HR-HPV DNA to differentiate between cervical pemphigus and CIN: a case report

Karanjgaokar, V.; Khan, Ayesha; Ramachandra, Su; Pisal, Narendra

doi:10.1007/s00404-007-0467-5

Cited by 1 publication

(6 citation statements)

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“…A differential diagnosis between PV and cervical neoplasia might be possible but a biopsy remains advisable . Tests to detect HPV DNA have been used for differentiation and are also recommended when following up PV patients . In our case report, HPV DNA investigation was negative.…”

Section: Discussionmentioning

confidence: 66%

“…However, some patients remain asymptomatic despite presenting with a positive Nikolsky's sign in the cervix, suggesting that cervical involvement, albeit silent, is frequent during the active stage of PV . In the cytological assessment, acantholytic cells are found both in isolation and/or in small clusters and feature round nuclei of increased volume, inconspicuous nucleoli, and perinuclear halos …”

Section: Discussionmentioning

confidence: 99%

“…The oral mucosa is affected most commonly, often followed by skin involvement . More rarely, other sites such as the vulva, vagina, cervix, urethra, anus, pharynx, larynx, and esophagus can be affected . Cervical involvement, the frequency of which remains unknown, has been rarely reported and there is little information about the criteria regarding the consequential changes observed in correlated Papanicolaou‐stained cervicovaginal smears (Pap smears) .…”

mentioning

confidence: 99%

“…Cervical involvement, the frequency of which remains unknown, has been rarely reported and there is little information about the criteria regarding the consequential changes observed in correlated Papanicolaou‐stained cervicovaginal smears (Pap smears) . Therefore, difficulties associated with the identification and interpretation of acantholytic cells in Pap tests might be responsible for false‐positive diagnoses of cervical neoplasia . However, a suspected diagnosis of PV can be confirmed if the cytological findings are carefully correlated with the patient's medical history and clinical and colposcopy test results, thus enabling a proper referral of the patient for treatment …”

mentioning

confidence: 99%

“…Therefore, difficulties associated with the identification and interpretation of acantholytic cells in Pap tests might be responsible for false‐positive diagnoses of cervical neoplasia . However, a suspected diagnosis of PV can be confirmed if the cytological findings are carefully correlated with the patient's medical history and clinical and colposcopy test results, thus enabling a proper referral of the patient for treatment …”

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confidence: 99%

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Pemphigus vulgaris of the cervix: Diagnostic difficulties associated with the Pap test

Coelho

Stall²,

França

et al. 2015

Diagnostic Cytopathology

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Pemphigus vulgaris (PV) is a rare mucocutaneous disease caused by the abnormal production of antibodies against epithelial cell surface glycoproteins, resulting in loss of cell adhesion and intraepithelial blister formation. Cervical involvement in PV has been poorly reported, and there is little information regarding the criteria about consequential cytological changes identified in a Papanicolaou-stained cervicovaginal smear (Pap smear). Here, we report a case of PV manifesting in the cervix as well as the difficulty associated with the cytomorphological identification and interpretation of acantholytic cells. This case involved a 40-year-old patient with no history of Pap test abnormalities and no prior diagnosis of PV. In the cytological assessment, cells were identified both in isolation and in clusters that exhibited round nuclei of increased volume, inconspicuous nucleoli, and perinuclear halos. The patient underwent a cervical biopsy that revealed vesiculobullous lesions and morphological pattern consistent with PV. A skin biopsy confirmed this diagnosis. We concluded that knowledge of PV cytomorphology is important because difficulties associated with the identification and interpretation of acantholytic cells might be responsible for false positive diagnoses of cervical neoplasia. However, a suspected diagnosis of PV is possible if the cytological findings are carefully correlated with the clinical data.

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Section: Discussionmentioning

confidence: 66%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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confidence: 99%

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