HSP60 expression during carcinogenesis: Where is the pilot?

Cappello, Francesco; Zummo, Giovanni

doi:10.1016/j.prp.2006.02.002

Cited by 4 publications

(3 citation statements)

References 8 publications

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“…For example, elevated levels of this protein in tumor cells have been linked to: (i) ability to survive apoptotic stimuli; (ii) loss of replicative senescence; (iii) uncontrolled proliferation; and (iv) neoplastic transformation. 17,[43][44][45] In addition, it has been shown in in vitro experiments that Hsp60 knockdown arrests osteosarcoma cell growth. 15 Likewise, inhibition of Hsp60 expression by short hairpin RNA plasmids stopped tumor cell growth.…”

Section: Hsp60 and Tumor Growthmentioning

confidence: 99%

Hsp60 expression, new locations, functions, and perspectives for cancer diagnosis and therapy

Cappello

Macario²,

Marasà³

et al. 2008

Cancer Biology & Therapy

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Hsp60 in eukaryotes is considered typically a mitochondrial chaperone (also called Cpn60) but in the last few years it has become clear that it also occurs in the cytosol, the cell surface, the extracellular space, and in the peripheral blood. Studies with prokaryotic models have shown that Hsp60 plays a role in assisting nascent polypeptides to reach a native conformation, and that it interacts with Hsp10 (which also resides in the mitochondria and is also named Cpn10). In addition to its role in polypeptide folding in association with Hsp10, other functions and interacting molecules have been identified for Hsp60 in the last several years. Some of these newly identified functions are associated with carcinogenesis, specifically with tumor cell survival and proliferation. Thus, assessing the levels of Hsp60 in tumor cells and in sera of cancer patients is becoming an attractive area of investigation aiming at the development of means for practical applications in clinical oncology. Since Hsp60 participates in extracellular molecular interactions and cell signalling and also in key intracellular pathways of some types of tumor cells, the idea of using Hsp60 in anti-cancer therapy (chaperonotherapy) is being investigated. The Hsp could be used either as an anticancer agent alone or in combination with tumor antigens, or as target for anti-chaperone compounds. In this article, a brief review is presented of representative research efforts aimed at assessing Hsp60 in a variety of tumors with the purpose of illustrating possible implications and applications for making early and differential diagnoses, assessing prognosis, monitoring response to treatment, and for developing novel anti-cancer strategies.

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Section: Hsp60 and Tumor Growthmentioning

confidence: 99%

Hsp60 expression, new locations, functions, and perspectives for cancer diagnosis and therapy

Cappello

Macario²,

Marasà³

et al. 2008

Cancer Biology & Therapy

Self Cite

241

201

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“…Since it was realized that chaperones may be at the center of mechanisms that cause cell damage, tissue abnormalities, and disease, it was also realized that therapeutic means ought to use chaperones either as remedies or as targets for treatment agents [2], and we, in our research, have focused on the chaperonin HSP60 (also termed Cpn60 or, accordingly to the new terminology, HSPD1) [26][27][28]. This therapeutic approach, involving chaperones as central players or targets, i.e., chaperonotherapy, includes two modalities.…”

Section: Chaperonopathies and Chaperonotherapymentioning

confidence: 99%

Chaperonotherapy for Alzheimer’s Disease: Focusing on HSP60

Cappello

Gammazza

Vilasi

et al. 2015

Heat Shock Proteins

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“…Heat shock proteins (HSPs) are a group of highly conserved proteins that help protect cells from various type of stress (heat, cold, and abnormal levels of glucose or oxygen). ey help the correct folding of many proteins and protect cells from deleterious consequences as protein misfolding, premature degradation, or aggregation [3][4][5][6]. HSPs normally support other protein functions in normal cells, but they may be present at high levels in cancer cells.…”

Section: Introductionmentioning

confidence: 99%

Role of HSP60/HSP10 in Lung Cancer: Simple Biomarkers or Leading Actors?

Fucarino

Pitruzzella

2020

Journal of Oncology

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Cancers are one of the major challenges faced by modern medicine both because of their impact in terms of the amount of cases and of the ineffectiveness of therapies used today. A concrete support to the fight against them can be found in the analysis and understanding of the molecular mechanisms involving molecular chaperones. In particular, HSP60 and HSP10 seem to play an important role in carcinogenesis, supporting tumours in their proliferation, survival, and metastasis. Efforts must be directed toward finding ways to eliminate or block this “mistaken” chaperone. Therefore, the scientific community must develop therapeutic strategies that consider HSP60 and HSP10 as the possible target of an anti-tumoural treatment and not only as diagnostic biomarkers, since they contribute to the evolution of pre-cancerous respiratory pathologies in lung tumours. HSP60 acts at the mitochondrial, cytoplasmic, and extracellular levels in the development of cancer pathologies. The molecular mechanisms in which these chaperones are involved concern cell survival, the restoration of a condition of absence of replicative senescence, the promotion of pro-inflammatory environments, and an increase in the ability to form metastases. In this review, we will also present examples of interactions between HSP60 and HSP10 and different molecules and ways to exploit this knowledge in anticancer therapies for lung tumours. In order to improve not only chances for an earlier diagnosis but also treatments for patients suffering from this type of disease, chaperones must be considered as key agents in carcinogenesis and primary targets in therapeutics.

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HSP60 expression during carcinogenesis: Where is the pilot?

Cited by 4 publications

References 8 publications

Hsp60 expression, new locations, functions, and perspectives for cancer diagnosis and therapy

Hsp60 expression, new locations, functions, and perspectives for cancer diagnosis and therapy

Chaperonotherapy for Alzheimer’s Disease: Focusing on HSP60

Role of HSP60/HSP10 in Lung Cancer: Simple Biomarkers or Leading Actors?

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