HSP60 mimetic peptides from Mycobacterium leprae as new antigens for immunodiagnosis of Leprosy
Mayara Ingrid Sousa Lima,
Meydson Benjamim Carvalho Corrêa,
Emilly Caroline dos Santos Moraes
et al.
Abstract:The early diagnosis of leprosy serves as an important tool to reduce the incidence of this disease in the world. Phage display (PD) technology can be used for mapping new antigens to the development of immunodiagnostic platforms. Our objective was to identify peptides that mimic Mycobacterium leprae proteins as serological markers using phage display technology. The phages were obtained in the biopanning using negative and positive serum from household contacts and leprosy patients, respectively. Then, the pep… Show more
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