HTLV seroprevalence in people using HIV pre-exposure prophylaxis in England

Bradshaw, Daniel; Khawar, Arham; Patel, Poorvi; Tosswill, Jennifer; Brown, Colin; Ogaz, Dana; Mason, Emily F.; Osman, Roeann; Mitchell, Helen S.; Dosekun, Olamide; Mora-Peris, Borja; Pickard, Graham; Rayment, Michael; Jones, Rachael; Hopkins, Mark; Williams, Andy; Kingston, Margaret; Machin, Nicholas; Taha, Yusri; Duncan, Sarah; Turner, Neil C.; Gill, Noël; Andrews, Nick; Raza, Mohammad; Tazzyman, Simon; Nori, Achyuta; Cunningham, Emma; Taylor, Graham P.

doi:10.1016/j.jinf.2023.01.033

Cited by 2 publications

(1 citation statement)

References 11 publications

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“…Although none of the 2015 HIV PrEP users were infected, the authors cautioned that up to 75% were men of white ethnicity born in Europe. Hence, persons from HTLV-1 endemic regions were poorly represented (32).…”

Section: Discussionmentioning

confidence: 99%

HTLV infection in persons with sexually transmitted diseases in Spain

Ayerdi,

Benito,

Ortega

et al. 2023

Front. Immunol.

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BackgroundHTLV-1 infection is a neglected disease, despite estimates of 10 million people infected worldwide and producing life-threatening illnesses in 10% of carriers. Sexual transmission is the main route of contagion. However, HTLV-1 is not listed among sexually transmitted infections (STIs).MethodsSerum from all consecutive individuals who had attended six STI clinics across Spain during the last 12 months were tested for HTLV antibodies using a commercial enzyme immunoassay (EIA). Reactive samples were confirmed by immunoblot.ResultsA total of 2,524 samples were examined. The majority (1,936; 76.7%) belonged to men, of whom 676 (34.9%) were men who have sex with men (MSM) receiving HIV pre-exposure prophylaxis. Although native Spaniards predominated (1,470; 58.2%), up to 593 (23.5%) came from Latin America and 139 (5.5%) were African. A total of 26 individuals were initially EIA reactive and immunoblot confirmed 5 as HTLV-1 and 7 as HTLV-2. All but one HTLV-1+ case came from Latin America. Three were men and two were women. Among Latin Americans, the HTLV-1 seroprevalence was 0.67%. In contrast, all seven HTLV-2+ were native Spaniards and former injection drug users, and all but one were HIV+.ConclusionThe rate of HTLV infection among individuals with STIs in Spain is 0.5%, which is greater than in the general population. These results support the introduction of universal HTLV screening in persons who attend clinics for STIs.

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Section: Discussionmentioning

confidence: 99%

HTLV infection in persons with sexually transmitted diseases in Spain

Ayerdi,

Benito,

Ortega

et al. 2023

Front. Immunol.

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Virology, pathogenesis, epidemiology and clinical management of HTLV-1 infection. Proceedings of the 30th HTLV European research network (HERN 2023)

de Mendoza,

Taylor,

Gessain

et al. 2024

NeuroImmune Pharmacology and Therapeutics

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The 30th workshop of the HTLV European Research Network (HERN) was held in Madrid on September 15–16, 2023. Over fifty researchers from Europe and America convened for a two-day conference to update and discuss basic science, epidemiology, clinical management and therapeutics for patients with HTLV-1 infection. Scientific topics addressed included new estimates for HTLV-1 in Europe; impact of antenatal screening on mother-to-child HTLV-1 infections; new insights into the molecular epidemiology of HTLV-1; reports of elite controllers for HTLV-1 infection; role of antiretrovirals as HTLV-1 pre-exposure prophylaxis; and prospects for a HTLV-1 vaccine. The group agreed to submit a formal request to WHO for increasing the global surveillance and awareness of HTLV-1. This viral infection is a potentially life-threatening, neglected condition with neither treatment nor vaccine. At this time, expanding HTLV-1 screening is the most effective way to reduce viral dissemination.

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HTLV seroprevalence in people using HIV pre-exposure prophylaxis in England

Cited by 2 publications

References 11 publications

HTLV infection in persons with sexually transmitted diseases in Spain

HTLV infection in persons with sexually transmitted diseases in Spain

Virology, pathogenesis, epidemiology and clinical management of HTLV-1 infection. Proceedings of the 30th HTLV European research network (HERN 2023)

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