Hsa_circ_0007534/miR-761/ZIC5 regulatory loop modulates the proliferation and migration of glioma cells

Li, Guangfeng; Li, Li; Yao, Zongqin; Zhuang, Sujing

doi:10.1016/j.bbrc.2018.03.219

Cited by 64 publications

(60 citation statements)

References 24 publications

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“…Previous studies showed that miR‐761 is increased in HCC and targets Mitofusin‐2 to regulate tumor growth and metastasis . miR‐761 has also been verified as the sponging miRNA of has_circ_0007534 in glioma . Moreover, elevated miR‐761 expression has been observed in triple‐negative breast cancer, synovial sarcoma and non‐small cell lung cancer .…”

Section: Discussionmentioning

confidence: 97%

“…23 miR-761 has also been verified as the sponging miRNA of has_circ_0007534 in glioma. 33 Moreover, elevated miR-761 expression has been observed in triple-negative breast cancer, 34 synovial sarcoma 35 and non-small cell lung cancer. 36 We identified that miR-761 was the downstream target of circLARP4, and was associated with circLARP4-mediated cellular senescence in HCC.…”

Section: Discussionmentioning

confidence: 99%

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circLARP4 induces cellular senescence through regulating miR‐761/RUNX3/p53/p21 signaling in hepatocellular carcinoma

Chen

Zuo

et al. 2019

Cancer Science

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Circular RNAs (circRNAs), a novel class of non‐coding RNAs, have emerged as indispensable modulators in human malignancies. Aberrant cellular senescence is a phenotype observed in various cancers. The association of circRNAs with cellular senescence in tumors is yet to determined. Here, we investigated the role of circLARP4 in cellular senescence and cell proliferation in hepatocellular carcinoma (HCC). Downregulated circLARP4 level was observed in HCC tissues and cell lines. Low expression level of circLARP4 independently predicted poor survival outcome. Gain‐of‐function and loss‐of‐function assays demonstrated that circLARP4 suppressed HCC cell proliferation, mediated cell cycle arrest and induced senescence in vitro. Levels of p53 and p21, 2 key regulatory molecules in cellular senescence, were increased in circLARP4‐overexpressed HCC cells and decreased in circLARP4‐silenced HCC cells. In vivo experiments further confirmed the tumor‐suppressing activity of circLARP4. Further mechanistic studies showed that circLARP4 dampened HCC progression by sponging miR‐761, thereby promoting the expression level of RUNX3 and activating the downstream p53/p21 signaling. Our study revealed the role of circLARP4/miR‐761/RUNX3/p53/p21 signaling in HCC progression, providing a potential survival predictor and therapeutic candidate for HCC.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

circLARP4 induces cellular senescence through regulating miR‐761/RUNX3/p53/p21 signaling in hepatocellular carcinoma

Chen

Zuo

et al. 2019

Cancer Science

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“…We indicated that miR-214-3p and miR-7-5p can regulate the VEGF pathway by deregulating NFATC4, PIK3R3, PRKCB, and PIK3CD, and angiogenesis typically occurs in psoriatic lesions [1]. Upregulated miR-761 has been found to be involved in modulating the proliferation and migration of glioma cells and in inducing skin inflammation by the neuroendocrine system and HPA axis [73]. Downregulated miR-665 has been found to be involved in cognitive dysfunction and astrocyte and neuroblastoma cell growth [74][75][76].…”

