HPV vaccine uptake in men who have sex with men in Scotland

Pollock, Kevin G; Wallace, Lynn; Wrigglesworth, S.; McMaster, Dorothy; Steedman, N

doi:10.1016/j.vaccine.2018.11.081

Cited by 23 publications

(19 citation statements)

References 6 publications

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“…[37][38][39][40][53][54][55] While improved screening strategies are essential for successful AIN prevention programmes, patient participation is equally important. 56 For this reason, further efforts should be made to encourage both male and female PLWH to take part in screening and prevention programmes.…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, we suggest that HPV vaccination especially for MSM and PLWH with high‐risk behaviour should be a part of future prevention strategies . While improved screening strategies are essential for successful AIN prevention programmes, patient participation is equally important . For this reason, further efforts should be made to encourage both male and female PLWH to take part in screening and prevention programmes.…”

Section: Discussionmentioning

confidence: 99%

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Evaluation of anal carcinoma screening in male and female HIV patients at an interdisciplinary HIV therapy centre

Todorova

Schwierzeck

Turek

et al. 2019

Acad Dermatol Venereol

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Background Incidence of anal carcinoma is increased in people living with HIV (PLWH). Due to the improved life expectancy in PLWH, identifying appropriate prevention strategies for non‐AIDS‐defining cancer types such as anal carcinoma has become a priority in managing PLWH today. Objective We aimed to evaluate anal cytology assessment as screening tool for anal dysplasia and/or carcinoma in PLWH, regardless of gender or sexual orientation. Additionally, we investigated the correlation between cancer risk factors and abnormal screening results in our patient cohort. Methods People living with HIV from the Interdisciplinary HIV Centre of the University Hospital rechts der Isar in Munich, Germany (IZAR), were screened for anal carcinoma by single cytobrush examination and anal Papanicolaou (PAP) smear assessment from 2013 to 2015. Patients with abnormal PAP smear result were offered a follow‐up examination after 12 months. Differences between two groups were tested for statistical significance using Student's t‐test and Mann–Whitney U‐test, as appropriate. Results In total, 101 PLWH were included. 26.7% of subjects (n = 27) were PAP IIID, and 9.9% (n = 10) were PAP IVa. Seven female subjects had an abnormal finding at screening. Smoking was significantly associated with abnormal findings at screening (P = 0.005). In addition, our study found an association between sexually transmitted infections (STI) and anal dysplasia. Condylomata acuminata were increased in subjects with PAP IIID/PAP IVa (P = 0.045). Reactive syphilis serology was found to be significantly associated with abnormal screening results (P = 0.016), respectively. Conclusion Our results demonstrate that smoking and two common STIs, condylomata acuminata and syphilis, are risk factors associated with advanced anal intraepithelial neoplasia (AIN) stages in our PLWH cohort. While further analysis is needed to determine diagnostic guidelines concerning AIN in PLWH, these results suggest that interdisciplinary lifestyle prevention strategies are required to reduce the risk factors for AIN in PLWH in an outpatient setting.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Evaluation of anal carcinoma screening in male and female HIV patients at an interdisciplinary HIV therapy centre

Todorova

Schwierzeck

Turek

et al. 2019

Acad Dermatol Venereol

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“…Thus, once a successful HPV-vaccination program for girls has been established, targeted HPV vaccination for MSM appears as the next priority for the prevention of HPV-related malignancies [27]. Pollock et al [28] recently studied the HPV vaccine uptake in MSM in Scotland in an opportunistic program, with vaccination being offered in the sexual health clinic setting. They concluded that the first-dose uptake was moderately high, but suggested that gender-neutral immunization would be preferable to MSM-targeted vaccination, reducing stigma and inequality.…”

Section: Discussionmentioning

confidence: 99%

On the Elimination of Cancers Related to Oncogenic Human Papillomavirus: an Approach using a Computational Network Model

Muñoz-Quiles¹,

Díez-Domingo²,

Acedo³

et al. 2021

Preprint

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Cervical cancer is the fourth most common malignancy in women worldwide, although it is preventable with prophylactic HPV vaccination. HPV transmission-dynamic models can predict the potential for global elimination of cervical cancer. The random network model is a new approach that allows individuals to be followed, and to implement a given vaccination policy according to their clinical records. We developed an HPV transmission dynamics model on a lifetime sexual partners network based on individual contacts, also accounting for the sexual behavior of men who have sex with men (MSM). We analyzed the decline in the prevalence of HPV infection in a scenario of 75% and 90% coverage for both sexes. An important herd immunity effect for men and women was observed in the heterosexual network, even with 75% coverage. However, HPV in-fections are persistent in the MSM population, with sustained circulation of the virus among un-vaccinated individuals. Coverage around 75% of both sexes would be necessary to eradicate HPV-related conditions in women within five decades. Nevertheless, the variation in the decline in infection in the long term between vaccination coverage of 75% and 90% is relatively small, suggesting that reaching coverage of around 70-75% in the heterosexual network may be enough to confer high protection. Nevertheless, HPV eradication maybe achieved if men’s coverage is strictly controlled. This accurate representation of HPV transmission demonstrates the need to maintain high HPV vaccination coverage, especially in men, for whom the cost-effectiveness of vaccination is questioned.

