HTLV-1 Tax activates HIV-1 transcription in latency models

Geddes, Victor Emmanuel Viana; José, Diego Pandeló; Leal, Fábio E.; Nixon, Douglas F.; Tanuri, Amílcar; Aguiar, Renato Santana

doi:10.1016/j.virol.2017.01.014

Cited by 17 publications

(8 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Indeed, Tax enhances NF-κB activity [ 147 ], which in turn recognizes responsive elements on the HIV-1 promoter [ 148 ]. This observation was later supported by another study, in which Tax promoted HIV-1 transcription in latent CD4+ T-cells [ 149 ]. In contrast, a daily treatment with recombinant Tax protein added to the culture medium of in vitro HIV-1-infected PBMCs (Peripheral Blood Mononuclear Cells) showed opposite effects, with an inhibition of HIV-1 replication up to 14 days after infection [ 150 ].…”

Section: Hiv-1 and Htlv-1 Co-infectionssupporting

confidence: 53%

HTLV-1, the Other Pathogenic Yet Neglected Human Retrovirus: From Transmission to Therapeutic Treatment

Futsch

Mahieux

Dutartre

2017

Viruses

View full text Add to dashboard Cite

Going back to their discovery in the early 1980s, both the Human T-cell Leukemia virus type-1 (HTLV-1) and the Human Immunodeficiency Virus type-1 (HIV-1) greatly fascinated the virology scene, not only because they were the first human retroviruses discovered, but also because they were associated with fatal diseases in the human population. In almost four decades of scientific research, both viruses have had different fates, HTLV-1 being often upstaged by HIV-1. However, although being very close in terms of genome organization, cellular tropism, and viral replication, HIV-1 and HTLV-1 are not completely commutable in terms of treatment, especially because of the opposite fate of the cells they infect: death versus immortalization, respectively. Nowadays, the antiretroviral therapies developed to treat HIV-1 infected individuals and to limit HIV-1 spread among the human population have a poor or no effect on HTLV-1 infected individuals, and thus, do not prevent the development of HTLV-1-associated diseases, which still lack highly efficient treatments. The present review mainly focuses on the course of HTLV-1 infection, from the initial infection of the host to diseases development and associated treatments, but also investigates HIV-1/HTLV-1 co-infection events and their impact on diseases development.

show abstract

Section: Hiv-1 and Htlv-1 Co-infectionssupporting

confidence: 53%

HTLV-1, the Other Pathogenic Yet Neglected Human Retrovirus: From Transmission to Therapeutic Treatment

Futsch

Mahieux

Dutartre

2017

Viruses

View full text Add to dashboard Cite

show abstract

“…Tax protein is encoded by HTLV-1 33 . It promotes the activation of P-TEFb, releasing CDK9 and Cyclin T1 from inactive forms in latently infected CD4+ T-cells, promoting transcription elongation and reactivation of latent HIV-1 34 .…”

Section: Mechanisms Of Co-infections Htlv-1 Tax Oncoprotein Expression Enhances Hiv-1 Replicationmentioning

confidence: 99%

Clinical Approaches of HIV-1/HTLV-1 Co-infection Still Keep their Mysteries

Rizkallah¹,

Mahieux²,

Dutartre³

2019

J Infectiology

View full text Add to dashboard Cite

“…Indeed, simultaneously infected patients by both viruses with CD4 þ T counts greater than 200 cells/mm 3 are more exposure to have other opportunistic infections as compared with HIV mono-infected patients who have similar CD4 þ T counts [44]. Studies have reported that higher mortality and shortened survival rates were accompany with co-infected individuals more than mono-infected individuals [45]. Considering the natural history of HIV, many researchers have noted that co-infection with HIV and HTLV-I can accelerate the clinical progression to AIDS.…”

Section: Introductionmentioning

confidence: 99%

“…Considering the natural history of HIV, many researchers have noted that co-infection with HIV and HTLV-I can accelerate the clinical progression to AIDS. On the other hand, HIV can adjust HTLV-I expression in co-infected individuals which leads them to a higher risk of developing HTLV-I related diseases such as ATL and TSP/HAM [40,41,45].…”

Section: Introductionmentioning

confidence: 99%

Modeling and analysis of a within-host HIV/HTLV-I co-infection

Ełaiw

AlShamrani

2021

Bol. Soc. Mat. Mex.

View full text Add to dashboard Cite

Human immunodeficiency virus (HIV) and human T-lymphotropic virus type I (HTLV-I) are two retroviruses that attack the T cells and impair their functions. Both HIV and HTLV-I can be transmitted between individuals through direct contact with certain body fluids from infected individuals. Therefore, a person can be co-infected with both viruses. HIV causes acquired immunodeficiency syndrome (AIDS), while HTLV-I is the causative agent for adult T-cell leukemia (ATL) and HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Several mathematical models have been developed in the literature to describe the within-host dynamics of HIV and HTLV-I mono-infections. However, modeling a within-host dynamics of HIV/HTLV-I co-infection has not been involved. The present paper is concerned with the formulation and investigation of a new HIV/HTLV-I co-infection model under the effect of Cytotoxic T lymphocytes (CTLs) immune response. The model describes the interaction between susceptible T cells, silent HIV-infected cells, active HIV-infected cells, silent HTLV-infected cells, Tax-expressing HTLV-infected cells, free HIV particles, HIV-specific CTLs and HTLV-specific CTLs. The HIV can spread by virus-to-cell transmission. On the other side, HTLV-I has two modes of transmission, (i) horizontal transmission via direct cell-to-cell contact through the virological synapse, and (ii) vertical transmission through the mitotic division of Tax-expressing HTLV-infected cells. The well-posedness of the model is established by showing that the solutions of the model are nonnegative and bounded. We define a set of threshold parameters which govern the existence and stability of all equilibria of the model. We explore the global asymptotic stability of all equilibria by utilizing Lyapunov function and Lyapunov–LaSalle asymptotic stability theorem. We have presented numerical simulations to justify the applicability and effectiveness of the theoretical results. In addition, we evaluate the effect of HTLV-I infection on the HIV dynamics and vice versa.

show abstract

HTLV-1 Tax activates HIV-1 transcription in latency models

Cited by 17 publications

References 31 publications

HTLV-1, the Other Pathogenic Yet Neglected Human Retrovirus: From Transmission to Therapeutic Treatment

HTLV-1, the Other Pathogenic Yet Neglected Human Retrovirus: From Transmission to Therapeutic Treatment

Clinical Approaches of HIV-1/HTLV-1 Co-infection Still Keep their Mysteries

Modeling and analysis of a within-host HIV/HTLV-I co-infection

Contact Info

Product

Resources

About