HTLV-3 and HTLV-4 antisense proteins enhance the transactivation potential of several Jun family members through interaction via their bZIP-like domain

Conference Highlights of the 16th International Conference on Human Retrovirology: HTLV and Related Retroviruses, 26–30 June 2013, Montreal, Canada

“…Larocque et al [ 173 ] reported on the further characterization of the HTLV-3 and −4 antisense proteins (APH3 and APH4) that were initially discovered by in silico analysis of their complete genomes and shown in vitro by Larocque et al in 2011 to encode proteins that down-regulate Tax-mediated LTR activation, but which have a distinct subcellular localization [ 174 ]. Unlike the HTLV-1 HBZ, which has a canonical bZIP domain, APH2 (HTLV-2), APH3 and APH4 have an atypical bZIP-like motif with four leucine heptads followed by a leucine octet instead of the five leucine heptads in HBZ [ 169 ].…”