Hsp10, Hsp70, and Hsp90 immunohistochemical levels change in ulcerative colitis after therapy

Tomasello, Giovanni; Sciumè, C; Rappa, Francesca; Rodolico, Vito; Zerilli, M; Martorana, Annamaria; Cicero, Giuseppe; Luca, Rossella De; Damiani, Provvidenza; Accardo, Fm; Romeo, Marcello; Farina, Felicia; Bonaventura, Giuseppe; Modica, Giuseppe; Zummo, Giovanni; Macario, Everly Conway de; Macario, Alberto J. L.; Cappello, Francesco

doi:10.4081/ejh.2011.e38

Cited by 50 publications

(40 citation statements)

References 46 publications

(55 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…99 However, one study reported tissue iHSP70 protein concentrations to be higher at the time of disease diagnosis and to decrease after treatment. 100 Animal models of gut inflammation. Chemically induced colitis (e.g., that induced by dextran sulfate sodium) is often used as a model for inflammatory bowel disease.…”

Section: Inflammatory Bowel Disease and Celiac Diseasementioning

confidence: 99%

Gut epithelial inducible heat-shock proteins and their modulation by diet and the microbiota

Arnal

Lallès

2016

Nutr Rev

View full text Add to dashboard Cite

Section: Inflammatory Bowel Disease and Celiac Diseasementioning

confidence: 99%

Gut epithelial inducible heat-shock proteins and their modulation by diet and the microbiota

Arnal

Lallès

2016

Nutr Rev

View full text Add to dashboard Cite

“…In addition, infected macrophages from lesions accumulate HIF-1a and HIF-2a [7]. Here, we evaluate the kinetics of some important inflammatory molecules which are detected immunohistochemically in the cellular infiltrate of various inflammatory diseases, in self-controlled lesions in C57BL/6 mice and severe lesions in Balb/c mice infected with L. amazonensis, including: p38 mitogen-activated protein kinase (p38 MAPK) and cyclooxygenase-2 (COX-2) in arthritis [15,22], migration inhibitory factor (MIF) in arthrosclerosis [34], macrophage inflammatory protein 2 (MIP-2) in encephalomyelitis [37], and heat shock protein 70 kDa (HSP70) in colitis [62]. In addition, VEGF, HIF-1a and HIF-2a, HO-1 [25], and galectin-3 (Gal-3) expression [65] were also investigated in mouse models of cutaneous leishmaniosis.…”

Section: Introductionmentioning

confidence: 99%

Immunohistochemical evidence of stress and inflammatory markers in mouse models of cutaneous leishmaniosis

Araújo

Giorgio

2015

Arch Dermatol Res

View full text Add to dashboard Cite

Leishmanioses are chronic parasitic diseases and host responses are associated with pro- or anti-inflammatory cytokines involved, respectively, in the control or exacerbation of infection. The relevance of other inflammatory mediators and stress markers has not been widely studied and there is a need to search for biomarkers to leishmaniasis. In this work, the stress and inflammatory molecules p38 mitogen-activated protein kinase, cyclooxygenase-2, migration inhibitory factor, macrophage inflammatory protein 2, heat shock protein 70 kDa, vascular endothelial factor (VEGF), hypoxia-inducible factors (HIF-1α and HIF-2α), heme oxygenase and galectin-3 expression were assessed immunohistochemically in self-controlled lesions in C57BL/6 mice and severe lesions in Balb/c mice infected with Leishmania amazonensis. The results indicated that the majority of molecules were expressed in the cutaneous lesions of both C57BL/6 and Balb/c mice during various phases of infection, suggesting no obvious correlation between the stress and inflammatory molecule expression and the control/exacerbation of leishmanial lesions. However, the cytokine VEGF was only detected in C57BL/6 footpad lesions and small lesions in Balb/c mice treated with antimonial pentavalent. These findings suggest that VEGF expression could be a predictive factor for murine leishmanial control, a hypothesis that should be tested in human leishmaniosis.

show abstract

“…In a population of patients with ulcerative colitis, HSP70 expression in the mucosa was markedly higher prior to six months of therapy with 5-ASA preparations and probiotics. This observation suggest that following remission, HSP levels in patients with inflammatory bowel diseases do not differ from those in the healthy population [22].…”

Section: Hsp70 In the Colorectal Mucosa Of Patients With Inflammatorymentioning

confidence: 72%

“…1). In contrast, in the lamina propria the expression of HSP proteins is much lower and seems to be stable, independently of the presence of inflammatory lesions [22].…”

Section: Hsp70 In the Colorectal Mucosa Of Patients With Inflammatorymentioning

confidence: 98%

The Role of HSP70 Heat Shock Proteins in the Pathogenesis and Treatment of Inflammatory Bowel Diseases

Samborski¹,

Grzymisławski²

2015

Adv Clin Exp Med

View full text Add to dashboard Cite

Heat shock proteins (HSPs) represent an important element in the body's defense against various damaging factors. The probably also play an important role in the pathogenesis and treatment of several diseases, including autoimmune pathology and neoplasms. Recently, several investigators have focused their attention on the involvement of the HSP70 protein family in the morbid process of inflammatory bowel diseases (IBD). The HSP70 family of is represented by two distinct forms of protein, the HSP72 protein (also known as the HSP70.1 protein), the expression of which is clearly increased in conditions of stress; and the HSP73 (or HSC73) protein, which manifests stable expression. HSP70 proteins are present in the colorectal epithelium. In patients with inflammatory bowel diseases, their expression in significantly increased during the active stage of the disease. In experimental studies, overexpression of HSP70 was found to prevent the development of inflammatory process in the large intestinal mucosa provoked by various damaging factors. In physiological conditions, various mechanisms are considered to be responsible for an increased expression of HSP70. One of them involves lymphocyte activity and the production of cytokines (mainly IL-2). Another suggested mechanism involves the presence of bacteria in the large intestine, including both physiological flora (Lactobacillus GG, Bacteroides fragilis) and pathogenic bacteria (Salmonella, Escherichia coli). HSP70 expression is probably also increased by physical activity. There is also a potential for pharmacological stimulation of HSP70 expression, linked (for example) to geranylgeranylacetone, polaprezinc and mesalazine. Thus, augmentation of HSP70 expression may become a new element in IBD therapy (Adv Clin Exp Med 2015, 24, 3, 525-530).

show abstract

Hsp10, Hsp70, and Hsp90 immunohistochemical levels change in ulcerative colitis after therapy

Cited by 50 publications

References 46 publications

Gut epithelial inducible heat-shock proteins and their modulation by diet and the microbiota

Gut epithelial inducible heat-shock proteins and their modulation by diet and the microbiota

Immunohistochemical evidence of stress and inflammatory markers in mouse models of cutaneous leishmaniosis

The Role of HSP70 Heat Shock Proteins in the Pathogenesis and Treatment of Inflammatory Bowel Diseases

Contact Info

Product

Resources

About