HSR20-113: Diabetes Complications and Risks of Breast Cancer Recurrence Among Older Women

Zhou, Jifang; Asfaw, Alemseged Ayele; Nabulsi, Nadia A.; Mukand, Nita; Lee, In-Young; Ko, Naomi; Boudreau, Denise M.; Calip, Gregory Sampang

doi:10.6004/jnccn.2019.7475

Cited by 1 publication

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“…Algorithms developed by Boston University School of Public Health for the conversion of SF-36 to VR-12 scores were used in the SEER-MHOS data resource to account for changes in the survey instrument over time [29]. The VR-12 is a brief, generic health survey comprised of 12 items that correspond to eight principal physical and mental health domains including physical functioning (PF), role limitations due to physical problems (RP), bodily pain (BP), general health perceptions (GH), general mental health (MH), role limitations due to emotional problems (RE), social functioning [30], and vitality (VT) [32]. The items can be summarized into two scores, a mental component summary (MCS) score and physical component summary (PCS) score.…”

Section: Methodsmentioning

confidence: 99%

The association between physical health-related quality of life, physical functioning, and risk of contralateral breast cancer among older women

Mukand

Nabulsi

et al. 2021

Breast Cancer

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Background Physical limitations prior to cancer diagnosis may lead to suboptimal health outcomes. Our objective was to evaluate the impacts of poor physical health-related quality of life (HRQOL) and physical functioning (PF) on the risk of contralateral breast cancer (CBC). Methods We performed a nested case-control study of women with invasive unilateral breast cancer (UBC) who did not receive prophylactic contralateral mastectomy using the Surveillance, Epidemiology and End Results Medicare Health Outcomes Survey data resource. Among 2938 women aged ≥ 65 years diagnosed with first stage I-III UBC between 1997 and 2011, we identified 100 subsequent CBC cases and 915 matched controls without CBC using incidence density sampling without replacement. Pre-diagnosis physical HRQOL and PF were determined using Medical Outcomes Trust Short Form-36 (SF-36)/Veterans Rand 12-Item Health Survey (VR-12) responses within 2 years prior to first UBC diagnosis. We estimated adjusted odds ratios (OR) and 95% confidence intervals (CI) using conditional logistic regression models. Results Cases and controls were similar with respect to comorbidities, stage, surgery, and radiation treatments, but differed by hormone receptor status (ER/PR-negative, 23% and 11%, respectively) of first UBC. Cases had modestly lower mean pre-diagnosis physical HRQOL (− 1.8) and PF (− 2.2) scores. In multivariable models, we observed an increased CBC risk associated with low physical HRQOL (lowest vs. highest quartile, OR = 1.8; 95% CI 0.8-4.3), but CIs included 1.0. Low PF was associated with a 2.7-fold (95% CI 1.1-6.7) increased CBC risk. Conclusions Findings indicate that low physical HRQOL, specifically poor PF, is associated with CBC risk. Efforts to understand and minimize declines in PF post-breast cancer are well motivated.

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Section: Methodsmentioning

confidence: 99%