HSP70 as a biomarker of the thin threshold between benefit and injury due to physical exercise when exposed to air pollution

What artificial intelligence knows about 70 kDa heat shock proteins, and how we will face this ChatGPT era

“…The combination of fake references and hallucinations may result in suspicious information. For example, one answer was “The authors also reported that the eHSP70-to-iHSP70 ratio was increased after exercise training, suggesting that chronic exercise may promote a more favorable balance between intracellular and extracellular HSP70.” In fact, different studies have demonstrated that the eHSP70-to-iHSP70 ratio is increased in chronic diseases (Costa-Beber et al 2020 and 2021 ; Oliveira et al 2022 ; Seibert et al 2022 ), with exercise as a non-pharmacological strategy to decrease this ratio (Heck et al 2017 ; Mai et al 2017 ), which contradicts the response of ChatGPT. Therefore, at present, AI cannot substitute for human revision.…”

Resolution of inflammation in chronic disease via restoration of the heat shock response (HSR)

“…This is possible because eHSP70/iHSP70 ratios between plasma and PBMC reflect eHSP70/iHSP70 ratios between plasma and (metabolic) tissues . 24 , 25 , 181 , 187 , 191 , 207 , 209 , 210 , 211 , 212 , 213 , 214 , 215 , 216 …”

“…In protocol #2 , we compare both HSP70 in PBMC (intracellular, iHSP70) and supernatant HSP70 (extracellular, eHSP70), after 6 h from the beginning of the 2-h incubation period. 216 We have used the same protocol to compare the HSR in the human ovarian cortex obtained by closed metal container vitrification or the slow-freezing technique of cryopreservation. 221 …”

Heat shock proteins as potential biomarkers of heart failure

“…Биологическая роль БТШ заключается в защите процессов синтеза белка, а также подержании целостности структуры клеточных белков. Имеются данные об участии БТШ70 в процессах восстановления дезоксирибонуклеиновой кислоты [41].…”