HSV-1 and HSV-2 in herpes simplex encephalitis: A study of sixty-four cases in the United Kingdom

Dennett, C; Cleator, Graham M.; Klapper, Paul E.

doi:10.1002/(sici)1096-9071(199709)53:1<1::aid-jmv1>3.0.co;2-4

Cited by 55 publications

(23 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…o r g and adult HSV-E is due to HSV-1 in 99% of patients. 6 While cases of neonatal HSV-E due to HSV-1 are uncommon, they may occur via vertical transmission during a primary maternal infection of HSV-1. In cases of neonatal HSV-E due to HSV-2 exposure during delivery, a latency of typically 11-17 days following delivery has been described prior to clinical presentation.…”

Section: Original Articlementioning

confidence: 99%

Neonatal Herpes Encephalitis: A Case Series and Review of Clinical Presentation

Toth

Harder

Yager

2003

Can. j. neurol. sci.

View full text Add to dashboard Cite

36Neonatal herpes simplex virus encephalitis (HSV-E) was first described in the 1930s, 1 centuries after descriptions of the adult form of HSV-E were available. Three decades later, viral cultures and immunologic techniques permitted herpes simplex virus-1 (HSV-1) to be distinguished from herpes simplex virus-2 (HSV-2).2 These techniques allowed for clearer definitions of epidemiology and pathogenesis of HSV-1 and HSV-2 infections.3 The prognosis for the two viral types varies as well, with HSV-1 infection associated with a better overall prognosis than with HSV-2 as a cause of neonatal encephalitis. Five male and four female infant patients were identified. At a mean age of presentation of 24±20 days, seizures occurred in six neonates, lethargy in six neonates, temperature changes in five neonates, and apnea in three neonates. Examination of CSF demonstrated an initial monocytosis or lymphocytosis, elevated CSF protein and depressed CSF glucose in 100% of patients. Electroencephalography (EEG) was abnormal in 100% of patients. Initial computerized tomography was abnormal in 55% of patients. Clinical follow-up over an average of two years demonstrated developmental delay in four patients and upper motor neuron findings in four patients. No patients suffered from postencephalitic epilepsy or mortality. Conclusions: Neonatal HSV encephalitis most commonly presents with seizures, lethargy, and dysthermia. Cerebrospinal fluid testing and EEG have 100% sensitivity in cases with laboratory confirmation of HSV presence. Improvements in morbidity and mortality as compared to previous reports may relate to better recognition of this illness and acyclovir therapy. The lack of postinfection epilepsy in our series may also relate to better recognition and acyclovir therapy within this series of patients. Seuls les patients dont le tableau clinique était conforme à celui de l'encéphalite à VHS et chez qui la présence du VHS avait été démontrée soit par une culture positive du liquide céphalo-rachidien (LCR), une amplification en chaîne par polymérase positive du LCR ou des immunoglobulines G anti-VHS positives dans le sang ont été sélectionnés. Résultats: Neuf bébés, soit cinq garçons et quatre filles, ont été identifiés. L'âge moyen de présentation était de 24 ± 20 jours et les symptômes initiaux ont été des convulsions chez six, de la léthargie chez six, des variations de température chez cinq et de l'apnée chez trois. L'examen du LCR a montré initialement une monocytose ou une lymphocytose, une élévation des protéines et une baisse du glucose chez tous les patients. L'électroencéphalogramme était anormal chez tous. La tomodensitométrie initiale était anormale chez 55% des patients. Le suivi clinique sur une période moyenne de deux ans a montré un retard de développement chez quatre patients et des anomalies du neurone moteur supérieur chez quatre patients. Aucun patient ne présentait de l'épilepsie postencéphalitique et il n'y a eu aucun décès. Conclusions: L'encéphalite néonatale à VHS se manifeste la plupart du temps pa...

show abstract

Section: Original Articlementioning

confidence: 99%

Neonatal Herpes Encephalitis: A Case Series and Review of Clinical Presentation

Toth

Harder

Yager

2003

Can. j. neurol. sci.

View full text Add to dashboard Cite

show abstract

“…Die HSE wird, mit Ausnahme der Erkrankung im Säuglingsalter, ganz über-wiegend durch das Herpes-simplex-Virus Typ 1 (HSV-1) hervorgerufen [13,52]. Der Typ 2 des Virus (HSV-2) löst selten eine meist benigne ZNS-Infektion beim gesunden Erwachsenen, bei immunsupprimierten Patienten aber vereinzelt schwere Meningoenzephalitiden aus [31].…”

Section: Grundlagenunclassified

Herpes–simplex–Virus–Typ–1–Enzephalitis

et al. 2004

View full text Add to dashboard Cite

show abstract

“…In the mid 1960s, Nahmias and Dowdle found two distinct antigenic type of HSV, as HSV type-1 and HSV type-2 (Nahmias & Dowdle, 1968). The HSE, observed in adults, is caused by HSV type-1 predominantly (Dennett et al, 1997;. HSV type-2 is rarely seen in healthy adults and usually causes benign CNS infection, whereas severe meningoencephalitis is seen in immunosuppressed individuals (Mommeja-Marin et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

Herpes Simplex Type 1 Encephalitis

Sarica¹

2011

Non-Flavivirus Encephalitis

View full text Add to dashboard Cite

HSV-1 and HSV-2 in herpes simplex encephalitis: A study of sixty-four cases in the United Kingdom

Cited by 55 publications

References 19 publications

Neonatal Herpes Encephalitis: A Case Series and Review of Clinical Presentation

Neonatal Herpes Encephalitis: A Case Series and Review of Clinical Presentation

Herpes–simplex–Virus–Typ–1–Enzephalitis

Herpes Simplex Type 1 Encephalitis

Contact Info

Product

Resources

About