HS-10182, an EGFR Tyrosine Kinase Inhibitor, Increases Radiation Sensitivity in Non-Small Cell Lung Cancer With EGFR T790M Mutation

Abstract

The median GTV at about 30 days after the beginning of X-irradiation compared with that before treatment was 70.2% (48.8-92.7, CDDP and S-1) and 72.3% (28.8-92.6, CDDP and vinorelbine), respectively. At 30 days, the shrinkage rates of GTV after CCPT were significantly higher than those after CCRT using either regimen of chemotherapy. Conclusion: CCPT using CDDP and S-1 is considered to be very effective in obtaining a favorable primary response. The treatment appeared to have a strong tumor-shrinking effect during an early period. Frequent verification and adaptive plan making according to a verification plan are considered necessary. Further investigation with more patients and more detailed evaluation seems to be warranted.