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“…The uptake of free HPV vaccination provided by national programs was 37.6% among MSM in the United States [24], 42.6% in Australia [21], 49.1% in England [25], and 63.7% in Scotland [20]. HPV vaccination uptake among the male population is very low in Hong Kong [26], and previous studies have reported zero uptake among MSM [27,28].…”

Section: Introductionmentioning

confidence: 85%

“…As a result, the US Centers for Disease Control and Prevention (CDC) recommends MSM who are in the age range of 45 years or below to receive HPV vaccination [13,18]. Free national HPV vaccination programs for MSM aged up to 45 years attending sexual health and HIV clinics rolled out in England and Scotland in 2018 and 2017, respectively [19,20]. The Victorian Government of Australia funded a free time-limited HPV vaccination catch-up program for MSM aged up to 26 years in 2017 [21].…”

Section: Introductionmentioning

confidence: 99%

Two Web-Based and Theory-Based Interventions With and Without Brief Motivational Interviewing in the Promotion of Human Papillomavirus Vaccination Among Chinese Men Who Have Sex With Men: Randomized Controlled Trial (Preprint)

Wang¹,

Lau²,

Ip³

et al. 2020

Preprint

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BACKGROUND Men who have sex with men (MSM) are at high risk of contracting Human papillomavirus (HPV) and its related diseases. HPV vaccination is highly effective in preventing vaccine-type genital warts and cancers among MSM. OBJECTIVE The primary objective of this randomized controlled trial (RCT) was to evaluate the relative efficacies of two online, theory-based interventions with and without brief motivational interviewing (MI) over the phone in increasing HPV vaccination completion (receipt of three required doses) within a 24-month follow-up period, as compared to the control group. METHODS A three-arm parallel-group RCT was conducted between July 2017 and December 2019. Five telephone surveys were conducted at Baseline, Month 3, 6, 9 & 24 by blinded interviewers. Participants were Hong Kong Chinese speaking MSM aged 18 to 45 years having regular Internet access. Those who had ever received HPV vaccination were excluded. A total of 624 participants were randomized into either the Group HC (n=208), the Group HC-MI (n=208), and the control group (n=208); 459 (73.6%) completed follow-up evaluation at Month 24. Participants in the Group HC received an online tutorial developed based on the Health Belief Model. On top of the same online tutorial, the Group HC-MI received brief MI over the phone. Reminders were sent to participants of the Group HC and Group HC-MI 1, 2, 4, 6 and 8 months afterwards. Participants in the control group received online health communication messages irrelevant to HPV or HPV vaccination. The research team validated self-reported HPV vaccination uptake. Intention-to-treat analysis was used for outcome analyses. Logistic regression models and linear regression models were used to test the between-group differences in primary and secondary outcomes. Baron and Kenny’s methods were used to test the mediation hypothesis. RESULTS Participants in the Group HC-MI reported significantly higher validated completion of HPV vaccination at Month 24 than the control group [17.3% (36/208) versus 7.2% (15/208), adjusted odds ratios (AOR): 1.57, 95%CI: 1.14, 2.17, p=.006]. However, the difference in HPV vaccination completion between the Group HC and the control group (p=.17), or between the Group HC-MI and the Group HC (p=.13) was not statistically significant. The association between randomization status (Group HC-MI versus control) and HPV vaccination completion became statistically non-significant (from p=.006 to p=.06) after controlled for changes in perceived susceptibility to HPV/HPV-related diseases (Month 24 versus baseline), whereas perceived susceptibility remained strongly associated with HPV vaccination uptake in the model (p<.001). The results suggested that change in perceived susceptibility fully mediated the intervention effect. CONCLUSIONS The theory-based online tutorial with brief MI over the phone was effective in increasing HPV vaccination completion among MSM in Hong Kong, China. Perceived susceptibility was an active theoretical component leading to behavioral changes. Local and international dissemination and implementation research are greatly warranted. CLINICALTRIAL ClinicalTrial.gov, number NCT03286907

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HPV vaccine uptake in men who have sex with men in Scotland

Cited by 23 publications

References 6 publications

Evaluation of anal carcinoma screening in male and female HIV patients at an interdisciplinary HIV therapy centre

Evaluation of anal carcinoma screening in male and female HIV patients at an interdisciplinary HIV therapy centre

On the Elimination of Cancers Related to Oncogenic Human Papillomavirus: an Approach using a Computational Network Model

Two Web-Based and Theory-Based Interventions With and Without Brief Motivational Interviewing in the Promotion of Human Papillomavirus Vaccination Among Chinese Men Who Have Sex With Men: Randomized Controlled Trial (Preprint)

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