HPV vaccine acceptability among men: a systematic review and meta-analysis

Abstract

ObjectiveTo understand rates of human papillomavirus (HPV) vaccine acceptability and factors correlated with HPV vaccine acceptability.DesignMeta-analyses of cross-sectional studies.Data sourcesWe used a comprehensive search strategy across multiple electronic databases with no date or language restrictions to locate studies that examined rates and/or correlates of HPV vaccine acceptability. Search keywords included vaccine, acceptability and all terms for HPV.Review methodsWe calculated mean HPV vaccine acceptability across studies. We conducted meta-analysis using a random effects model on studies reporting correlates of HPV vaccine acceptability. All studies were assessed for risk of bias.ResultsOf 301 identified studies, 29 were included. Across 22 studies (n=8360), weighted mean HPV vaccine acceptability=50.4 (SD 21.5) (100-point scale). Among 16 studies (n=5048) included in meta-analyses, perceived HPV vaccine benefits, anticipatory regret, partner thinks one should get vaccine and healthcare provider recommendation had medium effect sizes, and the following factors had small effect sizes on HPV vaccine acceptability: perceived HPV vaccine effectiveness, need for multiple shots, fear of needles, fear of side effects, supportive/accepting social environment, perceived risk/susceptibility to HPV, perceived HPV severity, number of lifetime sexual partners, having a current sex partner, non-receipt of hepatitis B vaccine, smoking cigarettes, history of sexually transmitted infection, HPV awareness, HPV knowledge, cost, logistical barriers, being employed and non-white ethnicity.ConclusionsPublic health campaigns that promote positive HPV vaccine attitudes and awareness about HPV risk in men, and interventions to promote healthcare provider recommendation of HPV vaccination for boys and mitigate obstacles due to cost and logistical barriers may support HPV vaccine acceptability for men. Future investigations employing rigorous designs, including intervention studies, are needed to support effective HPV vaccine promotion among men.

HPV vaccine acceptability in HIV-infected and HIV negative men who have sex with men (MSM) in Ireland

“…20,21,22 This may be due to poor knowledge relating to HPV infection, HPV associated disease and HPV vaccine in MSM in Ireland.…”

“…While this was not examined in our study it should be considered when education programs are being developed. 20 Perception that HPV vaccine will protect against genital warts, penile and anal cancers were associated with HPV vaccine acceptability on univariate analysis (Table 5) As factors reported as associated with HPV vaccine acceptability are based on the scenario of no cost vaccine, perception that market cost of the vaccine is high may attribute a value to the vaccine and represent an incentive to avail of no cost vaccine.…”

Awareness and acceptance of human papillomavirus (HPV) vaccination among males attending a major sexual health clinic in Wuxi, China: A cross-sectional study

“…Our figure on the acceptance of HPV vaccine among MSM was lower than that in a recently published systematic review on data from various countries (36-74%). 36 This may be because of the lack of knowledge of HPV vaccine and the perception that HPV vaccine was a female vaccine and irrelevant to men. 36 Younger MSM may be more accepting of HPV vaccination.…”

“…36 This may be because of the lack of knowledge of HPV vaccine and the perception that HPV vaccine was a female vaccine and irrelevant to men. 36 Younger MSM may be more accepting of HPV vaccination. An Australian study of 200 MSM aged 16 to 20 found that of these young men 86% would be willing to take the vaccine if it was free of charge to MSM, albeit only 30% would purchase it.…”

Human papillomavirus: a strong case for vaccinating boys

“…In a study of 4065 males aged 16-26, the quadrivalent HPV vaccine was shown to be effective in preventing genital warts, penile cancer and anal cancer. 1,9 In addition, a meta-analysis of 29 studies (8360 men) that reported on HPV vaccine acceptability found a moderate level of acceptability in men, 10 indicating that men would have the HPV vaccine if it was offered.…”