Section: Journal Of Immunology Researchmentioning

confidence: 93%

Plasma MicroRNA Expression Profiles in Psoriasis

Xiao

Liu

Wang

et al. 2020

Journal of Immunology Research

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Background. Psoriasis is an immune-mediated inflammatory chronic skin disease characterized by chronic inflammation in the dermis, parakeratosis, and excessive epidermal growth. MicroRNAs (miRNAs) are key regulators of immune responses. Although differential expression of miRNAs has been reported in certain inflammatory autoimmune diseases, their role in psoriasis has not been fully illuminated. Our aims were to confirm plasma miRNA expression signatures in psoriasis and to examine their potential influence on psoriasis pathogenesis. Methods. A miRNome PCR array was used to analyse the plasma of psoriasis patients and healthy donors. We performed miRNA pathway enrichment and target gene network analyses on psoriasis plasma samples. Results. We found several specific plasma miRNA signatures relevant to psoriasis. The miRNAs targeted pathways associated with psoriasis, such as the VEGF, MAPK, and WNT signaling pathways. Network analysis revealed pivotal deregulated plasma miRNAs and their relevant target genes and pathways regulating psoriasis pathogenesis. Conclusions. This study analysed the expression of plasma miRNAs and their target pathways, elucidating the pathogenesis of psoriasis; these results may be used to design novel therapeutic strategies and to identify diagnostic biomarkers for psoriasis.

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“…Recently, several circRNAs have been detected in the blood and were used as biomarkers for cancer diagnosis due to their high stability, high abundance, and tissue specificity . Furthermore, an increasing number of studies have shown that circRNAs play important roles in various cancer‐related processes, including proliferation, migration, invasion, and apoptosis . However, the roles of circRNAs in GC are largely unknown.…”

Section: Introductionmentioning

confidence: 99%

“…9,10 Furthermore, an increasing number of studies have shown that cir-cRNAs play important roles in various cancer-related processes, including proliferation, migration, invasion, and apoptosis. 14,15 However, the roles of circRNAs in GC are largely unknown.…”

Section: Introductionmentioning

confidence: 99%

Hsa_circ_0000467 promotes cancer progression and serves as a diagnostic and prognostic biomarker for gastric cancer

Lü

Zhang

Xie

et al. 2018

Clinical Laboratory Analysis

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Background Emerging evidence indicates that dysregulation of circular RNAs (circRNAs) is implicated in the development of malignancies. However, the diagnostic value and functional role of circRNAs in gastric cancer (GC) remain largely elusive. Methods Quantitative reverse transcription‐polymerase chain reaction (qRT‐PCR) was performed to detect the expression of hsa_circ_0000467 in tissues, cell lines, and plasma. A receiver operating characteristic (ROC) curve was constructed to estimate the diagnostic value of hsa_circ_0000467. The association between the expression level of hsa_circ_0000467 and the clinicopathological features was analyzed. Moreover, cell functional assays were performed. Results Hsa_circ_0000467 was significantly upregulated in GC tissue compared to adjacent nontumor tissue (n = 51, P < 0.05). Similar results were detected in the HGC‐27, MGC‐803, AGS, NUGC‐3, GES‐1 cell lines (n = 15, P < 0.001), and in the plasma samples from GC patients (n = 20, P < 0.05). The area under the ROC curve of hsa_circ_0000467 was 0.790, which is superior to commonly used biomarkers including CEA and CA‐724. We found that the expression levels of hsa_circ_0000467 in the same patient were significantly lower after surgery (n = 20, P < 0.05). Moreover, the hsa_circ_0000467 expression level is closely associated with TNM stage. Additionally, Cox multivariate analysis showed that hsa_circ_0000467 is a novel independent prognostic factor. Furthermore, in vitro experiments demonstrated that knockdown of hsa_circ_0000467 markedly inhibited the proliferation, migration, and invasion of GC cells. Moreover, hsa_circ_0000467 silencing increased tumor apoptosis in vitro. Conclusion Hsa_circ_0000467 can act as a novel noninvasive biomarker for the diagnosis and prognosis of GC and may be a potential therapeutic target for GC.

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Hsa_circ_0007534/miR-761/ZIC5 regulatory loop modulates the proliferation and migration of glioma cells

Cited by 64 publications

References 24 publications

circLARP4 induces cellular senescence through regulating miR‐761/RUNX3/p53/p21 signaling in hepatocellular carcinoma

circLARP4 induces cellular senescence through regulating miR‐761/RUNX3/p53/p21 signaling in hepatocellular carcinoma

Plasma MicroRNA Expression Profiles in Psoriasis

Hsa_circ_0000467 promotes cancer progression and serves as a diagnostic and prognostic biomarker for gastric cancer

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