HRT and heart disease: problems and prospects

Maas, Angela H.E.M.; Graaf, Yolanda van der; Schouw, Yvonne T. van der; Grobbee, Diederick E.

doi:10.1016/j.maturitas.2003.10.012

Cited by 10 publications

(4 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Such protective effects of twinning could be hypothesized to be brought about by higher levels of estrogens (by means of elevated follicle-stimulating hormone levels) among reproductive-age mothers who delivered twins, which may in turn reduce the risk of cardiovascular diseases later in life (reviewed in refs. 43,44). If mothers of twins turn out to have lower mortality from cardiovascular diseases also in contemporary populations, this might have medical significance, because cardiovascular diseases are a major cause of death in the developed world.…”

Section: Discussionmentioning

confidence: 99%

Accelerated immunosenescence in preindustrial twin mothers

Helle

Lummaa

Jokela

2004

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

Life-history theory predicts a tradeoff between reproductive effort and lifespan. It has been suggested that this tradeoff is a result of reproductive costs accelerating senescence of the immune system, leading to earlier death. Longevity costs of reproduction are suggested for some human populations, but whether high reproductive effort leads to impaired immune function is unknown. We examined how reproductive effort affected postreproductive survival and the probability of dying of an infectious disease in women born in preindustrial Finland between 1702 and 1859. We found that mothers delivering twins had reduced postreproductive survival after age 65. This effect arose because mothers of twins had a higher probability of succumbing to an infectious disease (mainly tuberculosis) than mothers delivering singletons. The risk among mothers of twins of dying of an infectious disease was further elevated if mothers had started reproducing early. In contrast, neither female postreproductive survival nor the risk of succumbing to an infectious disease was influenced by the total number of offspring produced. Our results provide evidence of a long-term survival cost of twinning in humans and indicate that the mechanism mediating this cost might have been accelerated immunosenescence.immune function ͉ cost of reproduction ͉ longevity ͉ reproductive effort ͉ tuberculosis

show abstract

Section: Discussionmentioning

confidence: 99%

Accelerated immunosenescence in preindustrial twin mothers

Helle

Lummaa

Jokela

2004

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

show abstract

“…However, bisphosphonates, the most common anti-absorbent agents, can inhibit bone turnover, impair the natural mechanism of bone repair, and increase the risk of adverse complications such as jaw necrosis and atypical fractures. Furthermore, the efficacy of hormone replacement therapy decreases over time, and long-term treatment increases the risk of reproductive malignancies, cardiovascular diseases, and serious sequelae [ 5 , 6 ]. Therefore, developing a new treatment method for OP is crucial.…”

Section: Introductionmentioning

confidence: 99%

NIR-Triggered Release of Nitric Oxide by Upconversion-Based Nanoplatforms to Enhance Osteogenic Differentiation of Mesenchymal Stem Cells for Osteoporosis Therapy

Ma,

Luan,

Zhao

et al. 2024

Biomater Res

View full text Add to dashboard Cite

Stem cell therapy is an attractive approach to bone tissue regeneration in osteoporosis (OP); however, poor cell engraftment and survival within injured tissues limits its success in clinical settings. Nitric oxide (NO) is an important signaling molecule involved in various physiological processes, with emerging evidence supporting its diverse roles in modulating stem cell behavior, including survival, migration, and osteogenic differentiation. To control and enhance osteogenic differentiation of mesenchymal stem cells (MSCs) for OP therapy, we designed a near-infrared (NIR) light-triggered NO-releasing nanoplatform based on upconversion nanoparticles (UCNPs) that converts 808-nm NIR light into visible light, stimulating NO release by light control. We demonstrate that the UCNP nanoplatforms can encapsulate a light-sensitive NO precursor, Roussin’s black salt (RBS), through the implementation of a surface mesoporous silica coating. Upon exposure to 808-nm irradiation, NO is triggered by the controlled upconversion of UCNP visible light at the desired time and location. This controlled release mechanism facilitates photoregulated differentiation of MSCs toward osteogenic lineage and avoids thermal effects and phototoxicity on cells, thus offering potential therapeutic applications for treating OP in vivo. Following the induction of osteogenic differentiation, the UCNP nanoplatforms exhibit the capability to serve as nanoprobes for the real-time detection of differentiation through enzymatic digestion and fluorescence recovery of UCNPs, enabling assessment of the therapeutic efficacy of OP treatment. Consequently, these UCNP-based nanoplatforms present a novel approach to control and enhance osteogenic differentiation of MSCs for OP therapy, simultaneously detecting osteogenic differentiation for evaluating treatment effectiveness.

show abstract

“…Estrogen exerts beneficial effects on blood lipids, lowdensity lipoprotein (LDL)/high-density lipoprotein (HDL) ratio, plasma triacylglycerol, and vascular function. [1][2][3][4] Recently, the cardiovascular benefits of hormone replacement therapy have been questioned, [5][6][7][8] and such therapy is no longer considered a viable option for reducing CVD in postmenopausal women. Therefore, other means of modulating cholesterol and reducing the risk of CVD in the absence of estrogen are desirable.…”

Section: Introductionmentioning

confidence: 99%

Effect of Vitamin E on Lipid Parameters in Ovariectomized Rats

Lucas

Chen

Chai

et al. 2006

Journal of Medicinal Food

View full text Add to dashboard Cite

The risk of cardiovascular disease drastically increases at the onset of menopause, in part, because of rise in blood cholesterol and unfavorable changes in lipid profile. This study was designed to investigate the dose-dependent effects of vitamin E supplementation on lipid parameters in ovariectomized (ovx) rats. Sixty 12-month-old female Sprague-Dawley rats were either sham-operated (sham; one group) or ovx (four groups). All rats were maintained on a semipurified caseinbased diet (AIN-93M; 75 IU vitamin E/kg of diet) for a period of 120 days. Thereafter, ovx rats were placed on one of four doses of vitamin E treatment (75, 300, 525, or 750 IU vitamin E/kg of diet), while the sham group was continued on 75 IU vitamin E/kg of diet for 100 days. Ovariectomy tended to increase (by 24%, P = 0.1) serum non?high-density lipoprotein (HDL) cholesterol and decrease (by 14%, P = 0.1) HDL cholesterol. Vitamin E did not have any significant effects on serum lipid parameters. Liver total lipids were notably increased (P < .001) in ovx animals, and supplementation with vitamin E at 525 IU/kg of diet was able to significantly reduce liver total lipids by 13%. Additionally, ovariectomy caused an increase in serum glucose and liver C18:1 fatty acid concentrations along with decreases in C18:0, C20:4, and C22:6 fatty acid concentrations. These alterations on liver fatty acid profiles were unaffected by vitamin E. The findings of this study suggest that vitamin E supplementation moderately improves lipid parameters in ovarian hormone-deficient rats.

show abstract

HRT and heart disease: problems and prospects

Cited by 10 publications

References 41 publications

Accelerated immunosenescence in preindustrial twin mothers

Accelerated immunosenescence in preindustrial twin mothers

NIR-Triggered Release of Nitric Oxide by Upconversion-Based Nanoplatforms to Enhance Osteogenic Differentiation of Mesenchymal Stem Cells for Osteoporosis Therapy

Effect of Vitamin E on Lipid Parameters in Ovariectomized Rats

Contact Info

Product

Resources

About