Hsa_circ_0000437 promotes pathogenesis of gastric cancer and lymph node metastasis

Shen, Xianjuan; Kong, Shan; Ma, Shuo; Shen, Lei; Zheng, Ming; Qin, Shiyi; Qi, Ji; Wang, Qiuhong; Cui, Xiaopeng; Ju, Shao-Qing

doi:10.1038/s41388-022-02449-w

Cited by 19 publications

(15 citation statements)

References 44 publications

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“…Here, we found that MAP4K4 could also mediate the SOX6-induced senescence following by autophagy of CC cells. It has been reported that MAP4K4 not only promotes tumorigenesis and cancer metastasis [43,44] but also mediates the Ras-induced cellular senescence [45]. Therefore, MAP4K4 plays an important role in maintaining cell survival after cell proliferation is inhibited, which ultimately leads to autophagy and subsequent senescence of CC cells.…”

Section: Discussionmentioning

confidence: 99%

MAP4K4 and WT1 mediate SOX6‐induced cellular senescence by synergistically activating the ATF2–TGFβ2–Smad2/3 signaling pathway in cervical cancer

Zheng,

Liu,

Shi

et al. 2024

Molecular Oncology

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SRY‐box transcription factor 6 (SOX6) is a member of the SOX gene family and inhibits the proliferation of cervical cancer cells by inducing cell cycle arrest. However, the final cell fate and significance of these cell‐cycle‐arrested cervical cancer cells induced by SOX6 remains unclear. Here, we report that SOX6 inhibits the proliferation of cervical cancer cells by inducing cellular senescence, which is mainly mediated by promoting transforming growth factor beta 2 (TGFB2) gene expression and subsequently activating the TGFβ2–Smad2/3–p53–p21WAF1/CIP1–Rb pathway. SOX6 promotes TGFB2 gene expression through the MAP4K4–MAPK (JNK/ERK/p38)–ATF2 and WT1–ATF2 pathways, which is dependent on its high‐mobility group (HMG) domain. In addition, the SOX6‐induced senescent cervical cancer cells are resistant to cisplatin treatment. ABT‐263 (navitoclax) and ABT‐199 (venetoclax), two classic senolytics, can specifically eliminate the SOX6‐induced senescent cervical cancer cells, and thus significantly improve the chemosensitivity of cisplatin‐resistant cervical cancer cells. This study uncovers that the MAP4K4/WT1–ATF2–TGFβ2 axis mediates SOX6‐induced cellular senescence, which is a promising therapeutic target in improving the chemosensitivity of cervical cancer.

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Section: Discussionmentioning

confidence: 99%

MAP4K4 and WT1 mediate SOX6‐induced cellular senescence by synergistically activating the ATF2–TGFβ2–Smad2/3 signaling pathway in cervical cancer

Zheng,

Liu,

Shi

et al. 2024

Molecular Oncology

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“…Studies on circRNAs are increasing, as they have been found to play a significant role in the pathological development of GC [ 10 , 20 , 21 ]. Yang et al have found that downregulated circ_0087429 can reverse EMT and inhibit the development of cervical cancer via regulating the miR-5003–3p/OGN axis [22] .…”

Section: Discussionmentioning

confidence: 99%

Exosomal circ50547 as a potential marker and promotor of gastric cancer progression via miR-217/HNF1B axis

Zang,

Wang,

Wang

et al. 2024

Translational Oncology

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“…The oncogenic properties of CORO1C have been described in several types of cancer, including colorectal and liver cancers, non-small cell lung carcinoma, and melanomas [ 31 , 32 , 33 , 34 ]. The regulation of actin dynamics is essential for some disease states, including migration, cell polarity, signal transduction, and intracellular trafficking.…”

Section: Discussionmentioning

confidence: 99%

“…An experimental setting comprised from both in vitro and in vivo studies, demonstrated that CORO1C could promote glioma growth via the Wnt/β-catenin signalling pathway [ 39 ]. The overexpression of CORO1C in aggressive solid tumours such as glioblastomas and head and neck cancers are often associated with its metastatic powers [ 33 ]. In associations between 17 cancer types, the “crown-like” protein has exhibited the highest expression in head and neck cancers and gliomas.…”

Section: Discussionmentioning

confidence: 99%

Deciphering the Role of microRNA Mediated Regulation of Coronin 1C in Glioblastoma Development and Metastasis

Mustafov

Karteris

Braoudaki

2023

ncRNA

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Glioblastoma multiforme (GBM) is a highly heterogenic and malignant brain tumour with a median survival of 15 months. The initial identification of primary glioblastomas is often challenging. Coronin 1C (CORO1C) is a key player in actin rearrangement and cofilin dynamics, as well as enhancing the processes of neurite overgrowth and migration of brain tumour cells. Different bioinformatic databases were accessed to measure CORO1C expression at the mRNA and protein level in normal and malignant brains. CORO1C expression was observed in brain regions which have retained high synaptic plasticity and myelination properties. CORO1C was also expressed mainly within the hippocampus formation, including the Cornu Ammonis (CA) fields: CA1–CA4. Higher expression was also noticed in paediatric GBM in comparison to their adult counterparts. Pediatric cell populations were observed to have an increased log2 expression of CORO1C. Furthermore, 62 miRNAs were found to target the CORO1C gene. Of these, hsa-miR-34a-5p, hsa-miR-512-3p, hsa-miR-136-5p, hsa-miR-206, hsa-miR-128-3p, and hsa-miR-21-5p have shown to act as tumour suppressors or oncomiRs in different neoplasms, including GBM. The elevated expression of CORO1C in high grade metastatic brain malignancies, including GBM, suggests that this protein could have a clinical utility as a biomarker linked to an unfavorable outcome.

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Hsa_circ_0000437 promotes pathogenesis of gastric cancer and lymph node metastasis

Cited by 19 publications

References 44 publications

MAP4K4 and WT1 mediate SOX6‐induced cellular senescence by synergistically activating the ATF2–TGFβ2–Smad2/3 signaling pathway in cervical cancer

MAP4K4 and WT1 mediate SOX6‐induced cellular senescence by synergistically activating the ATF2–TGFβ2–Smad2/3 signaling pathway in cervical cancer

Exosomal circ50547 as a potential marker and promotor of gastric cancer progression via miR-217/HNF1B axis

Deciphering the Role of microRNA Mediated Regulation of Coronin 1C in Glioblastoma Development and Metastasis

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