HSP90-stabilized proteins as therapeutic targets in cancer

Abstract

ABBREVIATIONS°C degree celsius 17AAG (Tanespimycin) 17-(allylamino)geldanamycin ADP adenosine diphosphate AHA1 activator of 90 kDa heat shock protein ATPase homolog 1 AKT RAC-alpha serine/threonine-protein kinase AMPK 5'-AMP-activated protein kinase catalytic subunit alpha-1 AOM azoxymethane AP1 activating protein 1 APC adenomatosis polyposis coli ATP adenosine triphosphate BAX BCL2 associated X protein CCL2 C-C motif chemokine ligand 2 CCL5 C-C motif chemokine ligand 5 CCND1 cyclin D1 CD3 cluster of Differentiation 3 CD31 cluster of Differentiation 31 CD44 cluster of Differentiation 44 CD68 cluster of Differentiation 68 CD74 cluster of Differentiation 74 CDC37 cell division cycle 37 CDKN1A cyclin dependent kinase inhibitor 1A CDKN2A cyclin dependent kinase inhibitor 2A CHIP c-terminus of Hsc70-interacting protein CHX cycloheximide cJUN AP1 transcription factor subunit Co-IP co-immunoprecipitation con control CRC colorectal cancer cre cyclization recombinase ABBREVIATIONS VIII CRISPR/Cas9 Clustered regularly interspaced palindromic repeats/ CRISPR-associated protein 9 CTNNB1 catenin beta-1 CXCR2 C-X-C motif chemokine receptor 2 CXCR4 C-X-C motif chemokine receptor 4 CXCR7 C-X-C motif chemokine receptor 7 DAPI 4′,6-diamidino-2-phenylindole DBD DNA binding domain DMSO dimethylsulfoxide DNA deoxyribonucleic acid DSS dextran sodium sulfate ERK extracellular regulated MAP kinase ERT2 estrogen receptor 2 FDA Food and Drug Administration