past dissemination of human T-cell leukemia/lymphotropic virus type I (HTLV-I) in Latin America, we conducted a phylogenetic study of five new HTLV-I isolates from Argentina. We sequenced partial fragments of long terminal repeats (LTR) of the new HTLV-Is, and then the sequences were subjected to a phylogenetic analysis for comparison with other HTLV-Is of various geographical origins. Our results indicated that all the isolates were members of the Cosmopolitan group. Furthermore, most (four out of five isolates) of the new HTLV-Is belonged to the Transcontinental (A) subgroup, the most widespread subgroup of the four subgroups in the Cosmopolitan group. In this subgroup, they were closely related to HTLV-Is found in other South American countries including those of Amerindians, and were different from those found in Africa. In contrast, the remaining one HTLV-I (ARGMF) did not show any clear similarity to known HTLV-I isolates belonging to the Cosmopolitan group. The close similarity of South American HTLV-Is strongly suggests a common origin of the virus in this continent. Our results do not support the proposed idea of recent introduction of HTLV-I into South America as a consequence of the slave trade from Africa, where phylogenetically different HTLV-Is predominate.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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HTLV-Is in Argentina are phylogenetically similar to those of other South American countries, but different from HTLV-Is in Africa

et al. 1998

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“…10,17 Several studies have indicated the presence of HTLV-2 in Matacos and Tobas Indians from Argentina and the Atacama population from Chile. 13,20,22 The seroprevalences of HTLV-1 and HTLV-2 among the Indians of the Amazon region of Peru studied were comparable (0.44% versus 0.44%). Moreover, our finding is the first reported with regard to the presence of HTLV-2 in these aboriginal populations.…”

Section: Discussionmentioning

confidence: 92%

“…4,5 With the exception of the reported HTLV-2 endemic infection in Indians from Argentina, 13,20 there are no other confirmed reports of HTLV-1/2 infection in the aboriginal Indians from the Amazon region of Peru.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of antibody to human T cell lymphotropic virus types 1/2 among aboriginal groups inhabiting northern Argentina and the Amazon region of Peru.

Medeot¹,

Nates²,

Recalde³

et al. 1999

The American Journal of Tropical Medicine and Hygiene

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Abstract. We carried out a seroepidemiologic survey to define the prevalence of human T cell lymphotropic virus types 1/2 (HTLV-1/2) infections among aboriginal populations from isolated regions of northern Argentina and the Amazon region of Peru. Antibodies against HTLV were measured with agglutination tests and confirmed with by an immunofluorescence assay (IFA) and Western blotting. Five (6.94%) of 72 samples from the Tobas Indians in Argentina were positive by the IFA; two samples were typed as HTLV-1 (2.78%), two as HTLV-2 (2.78%), and one (1.39%) could not be typed because it had similar antibody titers against both viruses. No positive samples were found among 84 Andinos Puneños and 47 Matacos Wichis Indians. Seroprevalences of 2.50% (1 of 40) and 1.43% (1 of 70) for HTLV-1 were observed among Wayku and San Francisco communities in the Amazon region of Peru, and seroprevalences of 4.54% (1 of 22) and 2.38% (1 of 42) for HTLV-2 were observed among Boca Colorada and Galilea communities. No serologic evidence of human immunodeficiency virus (HIV) infection was found among the Indians tested. These results indicated the presence of HTLV-1 and HTLV-2 in the indigenous populations of Argentina and Peru. Moreover, the lack of HIV infection indicates that the virus has probably not yet been introduced into these populations.

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Stable human T‐cell lymphotropic virus type 1 (HTLV‐1) subtype a/subgroup a endemicity in Amerindians from Northwest Argentina: A health problem to be resolved

Eirin

Berini

Jones³

et al. 2010

Journal of Medical Virology

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Jujuy province, in Northwest Argentina, is known to be endemic for HTLV-1 infection. Moreover, foci of HTLV-1 associated pathologies have also been described in this region. To gain an insight into the current situation of HTLV-1/2 in this endemic area, a seroprevalence and phylogenetic study was performed among a Kolla community from Abra Pampa city and surroundings. Out of 112 individuals, 11 (9.8%) were confirmed as HTLV-1 positive and no HTLV-2 infection was detected. The phylogenetic analysis of the LTR region showed that all the HTLV-1 sequences belonged to the Cosmopolitan subtype a/transcontinental subgroup A, and were closely related to reference sequences from Peru, Argentina, and the South of Brazil (P = 0.82). Considering the cultural and historical features of this community and in spite of the mandatory detection of anti-HTLV-1/2 antibodies in blood banks since 2005, it would be important to implement new public health measures focused on decreasing HTLV-1 transmission in this endemic area.

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HTLV Type I and HTLV Type II Infection among Indians and Natives from Argentina

Cited by 26 publications

References 14 publications

HTLV-Is in Argentina are phylogenetically similar to those of other South American countries, but different from HTLV-Is in Africa

HTLV-Is in Argentina are phylogenetically similar to those of other South American countries, but different from HTLV-Is in Africa

Prevalence of antibody to human T cell lymphotropic virus types 1/2 among aboriginal groups inhabiting northern Argentina and the Amazon region of Peru.

Stable human T‐cell lymphotropic virus type 1 (HTLV‐1) subtype a/subgroup a endemicity in Amerindians from Northwest Argentina: A health problem to be resolved

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