Hypersonic Cruise Vehicle (HCV) is defined as one kind of vehicle which mission is cruising in atmosphere, and generally with cruising velocity between Mach number 6 and 12. HCV generally utilizes scramjet as high-speed propulsion system, which is highly integrated with airframe. Due to the intense interactions between engine and airframe, the preliminary design of HCV is needed to be considered as a multidisciplinary design and optimization process in which aerodynamics, aeroheating, propulsion, weight and sizing, trajectory and control, performance and cost must be accounted simultaneously. This paper presents the results of an effort to multidisciplinary preliminary design and optimization of HCV with the highly scramjet engine/airframe integration using parameter methods. Disciplinary analysis models including propulsion performance, aerodynamic force accounting, aeroheating performance, weights and sizing, and life cycle cost are set up before implementing optimization process. Response surface models for aerodynamic performance and scramjet performance are constructed with variable-complexity modeling (VCM) techniques. The goal is to optimize a HCV to minimize gross take-off weight (GTOW) or life cycle cost (LCC) under a reference mission. Taguchi design method, uniform design method and D-optimal design method are used to evaluate the effects of changing 10 design parameters of scramjet/airframe in an integration methodology. The optimal result suggests a vehicle with GTOW 11.16% lighter and LCC 4.02% cheaper than the initial design with baseline configuration. Nomenclature exp − aft Ang = afterbody lower surface expansion angle exp − com Ang = combustor divergence duct expansion angle 1 inlet Ang = the first compression angle 2 inlet Ang = the second compression angle = the third compression angle D C = drag coefficient L C = lift coefficient max T C = maximum thrust coefficient PB xmc C = flat plate friction coefficient in low velocity flow xlw C = wing drag coefficient due to lift xw C = wing drag coefficient w x C 0 = wing zero-lift drag coefficient α yw C = wing lift curve slope D = drag com F = thrust due to combustor w g = ratio of wall enthalpy to total enthalpy h = altitude cruise H = cruise altitude w h = wall enthalpy s h = total enthalpy sp I = specific impulse L = lift m = mass M = constant Ma = Mach Number design Ma = inlet design Mach number trans Ma = transition Mach number f m & = fuel mass flow rate N = constant q = dynamic pressure cyl q & = heating rate of infinite swept cylinder fp q & = heating rate of inclined flat plate le q & = heating rate of leading edge axis s q , & = heating rate of stagnation point of an axisymmetric body base R = ratio of base height to fuselage height con com R − = ratio of combustor constant area duct length to combustor total length engine R = ratio of combustor length to vehicle length forebody R = ratio of forebody length to vehicle length N R = radius of nose s = throttle setting ref S = reference area t = time T = thrust V = velocity X = matrix plume X...