Hsa_circ_0051079 functions as an oncogene by regulating miR-26a-5p/TGF-β1 in osteosarcoma

Zhang, Zuojun; Zhao, Ming; Wang, Guojie

doi:10.1186/s13578-019-0355-2

Cited by 21 publications

(15 citation statements)

References 29 publications

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“… 10 , 11 , 12 , 13 Additionally, growing evidence indicates that circRNAs can influence carcinogenesis in osteosarcoma. 14 , 15 , 16 , 17 , 18 Previous studies reported that circRNAs acted as competing endogenous RNAs (ceRNAs) by turning into “microRNA (miRNA) sponges,” i.e., miRNA inhibitors. 19 , 20 …”

Section: Introductionmentioning

confidence: 99%

circCAMSAP1 promotes osteosarcoma progression and metastasis by sponging miR-145-5p and regulating FLI1 expression

Chen

Zhang

et al. 2021

Molecular Therapy - Nucleic Acids

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Osteosarcoma is the most common primary malignant bone tumor in adolescents. While chemotherapy combined with surgery can improve the prognosis of some patients, chemo-resistance is still a huge obstacle in osteosarcoma treatment. Accumulating evidence demonstrates that circular RNAs (circRNAs) are involved in cancer progression and metastasis, but their specific role in osteosarcoma remains mostly undescribed. In this study, we performed circRNA deep sequencing and identified 88 distinct circRNAs from a human osteosarcoma cell lines group (143B, HOS, SJSA, and U2OS) and the human osteoblast hFOB 1.19 (control). We found that circCAMSAP1, also named hsa_circ_0004338, is significantly upregulated in human osteosarcoma tissues and cell lines, and it is positively correlated with osteosarcoma development. Silencing of circCAMSAP1 effectively suppresses osteosarcoma cell growth, apoptosis, migration, and invasion. Furthermore, we validated that circCAMSAP1 functions in osteosarcoma tumorigenesis through a circCAMSAP1/miR-145-5p/friend leukemia virus integration 1 (FLI1) pathway. FLI1 promotes osteosarcoma tumorigenesis and miR-145-5p suppresses FLI translation. circCAMSAP1 directly sequesters miR-145-5p in the cytoplasm and inhibits its activity to suppress osteosarcoma tumorigenesis. Moreover, the regulatory role of circCAMSAP1 upregulation was examined and validated in rats. In summary, our findings provide evidence that circCAMSAP1 act as a “microRNA sponge” and suggest a new therapeutic target of human osteosarcoma.

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Section: Introductionmentioning

confidence: 99%

circCAMSAP1 promotes osteosarcoma progression and metastasis by sponging miR-145-5p and regulating FLI1 expression

Chen

Zhang

et al. 2021

Molecular Therapy - Nucleic Acids

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“…Circ-phosphoglycerate mutase 1 (circ-PGAM1) was demonstrated to accelerate cell proliferation in ovarian cancer through binding to miR-542-3p ( Zhang et al, 2020 ). Also disclosed that circ_0051079 promoted osteosarcoma development by modulating miR-26a-5p ( Zhang et al, 2019 ). Exciting evidence showed circ_0009112 was one of the top 10 upregulated circRNAs in chemo-resistant osteosarcoma cell lines ( Zhu et al, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

Schisandrin B Inhibits Cell Viability and Migration, and Induces Cell Apoptosis by circ_0009112/miR-708-5p Axis Through PI3K/AKT Pathway in Osteosarcoma

Wang

Xing

et al. 2020

Front. Genet.

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Osteosarcoma is a primary tumor of bone and its incidence is increasing. Schisandrin B (Sch B), a generally used lignan in Chinese medicine, has been found to repress cancer progression. This study aims to reveal the effects and regulatory mechanism of Sch B in the viability, apoptosis and migration of osteosarcoma cells. In this study, we found circ_0009112 expression was higher and miR-708-5p expression was lower in SaOS2 and U2OS cells than in hFOB1.19 cells. Circ_0009112 expression was downregulated, but miR-708-5p was upregulated by Sch B treatment in a dose-dependent manner in SaOS2 and U2OS cells. Sch B exposure inhibited osteosarcoma development in vitro and in vivo; however, these effects were restored by circ_0009112. Furthermore, circ_0009112 acted as a sponge of miR-708-5p. Circ_0009112 regulated PI3K/AKT pathway after Sch B treatment by associating with miR-708-5p. Sch B exposure inhibited cell viability and migration, whereas promoted cell apoptosis by regulating circ_0009112/miR-708-5p axis through PI3K/AKT pathway in osteosarcoma cells. This study provided a theoretical basis for further studying osteosarcoma therapy with Sch B.

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“…TGF-β is a crucial member of the TGF-β superfamily that is involved in EMT to regulate cell growth and differentiation ( 85 ). TGF-β1 was validated as a putative target of miR-26a-5p, which is bioinformatically analyzed to be sponged by circ_0051079 ( 60 ). The Wnt/β-catenin signaling pathway is one of the predisposing factors of EMT, which directs cancer cell migration, adhesion, invasion, and metastasis and is closely bound up with degradation of the extracellular matrix and tumor angiogenesis.…”

Section: Circrna and Osteosarcoma Metastasismentioning

confidence: 99%

“…High circ-NT5C2 expression was thought to be an independent prognostic parameter to predict poor prognosis by sponging miR-448 ( 52 , 53 ). Additional upregulated circRNAs included circUBAP2 ( 65 ), hsa_circ_0000885 ( 45 ), hsa_circ_0081001 ( 54 ), hsa_circ_0004674 ( 28 ), hsa_circ_0000006 ( 31 ), hsa_circ_0051079 ( 60 ), hsa_circ_0007534 ( 57 ), and PVT1 ( 61 ).…”

Section: Circrna and Osteosarcoma Prognosismentioning

confidence: 99%

Emerging Roles and Potential Biological Value of CircRNA in Osteosarcoma

Liu

Yang

et al. 2020

Front. Oncol.

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Circular RNAs (circRNAs) are endogenous noncoding RNAs that are widely found in eukaryotic cells. They have been found to play a vital biological role in the development of human diseases. At present, circRNAs have been involved in the pathogenesis, diagnosis, and targeted treatment of multiple tumors. This article reviews the research progress of circRNAs in osteosarcoma (OSA) in recent years. The potential connection between circRNAs and OSA cell proliferation, apoptosis, metastasis, and chemotherapy sensitivity or resistance, as well as clinical values, is described in this review. Their categories and functions are generally summarized to facilitate a better understanding of OSA pathogenesis, and findings suggest novel circRNA-based methods may be used to investigate OSA and provide an outlook for viable biomarkers and therapeutic targets.

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Hsa_circ_0051079 functions as an oncogene by regulating miR-26a-5p/TGF-β1 in osteosarcoma

Cited by 21 publications

References 29 publications

circCAMSAP1 promotes osteosarcoma progression and metastasis by sponging miR-145-5p and regulating FLI1 expression

circCAMSAP1 promotes osteosarcoma progression and metastasis by sponging miR-145-5p and regulating FLI1 expression

Schisandrin B Inhibits Cell Viability and Migration, and Induces Cell Apoptosis by circ_0009112/miR-708-5p Axis Through PI3K/AKT Pathway in Osteosarcoma

Emerging Roles and Potential Biological Value of CircRNA in Osteosarcoma

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