Hsp 90α and Hsp 90β Genes Are Present in the Zebrafish and Are Differentially Regulated in Developing Embryos

Molecular phylogenies and evolutionary behavior of AhR (aryl hydrocarbon receptor) pathway genes in aquatic animals: Implications for the toxicology mechanism of some persistent organic pollutants (POPs)

“…We can find that the most if not all vertebrates should have both paralogues, and this maybe arouse by a gene duplication event that took place very early in the evolution of eukaryotic cells. Krone and Sass (1994) confirmed it by zebrafish experiment. Despite the marked similarities between the two genes at molecular level, Hsp90a and Hsp90b exhibit different patterns of expression during embryonic development and cell differentiation, and also in response to environmental, physical and chemical stresses.…”

Toxicology mechanism of the persistent organic pollutants (POPs) in fish through AhR pathway

“…Despite marked similarities between the two genes at a molecular level, Hsp90α and Hsp90β exhibit different patterns of expression during embryonic development and cell differentiation, and also in response to environmental stress (Csermely et al 1998). As far as the zebrafish is concerned Hsp90α gene is strongly expressed following heat shock, whereas the Hsp90β is only weakly up-regulated under similar stress conditions (Krone and Sass 1994). These results reveal both functional similarities and key functional differences in the individual members of this protein family (Taherian et al 2008).…”

“…The synthesis of Hsp90 is triggered by stressful cellular conditions such as high temperature, anoxia, radiation, cancer, and environmental pollutant (Feder and Hofmann 1999). During heat shock, both Hsp90α and Hsp90β genes are upregulated in both mouse and human cells; in contrast, Hsp90β gene in zebrafish is weakly responsive or unresponsive to elevated temperature, whereas the Hsp90α gene is strongly upregulated (Krone and Sass 1994). Recently, Padmini and Usha Rani (2009) confirmed that environmental pollutant stress also can induce the Hsp90α expression in grey mullets.…”

“…Hsp90 protein is well conserved within aquatic animals, there are two types of Hsp90 genes within the fishes, namely Hsp90a and HSP90b, which encode two similar cytosolic isoforms (Moore et al 1987;Krone and Sass 1994). Despite marked similarities between the two genes at a molecular level, Hsp90α and Hsp90β exhibit different patterns of expression during embryonic development and cell differentiation, and also in response to environmental stress (Csermely et al 1998).…”

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“…Mammalian genomes encode two closely related Hsp90 genes, namely as alpha and beta. Both have been sequenced in zebrafish, both have been shown to be differentially regulated in developing embryos (Krone and Sass, 1994). A complete sequence of an hsp90a has also been obtained from the chinook salmon (Oncorhynchus tshawytscha) (Palmisano et al, 2000;Eder et al, 2009).…”