Hsp-72, a candidate prognostic indicator of heatstroke

Dehbi, Mohammed; Baturcam, Engin; Eldali, Abdelmoneim; Ahmed, Mohiuddin; Kwaasi, A. A. A.; Chishti, M. Azhar; Bouchama, Abderrezak

doi:10.1007/s12192-010-0172-3

Cited by 46 publications

(49 citation statements)

References 42 publications

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“…Given that ⌬T re is ruled out, we speculate that hormonal or metabolic reflex changes upon acclimation and training may play a role (15,29,35). The increase in eHSP in acclimated dogs is in agreement with previous findings (10,33,35). Recently, it was reported that initial training induced an increase in eHSP levels that diminished the need for further induction of the protein during exercise (33).…”

Section: Discussionsupporting

confidence: 90%

Two years of combined high-intensity physical training and heat acclimatization affect lymphocyte and serum HSP70 in purebred military working dogs

Bruchim

Aroch

Eliav

et al. 2014

Journal of Applied Physiology

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Military working dogs in hot countries undergo exercise training at high ambient temperatures for at least 9 mo annually. Physiological adaptations to these harsh conditions have been extensively studied; however, studies focusing on the underlying molecular adaptations are limited. In the current study, military working dogs were chosen as a model to examine the effects of superimposing endurance exercise on seasonal acclimatization to environmental heat stress. The lymphocyte HSP70 profile and extracellular HSP70 were studied in tandem with physiological performance in the dogs from their recruitment for the following 2 yr. Aerobic power and heat shock proteins were measured at the end of each summer, with physical performance tests (PPTs) in an acclimatized room (22°C). The study shows that together with a profound enhancement of aerobic power and physical performance, hsp72 mRNA induction immediately post-PPT and 45 min later, progressively increased throughout the study period (relative change in median lymphocyte hsp72 mRNA first PPT, 4.22 and 12.82; second PPT, 17.19 and 109.05, respectively), whereas induction of HSP72 protein was stable. These responses suggest that cellular/molecular adaptive tools for maintaining HSP72 homeostasis exist. There was also a significant rise in basal and peak median optical density extracellular HSP at the end of each exercise test (first PPT, 0.13 and 0.15; second PPT, 1.04 and 1.52, respectively). The relationship between these enhancements and improved aerobic power capacity is not yet fully understood.

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Section: Discussionsupporting

confidence: 90%

Two years of combined high-intensity physical training and heat acclimatization affect lymphocyte and serum HSP70 in purebred military working dogs

Bruchim

Aroch

Eliav

et al. 2014

Journal of Applied Physiology

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“…The high extracellular concentration of HSPA1A was even greater in patients with MODS. Although the present study did not perform followup of survival after hospital discharge and all patients except one survived during admission, the greater elevation of extracellular HSPA1A in patients with MODS corroborates the proinflammatory role of this protein in situations of severe trauma reported by other authors, who also correlated it with survival and morbidity [22] and even proposed it as a prime example of DAMPS [23]. Therefore, it can be suspected that the release of HSPA1A into serum could provide the organism with a way to monitor the extent of damage to organs and tissue after trauma and that because its plasma levels are associated with MODS raises the possibility that HSPA1A could serve as a useful prognostic trauma biomarker early after severe injury.…”

Section: Discussionsupporting

confidence: 89%

Early inflammatory response in polytraumatized patients: Cytokines and heat shock proteins. A pilot study

Guisasola

Ortíz

Chana

et al. 2015

Orthopaedics & Traumatology: Surgery & Research

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“…All these findings reveal a complex network of interactions that orchestrates the inflammatory response in HS. Animal and human data demonstrate that plasma concentration of such cytokines increase in a time- and core temperature-dependent manner [35,37,38], and they could be considered as possible markers of HS prognosis [39,40]. …”

Section: Discussionmentioning

confidence: 99%

“…In humans, exertional HS has been shown to be a potent inducer of HSP-72 expression [41]. In baboons subjected to HS [40], the markers of cell injury and organ dysfunction significantly correlated with HSP-72 levels. Circulating HSP-72 may indicate the extent of tissue damage.…”

Section: Discussionmentioning

confidence: 99%

Non-Exertional Heatstroke: A Case Report and Review of the Literature

et al. 2017

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Patient: Female, 41Final Diagnosis: HeatstrokeSymptoms: ComaMedication: —Clinical Procedure: Intensive Care Unit-Internal MedicineSpecialty: Critical Care MedicineObjective:Rare co-existance of disease or pathologyBackground:Heatstroke (HS) is a life-threatening condition characterized by an elevation of the core body temperature above 40°C, central nervous system dysfunction, and possible multi-organ failure. HS can trigger systemic inflammation, disseminated intravascular coagulation (DIC), rhabdomyolysis, cerebral edema and seizures, pulmonary edema, heart dysfunctions, and renal and hepatic failure.Case Report:We report the case of a 41-year-old Romanian woman with a history of alcoholism who developed HS after arriving by bus in Verona, Italy in June 2016. The patient developed consecutive multi-organ dysfunction, including liver and renal failure, rhabdomyolysis, DIC, and arrhythmia. The patient was successfully treated with conservative measures. After 17 days, she recovered completely.Conclusions:The exact mechanism of HS-related multiple organ dysfunction is not completely understood and its pathogenesis is complex. It involves inflammation, oxidative stress, endoplasmic reticulum (ER) stress, and mitochondrial dysfunction. Development of a model in which chronic alcohol abuse alters oxidative, inflammatory, and ER stress response could also be a conceivable solution to the positive prognosis of severe HS patients, in which liver failure has a prominent role.

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Hsp-72, a candidate prognostic indicator of heatstroke

Cited by 46 publications

References 42 publications

Two years of combined high-intensity physical training and heat acclimatization affect lymphocyte and serum HSP70 in purebred military working dogs

Two years of combined high-intensity physical training and heat acclimatization affect lymphocyte and serum HSP70 in purebred military working dogs

Early inflammatory response in polytraumatized patients: Cytokines and heat shock proteins. A pilot study

Non-Exertional Heatstroke: A Case Report and Review of the Literature

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