HSV-2 antibodies in female sex workers in Vietnam

O’Farrell, Nigel; Thuong, Nguyen Vu; Nghia, Khuu Van; Tram, Luong Thu; Long, Nguyễn Thành

doi:10.1258/095646206778691176

Cited by 10 publications

(10 citation statements)

References 9 publications

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“…The HSV-2 prevalence differential parallels the differential in invasive cervical cancer incidence (26.0/100,000/year in HCMC, 6.3/100,000 in Hanoi18,19), for which HSV-2 may be a cofactor with high-risk HPV infection20. Also, HSV-2 seroprevalence in female sex workers is higher in southern provinces (Dong Thap 32.3%, An Giang 33.3% and Kien Giang 29.9%) than in a northern border area (Lai Chau 5.0%)21. Such regional differences could reflect South Vietnam’s greater mid-20 th century wartime exposure to social, economic, and political disruption, internal migration, and U.S. military personnel and contractors.…”

Section: Discussionmentioning

confidence: 99%

Herpes Simplex Virus Type-2 Seropositivity Among Ever Married Women in South and North Vietnam: A Population-Based Study

Le¹,

Schoenbach²,

Herrero³

et al. 2009

Sexually Transmitted Diseases

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Objective To investigate herpes simplex virus type–2 (HSV-2) seropositivity and associated risk factors in Vietnamese women. Methods Cross-sectional study with personal interviews and gynecological examinations among population-based samples of ever married women, aged 15–69 years, living in Ho Chi Minh City (HCMC) and Hanoi in 1997. Type-specific IgG antibodies against HSV-2 were detected using HerpeSelect ELISA (Focus Diagnostics). Adjusted prevalence ratios were estimated with log-binomial regression. Results HSV-2 seroprevalence was higher in 1,106 women from HCMC (30.8%, 95% CI: 28.1–33.4, age-standardized to 2000 world standard population) than in 1,170 women from Hanoi (8.8%, 95% CI: 7.1–10.5). In HCMC, HSV-2 seroprevalence was higher for women who were not married, HPV DNA positive, current hormonal contraceptive users, or had a history of multiple sexual partners or spontaneous abortion. HCMC seroprevalence was inversely associated with educational attainment, age at first intercourse, and age at first pregnancy. In the multivariable model for HCMC, a trend of increasing HSV-2 seroprevalence with age was observed, and prevalence ratios were nearly identical to age-adjusted prevalence ratios for marital status, age at first pregnancy, and HPV DNA positivity. Conclusion HSV-2 was notably less prevalent in Hanoi than HCMC, where it was associated with traditional HSV-2 risk factors. These results are likely explained by socio-cultural, historical, economic, and demographic factors related to urban-rural and regional differences. Future population-based studies should include men and never-married women as a next step toward obtaining a more nearly complete picture of HSV-2 epidemiology in Vietnam.

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Section: Discussionmentioning

confidence: 99%

Herpes Simplex Virus Type-2 Seropositivity Among Ever Married Women in South and North Vietnam: A Population-Based Study

Le¹,

Schoenbach²,

Herrero³

et al. 2009

Sexually Transmitted Diseases

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“…The results of the first (baseline) survey among 911 FSWs held during December 2002-January 2003 are reported elsewhere. [11][12][13][14] All participants in the baseline survey were offered azithromycin 2 g stat dose to cover possible cervical infections with gonorrhoea and CT. In December 2004, 982 FSWs were sampled from the same provincial districts as the first survey.…”

Section: Sti/hiv Surveysmentioning

confidence: 99%

“…[11][12][13][14] Selected social, demographical and sexual behaviours among FSWs and their partners in 2004 In all, 982 people participated in the final survey, 99% of whom agreed to give blood and 97% agreed to give urine for testing. Very few of those who were asked to participate declined.…”

Section: Baseline Surveymentioning

confidence: 99%

Impact of a community sexually transmitted infection/HIV intervention project on female sex workers in five border provinces of Vietnam

Thuong

Nghia

Hau

et al. 2007

Sexually Transmitted Infections

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Objectives: To determine changes in the prevalence of sexually transmitted infection (STI)/HIV in female sex workers (FSWs) after a community HIV prevention intervention project in five border provinces of Vietnam. Methods: The project focused on providing user-friendly STI services for FSWs using mobile teams operating at multiple sites depending on local client preferences. 911 FSWs were enrolled at baseline and 982 in the exit survey. Study participants were interviewed about sociodemographic characteristics, sexual behaviour, history of STIs and selected features of their husbands or cohabiting partners, and were tested for STIs. Results: The overall prevalence rates of HIV, syphilis, herpes simplex virus 2 (HSV-2) antibodies, gonorrhoea (GC), Chlamydia trachomatis (CT), and GC and/or CT among FSWs in the five border provinces in 2004 were 3.6%, 12.9%, 24.9%, 2.9%, 9.1% and 11.3%, respectively. Compared with baseline values, GC and/or CT decreased significantly from 19.9% to 11.3%, GC from 10.7% to 2.9% and CT from 11.9% to 9.1%. HIV decreased from 4.5% to 3.6%, and HSV-2 antibodies from 27.7% to 24.9%. After adjustment for possible confounders, a significant overall decrease in having GC and/or CT (OR = 0.46, 95% CI 0.33 to 0.65; p,0.001) and GC alone (OR = 0.22, 95% CI 0.13 to 0.37; p,0.001) was found, and the overall prevalence of syphilis increased significantly (OR = 1.55, 95% CI 1.11 to 2.17 p = 0.011). A marked increase in syphilis from 1.0% to 14.1% was identified in the Lai Chau province. Conclusions: Implementation of the project was associated with a reduction in GC and/or CT infections in FSWs, more so with GC than with CT. A notable increase in syphilis in Lai Chau was identified. HIV/STI interventions in FSWs can be implemented by government services and should be intensified and expanded to other provinces.

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“…3 There are little data on HSV infection rates in Vietnam, but 1 study of female sex workers in 3 Mekong Delta provinces showed HSV-2 antibody prevalence rates of 30% to 33%. 4 Atypical presentations of herpes are not uncommon in immunocompromised patients. 4 Ulcers can appear in single or multiple locations and are more likely to become chronic and extensive.…”

Section: Discussionmentioning

confidence: 99%

“…4 Atypical presentations of herpes are not uncommon in immunocompromised patients. 4 Ulcers can appear in single or multiple locations and are more likely to become chronic and extensive. Herpes simplex virus lesions in the HIVinfected patient can usually be treated with acyclovir, although acyclovir-resistant HSV has been reported.…”

Section: Discussionmentioning

confidence: 99%