Hsa_circ_0136666 activates Treg-mediated immune escape of colorectal cancer via miR-497/PD-L1 pathway

Xu, Yanjie; Zhao, Jiemin; Cao, Gaoping; Ni, Xuefeng; Wang, Wei; Hu, Wenwei; Wu, Changping

doi:10.1016/j.cellsig.2021.110095

Cited by 36 publications

(18 citation statements)

References 32 publications

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“…For evaluation of the association between immune checkpoints and hsa_circ_0000190, relevant ligands were selected, such as CD80/CD86, which interacted with CTLA-4 and CD28 for T-cell inhibition or activation, respectively. The other immune checkpoints included TIM-3, BTLA, TIGIT, LAG-3, and PD-1, and the related binding partners were galectin-9, HVEM, PVR (CD155), HLA-DR, and PD-L1, respectively [ 13 , 14 , 15 , 16 , 17 ].…”

Section: Methodsmentioning

confidence: 99%

“…Multiple studies have reported the role of circRNAs in regulating the expression of PD-L1 through circRNA–miRNA–mRNA axis. A number of circRNAs, such as circBART2.2, hsa_circ_0136666, circ-keratin 6c, CDR1-AS, circ-VIM, hsa_circ_0003288, CircCHST15, circ-CPA4, hsa-circRNA-002178, and Circ_0000284 were shown to affect PD-L1 expression, leading to tumor immune escape in various types of cancers, including nasopharyngeal carcinoma, colorectal cancer, esophageal cancer, hepatocellular carcinomas (HCC), and lung cancer [ 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 ]. Our previous study discovered the correlation between hsa_circ_0000190 plasma level and PD-L1 level in patients with lung cancer.…”

Section: Introductionmentioning

confidence: 99%

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Circular RNA hsa_circ_0000190 Facilitates the Tumorigenesis and Immune Evasion by Upregulating the Expression of Soluble PD-L1 in Non-Small-Cell Lung Cancer

Luo

Yang

Chien

et al. 2021

IJMS

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Lung cancer is the leading cause of death from cancer in Taiwan and throughout the world. Immunotherapy has revealed promising and significant efficacy in NSCLC, through immune checkpoint inhibition by blocking programmed cell death protein (PD)-1/PD-1 ligand (PD-L1) signaling pathway to restore patients’ T-cell immunity. One novel type of long, non-coding RNAs, circular RNAs (circRNAs), are endogenous, stable, and widely expressed in tissues, saliva, blood, urine, and exosomes. Our previous results revealed that the plasma level of hsa_circ_0000190 can be monitored by liquid-biopsy-based droplet digital PCR and may serve as a valuable blood-based biomarker to monitor the disease progression and the efficacy of immunotherapy. In this study, hsa_circ_0000190 was shown to increase the PD-L1 mRNA-mediated soluble PD-L1 (sPD-L1) expression, consequently interfering with the efficacy of anti-PD-L1 antibody and T-cell activation, which may result in immunotherapy resistance and poor outcome. Our results unraveled that hsa_circ_0000190 facilitated the tumorigenesis and immune evasion of NSCLC by upregulating sPD-L1 expression, potentially developing a different aspect in elucidating the molecular immunopathogenesis of NSCLC. Hsa_circ_0000190 upregulation can be an effective indicator for the progression of NSCLC, and hsa_circ_0000190 downregulation may possess a potential therapeutic value for the treatment of NSCLC in combination with immunotherapy.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Circular RNA hsa_circ_0000190 Facilitates the Tumorigenesis and Immune Evasion by Upregulating the Expression of Soluble PD-L1 in Non-Small-Cell Lung Cancer

Luo

Yang

Chien

et al. 2021

IJMS

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“…Overexpression of circ0005963 has been shown to enhance glycolysis and drug resistance to increase the size of drug-resistant tumors in vivo ( 119 ). Circ0136666 was reported to function as a tumor promotor by mediating Treg-mediated immune escape ( 126 ).…”

Section: Colorectal Cancermentioning

confidence: 99%

Mechanism underlying circRNA dysregulation in the TME of digestive system cancer

Zhang

et al. 2022

Front. Immunol.

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Circular RNAs (circRNAs) are a new series of noncoding RNAs (ncRNAs) that have been reported to be expressed in eukaryotic cells and have a variety of biological functions in the regulation of cancer pathogenesis and progression. The TME, as a microscopic ecological environment, consists of a variety of cells, including tumor cells, immune cells and other normal cells, ECM and a large number of signaling molecules. The crosstalk between circRNAs and the TME plays a complicated role in affecting the malignant behaviors of digestive system cancers. Herein, we summarize the mechanisms underlying aberrant circRNA expression in the TME of the digestive system cancers, including immune surveillance, angiogenesis, EMT, and ECM remodelling. The regulation of the TME by circRNA is expected to be a new therapeutic method.

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“…Similar studies have also reported that cirCCDR1-AS can significantly increase PD-L1 expression on the surface of colon cancer cells through CMTM4 and CMTM6, leading to a poor prognosis ( 92 ). Hsa_circ_0136666 promotes PD-L1 expression in CRC by inhibiting miR-497, which stimulates the production of Treg cells and causes immune escape ( 93 ). Circ-KRT6C can improve the presentation of PD-L1 by acting as a miR-485-3p sponge, thus promoting the malignant progression and immune escape of CRC cells ( 94 ).…”

Section: Role Of Circrna In Digestive Cancer Immunitymentioning

confidence: 99%

Circular RNAs Involve in Immunity of Digestive Cancers From Bench to Bedside: A Review

Chen

Tang

et al. 2022

Front. Immunol.

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The immune system plays a complex role in tumor formation and development. On the one hand, immune surveillance can inhibit the growth of tumors; on the other hand, immune evasion of tumors can create conditions conducive for tumor development and growth. CircRNAs are endogenous non-coding RNAs with a covalently closed loop structure that are abundantly expressed in eukaryotic organisms. They are characterized by stable structure, rich diversity, and high evolutionary conservation. In particular, circRNAs play a vital role in the occurrence, development, and treatment of tumors through their unique functions. Recently, the incidence and mortality of digestive cancers, especially those of gastric cancer, colorectal cancer, and liver cancer, have remained high. However, the functions of circRNAs in digestive cancers immunity are less known. The relationship between circRNAs and digestive tumor immunity is systematically discussed in our paper for the first time. CircRNA can influence the immune microenvironment of gastrointestinal tumors to promote their occurrence and development by acting as a miRNA molecular sponge, interacting with proteins, and regulating selective splicing. The circRNA vaccine even provides a new idea for tumor immunotherapy. Future studies should be focused on the location, transportation, and degradation mechanisms of circRNA in living cells and the relationship between circRNA and tumor immunity. This paper provides a new idea for the diagnosis and treatment of gastrointestinal tumors.

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Hsa_circ_0136666 activates Treg-mediated immune escape of colorectal cancer via miR-497/PD-L1 pathway

Cited by 36 publications

References 32 publications

Circular RNA hsa_circ_0000190 Facilitates the Tumorigenesis and Immune Evasion by Upregulating the Expression of Soluble PD-L1 in Non-Small-Cell Lung Cancer

Circular RNA hsa_circ_0000190 Facilitates the Tumorigenesis and Immune Evasion by Upregulating the Expression of Soluble PD-L1 in Non-Small-Cell Lung Cancer

Mechanism underlying circRNA dysregulation in the TME of digestive system cancer

Circular RNAs Involve in Immunity of Digestive Cancers From Bench to Bedside: A Review

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