Hsa_circ_0044235 and hsa_circ_0001947 as novel biomarkers in plasma of patients with new-onset systemic lupus erythematosus

Luo, Qing; Ye, Yutao; Zhang, Lu; Gao, Yujie; Rao, Jiayue; Guo, Yang; Huang, Qingshui; Huang, Zikun; Li, Junming

doi:10.1080/1547691x.2023.2196453

Cited by 2 publications

(3 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Extensive evidence suggests that circRNAs may play significant roles in neurological disorders, atherosclerotic vascular disease, cancer, and autoimmune diseases. This supports the notion that circRNAs have the potential to serve as novel diagnostic and prognostic biomarkers and represent promising therapeutic targets for various diseases [ 12 , 13 ]. Interestingly, circ-tubulin delta 1 (circ-TubD1) has been demonstrated to act as miR-146a-5p sponge, affecting pro-inflammatory cytokine production through regulating the expression of TRAF6 in hepatic cell line [ 7 ].…”

Section: Introductionsupporting

confidence: 80%

“…These studies supported the potential use of circ-0044235 as a diagnostic biomarker for SLE, but the results were inconsistent in these studies, where a previous study of Luo et al [ 12 ] demonstrated a decrease in the level of circ-0044235 in peripheral blood leukocytes of SLE patients; however, a significant increase in its level was detected in new-onset SLE. On the other hand, Luo et al [ 13 ] reported a decrease in the level of circ-0044235 in new-onset SLE. In addition, circ-0140271, a circRNA generated from the mediator complex subunit 14 (MED14) gene located on the X-chromosome, was suggested as a potential diagnostic biomarker for the chronic autoimmune disease; rheumatoid arthritis (RA), as it may act as miRNA sponge to regulate fatty acid metabolism pathways in RA [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Functional analysis of a panel of molecular markers for diagnosis of systemic lupus erythematosus in rats

Azzam,

Fahim,

ElMonier

et al. 2024

Bioscience Reports

View full text Add to dashboard Cite

The aim of this study was to determine the role of a panel of noncoding-RNAs specifically circRNAs (circ-TubD1, circ-CDC27, and circ-Med14), along with miRNA (rno-miR-146a-5p) and mRNA (TRAF6), as novel minimally invasive diagnostic biomarkers for experimentally induced SLE. Additionally, the study involved an insilico bioinformatics analysis to explore potential pathways involved in the pathogenesis of SLE, aiming to enhance our understanding of the disease, enable early diagnosis, and facilitate improved treatment strategies. SLE was induced in rats using single IP injection of incomplete Freund’s adjuvant (IFA). The Induction was confirmed by assessing the ANA and anti-ds DNA levels using ELSA technique. qPCR analysis was conducted to assess the expression of selected RNAs in sera collected from a group of 10 rats with induced SLE and a control group of 10 rats. In addition, bioinformatics and functional analysis were used to construct a circRNA-miRNA-mRNA network and to determine the potential function of these differentially expressed circRNAs. SLE rats demonstrated significantly higher expression levels of circ-CDC27, circ-Med14 and rno-miR-146a-5p as well as TRAF6, with lower expression level of circ-TubD1 in sera of SLE rats relative to controls. ROC curve analysis indicated that all the selected non-coding RNAs could serve as potential early diagnostic markers for SLE. In addition, the expression level of circ-TubD1 was negatively correlated with rno-miR-146a-5p, however, rno-miR-146a-5p was positively correlated with TRAF6. Bioinformatic analysis revealed the incorporation of the circRNAs targeted genes in various immune system and neurodegeneration pathways.

show abstract

Section: Introductionsupporting

confidence: 80%

Section: Introductionmentioning

confidence: 99%

Functional analysis of a panel of molecular markers for diagnosis of systemic lupus erythematosus in rats

Azzam,

Fahim,

ElMonier

et al. 2024

Bioscience Reports

View full text Add to dashboard Cite

show abstract

“…Furthermore, studies have indicated that cfRNA molecules are associated with T-cell tolerance by affecting T-cell development and function, regulating the immune system's tolerance to autoantigens, and preventing the occurrence of autoimmune diseases [61]. Abnormal expressions of cfRNA are linked to the occurrence and development of autoimmune diseases, such as rheumatoid arthritis [62] and systemic lupus erythematosus [63].…”

Section: Biological Functions Of Cfrnamentioning

confidence: 99%

A Comprehensive Review on Circulating cfRNA in Plasma: Implications for Disease Diagnosis and Beyond

Zhong,

Bai,

Hong

et al. 2024

Diagnostics

View full text Add to dashboard Cite

Circulating cfRNA in plasma has emerged as a fascinating area of research with potential applications in disease diagnosis, monitoring, and personalized medicine. Circulating RNA sequencing technology allows for the non-invasive collection of important information about the expression of target genes, eliminating the need for biopsies. This comprehensive review aims to provide a detailed overview of the current knowledge and advancements in the study of plasma cfRNA, focusing on its diverse landscape and biological functions, detection methods, its diagnostic and prognostic potential in various diseases, challenges, and future perspectives.

show abstract

Hsa_circ_0044235 and hsa_circ_0001947 as novel biomarkers in plasma of patients with new-onset systemic lupus erythematosus

Cited by 2 publications

References 41 publications

Functional analysis of a panel of molecular markers for diagnosis of systemic lupus erythematosus in rats

Functional analysis of a panel of molecular markers for diagnosis of systemic lupus erythematosus in rats

A Comprehensive Review on Circulating cfRNA in Plasma: Implications for Disease Diagnosis and Beyond

Contact Info

Product

Resources

About