Abstract:Stress responses play a pivotal role in normal physiology, a feature exploited by cancer cells to facilitate growth, counteract genomic instability, and resist therapeutic stress. Heat shock factor-1 (HSF1), a major stress-response transcription factor, exhibits a significant upregulation in activity in cancer. While HSF1's role in transcription is relatively well-known, the mechanisms governing its activation, particularly in tumors, remain unclear. To determine whether HSF1 is the primary sensor of proteotox… Show more
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