HTLV-1 Myelopathy in Kuwait: A Report of 2 Patients and Review of Possible Links

Farah, Solange Bento; Khan, Rashid Ahmed; Voevodin, Alexander; Mufti, Samiya; Rudwan, M.; Hussein, Jassim M.; Ravindran, Mithunan

doi:10.1159/000157391

Cited by 5 publications

(6 citation statements)

References 15 publications

(17 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Later it has been shown that the high prevalence of HTLV-I infection is also characteristic for the Muslim population of Mashhad [23]. The cases of HTLV-I infection and HTLV-I-associated diseases were also described in Iraq [24] and, recently, in Kuwait [25,26]. After that several more cases of HAM/TSP and 2 cases of ATTL have been diagnosed in Kuwait [27, unpublished].…”

Section: Discussionmentioning

confidence: 99%

Seroprevalence of Human T-Cell Leukemia/Lymphoma Virus Type I and Type II (HTLV-I/HTLV-II) Infection among Volunteer Blood Donors in Kuwait

et al. 1999

View full text Add to dashboard Cite

Objective: The human T-cell leukemia/lymphoma virus type I (HTLV-I) is an etiologic agent of adult T-cell leukemia/lymphoma and tropical spastic paraparesis. One of the major routes of transmission of the virus is through blood transfusion. The aim of this study was to determine the prevalence of HTLV-I infection in volunteer blood donors in Kuwait. Methods: A donation of 97,602 blood units in Kuwait from March 1995 to October 1997 was tested for antibodies against HTLV-I and related virus (HTLV-II). The testing was carried out in three steps: first screening by enzyme immunoassay (EIA) for anti-HTLV-I/II, second testing of initially positive samples by the EIA and final confirmation of true positives by Western blot. Results: Twenty-one HTLV-I-positive donors have been identified (7 Kuwaitis, 5 Indians, 4 Iranians, 2 Bedouins, 1 Omani, 1 Egyptian and 1 Filipino). None of the EIA-reactive samples was positive for HTLV-II by Western blot. The frequency of HTLV-I-positive blood donations was: 1:4,648 and the infection was significantly more prevalent among Indians and Iranians. Conclusion: The prevalence of HTLV-I infection in blood donors in Kuwait is one of the highest in the world and compulsory screening of blood for HTLV-I is fully justified.

show abstract

Section: Discussionmentioning

confidence: 99%

Seroprevalence of Human T-Cell Leukemia/Lymphoma Virus Type I and Type II (HTLV-I/HTLV-II) Infection among Volunteer Blood Donors in Kuwait

et al. 1999

View full text Add to dashboard Cite

show abstract

“…HTLV-I was also described in Iraq, southern region of which had close historical ties with Mashhad; the latter is a holy city for Shiite Muslims and southern Iraq is populated mainly by Shiites. HTLV-I was also described in Kuwait, again in the families originating from southern Iraq and specifically from the city of Najaf which for centuries had close ties with Mashhad [Voevodin et al, 1995;Farah et al, 1996]. Thus, the pattern had been emerging suggesting that a cluster of HTLV-I infection in the Mashhadi Jews is not an isolated one, but just one of the ''derivatives'' of the same lineage of cosmopolitan HTLV-I which had spread throughout the Middle East from Mashhad.…”

Section: Discussionmentioning

confidence: 97%

“…Later, it was also shown that the high prevalence of HTLV-I infection is also characteristic of the Muslim population of Mashhad [Kitze et al, 1992;Gabarre et al, 1993;Vidal et al, 1994;PuccioniSohler et al, 1995;Safai et al, 1996, Farid et al, 1995. Cases of HTLV-I infection and HTLV-I-associated diseases have also been described in Iraq [Denic et al, 1990] and, recently, in Kuwait [Voevodin et al, 1995;Farah et al, 1996;Al-Mufti et al, 1996].…”

Section: Introductionmentioning

confidence: 97%

Common origin of human T-lymphotropic virus type-I from Iran, Kuwait, Israel, and La Réunion Island

Voevodin

Gessain

1997

J. Med. Virol.

View full text Add to dashboard Cite

We found previously that Kuwaiti HTLV-I isolates had two nucleotide substitutions in the most frequently sequenced regions of HTLV-I genome, namely: T-->C 4783 in the pol and T-->C 6569 the env genes. These substitutions were observed rarely in other HTLV-I isolates and seemed to be good markers of the HTLV-I lineage, the "epicentre" of which was located in Mashhad, Iran. To test this hypothesis we sequenced the fragments of HTLV-I genome including sites 4783 and 6569 from seven isolates obtained from the Iranians either living in (five isolates) or originating from (two isolates) Mashhad. RFLP-based tests were also designed and used for typing of the substitutions. All seven isolates were positive for T-->C 4783 and six, from which env fragment was amplifiable, were also positive for T-->C 6569. It is highly probable that all the isolates from Mashhadi Jews belong to the same HTLV-I lineage, although they were not typed yet for the presence of T-->C 6569 substitution. Only 2 "non-Middle Eastern" HTLV-1, both from La Réunion Island were positive for both of the substitutions. Another possible member of Mashhadi lineage of HTLV-I is one isolate from southern India and two isolates from the American Indians, British Columbia, Canada. The determination of the T-->C 4783 and T-->C 6569 markers in HTLV-I isolates of different geographical/ethnic origin may be useful for the reconstruction of the routes of HTLV-I spread from the Middle East and/or Indian subcontinent to other regions of the world and, possibly, for gaining insights into the origin of HTLV-I in Asia.

show abstract

“…Also, no Saudi donor had tested positive in previous studies, 17,18 except for nine samples which tested positive by WB from 33,908 Saudi donors screened in the Eastern Province, which has a low prevalence rate of 0.022%. 19 The majority of EIA-reactive results 14,19 were indeterminate by Western blot. The samples tested again by WB still gave the same results.…”

Section: Discussionmentioning

confidence: 99%

“…11 HTLV-I is now recognized to occur worldwide, although it is characteristically endemic in Japan, the Caribbean, Southern Italy, New Guinea, Africa, and the Seychelles, 12 as well as in several countries in the Middle East. [13][14] In the present study, we took sera from volunteer Saudi blood donors and hemodialysis patients over a threeyear period to determine the prevalence of HTLV-I/II among Saudi blood donors, and to examine the cost effectiveness of HTLV screening in Saudi blood banks.…”

mentioning

confidence: 99%

Prevalence of Antibodies to Human T-Lymphotropic Virus Types I and II among Saudi Arabian Blood Donors

Jaouni

2000

Ann Saudi Med

View full text Add to dashboard Cite

HTLV-1 Myelopathy in Kuwait: A Report of 2 Patients and Review of Possible Links

Cited by 5 publications

References 15 publications

Seroprevalence of Human T-Cell Leukemia/Lymphoma Virus Type I and Type II (HTLV-I/HTLV-II) Infection among Volunteer Blood Donors in Kuwait

Seroprevalence of Human T-Cell Leukemia/Lymphoma Virus Type I and Type II (HTLV-I/HTLV-II) Infection among Volunteer Blood Donors in Kuwait

Common origin of human T-lymphotropic virus type-I from Iran, Kuwait, Israel, and La Réunion Island

Prevalence of Antibodies to Human T-Lymphotropic Virus Types I and II among Saudi Arabian Blood Donors

Contact Info

Product

Resources

About