2015
DOI: 10.1093/brain/awv056
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HS3ST2 expression is critical for the abnormal phosphorylation of tau in Alzheimer’s disease-related tau pathology

Abstract: Heparan sulphate (glucosamine) 3-O-sulphotransferase 2 (HS3ST2, also known as 3OST2) is an enzyme predominantly expressed in neurons wherein it generates rare 3-O-sulphated domains of unknown functions in heparan sulphates. In Alzheimer's disease, heparan sulphates accumulate at the intracellular level in disease neurons where they co-localize with the neurofibrillary pathology, while they persist at the neuronal cell membrane in normal brain. However, it is unknown whether HS3ST2 and its 3-O-sulphated heparan… Show more

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Cited by 82 publications
(105 citation statements)
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“…HS6ST2 is expressed in the brain and believed to play a role in embryonic development. 3-O-sulphated heparan sulphates produced by a similar sulfotransferase, HS3ST2, have been reported to act as molecular chaperones allowing the abnormal phosphorylation of tau in Alzheimer's disease (3). Considering that the structure of this gene is disrupted by the larger duplication in our case, its potential pathological effect on brain development cannot be ruled out.…”
Section: Letter To the Editormentioning
confidence: 84%
“…HS6ST2 is expressed in the brain and believed to play a role in embryonic development. 3-O-sulphated heparan sulphates produced by a similar sulfotransferase, HS3ST2, have been reported to act as molecular chaperones allowing the abnormal phosphorylation of tau in Alzheimer's disease (3). Considering that the structure of this gene is disrupted by the larger duplication in our case, its potential pathological effect on brain development cannot be ruled out.…”
Section: Letter To the Editormentioning
confidence: 84%
“…ARHGAP18 in Cluster 18, CDC42BPA in Cluster 3, CXCL12 in Cluster 8, and HS3ST2 in Cluster 5 previously reported with schizophrenia (45)(46)(47)(48); KCTD12 in Cluster 9 and PSAT1 in Cluster 8 previously reported with depressive disorder (49,50); ADAMTS1 in Cluster 10, DOCK2 in Cluster 10, HS3ST2 in Cluster 5, NAMPT in Cluster 5, and NAV in Cluster 5 previously reported with Alzheimer's disease (51)(52)(53)(54)(55); and PEX10 in Cluster 11 previously reported with Down syndrome (56).…”
Section: Gene Interpretationmentioning
confidence: 94%
“…Despite these difficulties, some information has emerged. It is known that physiological cation concentrations can affect heparin/ HS activity significantly [131] and can vary, for example, for K þ from 3.0 mM extracellularly to 150 mM intracellularly which may be relevant if HS can gain entry into the cell, as has been suggested [132]. However, it is likely that, for example in the vicinity of ion channels, considerable variation in local concentration could prevail.…”
Section: Cation Binding To Heparan Sulfate/heparin and Its Effectsmentioning
confidence: 99%