HPV vaccination and HPV-related malignancies: impact, strategies and optimizations toward global immunization coverage

Giannone, Gaia; Giuliano, Anna R.; Bandini, Marco; Marandino, Laura; Raggi, Daniele; Earle, Wayne; Ayres, B.; Pettaway, Curtis A.; McNeish, Iain A.; Spiess, Philippe E.; Necchi, Andrea

doi:10.1016/j.ctrv.2022.102467

Cited by 19 publications

(13 citation statements)

References 89 publications

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“…Messages containing either a relative cancer risk or relative HPV risk statistic (e.g., “Compared to women, men are about three times more likely to get oral HPV, which causes deadly mouth and throat cancer.”) were perceived as attention grabbing and provided participants with novel information. Paired with the sample’s low awareness about their risk for contracting HPV, these results add to previous literature ( Alaraj et al, 2023 ; Giannone et al, 2022 ; Laserson et al, 2020 ) suggesting messages communicating HPV-related cancer risk to men should likely use language aimed at increasing their perceived risk relevance of HPV and cancer.…”

Section: Discussionsupporting

confidence: 65%

“…We report participant age and race based on demographic data provided by Prolific. Since previous research has documented low HPV knowledge and awareness among young adult men ( Giannone et al, 2022 ; Laserson et al, 2020 ), we assessed this among our sample with five questions. First, participants were asked if they had ever heard of HPV (yes/no) and if they had ever heard of the HPV vaccine (yes/no).…”

Section: Methodsmentioning

confidence: 99%

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Perceptions of HPV-Linked Oropharyngeal Cancer Risk Messages Among a Sample of Young Adult Men in the US: A Pilot Study

Harrell,

Kueppers,

Vanderpool

et al. 2024

Am J Mens Health

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Awareness of risk for oropharyngeal cancer from oral human papillomavirus (HPV) infection is low among men in the United States. This pilot study tested messages communicating oral HPV and oropharyngeal cancer risk among a sample of U.S. young adult men (aged 18–26). Six oral HPV and cancer risk messages were tested in an online survey. Participants ( N = 68) were randomly assigned to one of two message sets, each containing three unique text-based messages. Participants evaluated messages separately based on various measures (e.g., perceived message effectiveness [PME], novelty). One-way repeated measures ANOVAs were used to assess evaluation differences within message sets. Participants provided open-ended feedback about each message, which were synthesized into overarching themes. Participants were receptive to the risk messages, rating them high on PME (mean range = 3.72–4.25 out of 5) and other measures. Analyses identified three high-performing messages. For example, participants rated a message about HPV-linked oropharyngeal cancer risk rates in men versus women higher on attention and novelty than two other messages in the same set (both ps < .05). Participants were shown three messages (instead of all six) in each message set to minimize survey fatigue. Common themes from open-ended feedback were that participants liked the short-form structure of the messages and that the messages used gender-tailored language. In conclusion, oral HPV and oropharyngeal cancer risk messages may be useful for increasing risk awareness among men in the U.S. Further work should test such messages in rigorous experimental contexts to assess their efficacy in modifying other health outcomes, such as HPV vaccination behaviors.

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Section: Discussionsupporting

confidence: 65%

Section: Methodsmentioning

confidence: 99%

Perceptions of HPV-Linked Oropharyngeal Cancer Risk Messages Among a Sample of Young Adult Men in the US: A Pilot Study

Harrell,

Kueppers,

Vanderpool

et al. 2024

Am J Mens Health

View full text Add to dashboard Cite

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“…Nonetheless, several studies in this review articulated the importance of gender-neutral HPV vaccination and providing information related to male susceptibility to HPV in the digital interventions to nudge boys to adopt the vaccination behavior [ 35 , 38 , 47 , 48 ]. Digital tools and social media platforms are increasingly exploited in the public health arena to increase awareness and acceptance of vaccination [ 78 ]. As part of this transformation, developers of digital interventions for HPV vaccination should consider tailoring design elements and content of the interventions to the gender of users to align with the recommended universal HPV vaccination [ 42 , 48 ].…”

Section: Discussionmentioning

confidence: 99%

Digital Health Interventions to Improve Adolescent HPV Vaccination: A Systematic Review

et al. 2023

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Digital technologies are being increasingly utilized in healthcare to provide pertinent and timely information for primary prevention, such as vaccination. This study aimed to conduct a systematic review to describe and assess current digital health interventions to promote HPV vaccination among adolescents and parents of adolescents, and to recommend directions for future interventions of this kind. Using appropriate medical subject headings and keywords, we searched multiple databases to identify relevant studies published in English between 1 January 2017 and 31 July 2022. We screened and selected eligible studies for inclusion in the final analysis. We reviewed a total of 24 studies, which included interventions using text messages (4), mobile apps (4), social media and websites (8), digital games (4), and videos (4). The interventions generally improved determinants of HPV vaccination, such as HPV-related knowledge, vaccine-related conversations, and vaccination intentions. In particular, text message and social media interventions targeted improved vaccine uptake behaviors, but little meaningful change was observed. In conclusion, digital health interventions can cost-effectively provide education about HPV vaccination, offer interactive environments to alleviate parental vaccine hesitancy, and ultimately help adolescents engage in HPV vaccine uptake.

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“…Viral infections were the root cause of many human cancers. When it comes to human papillomavirus (HPV), we considered it to be primarily related to cervical cancer [ 71 ]. The involvement of HPV in the development of various malignancies, such as vaginal, vulvar, anal and oropharyngeal cancers have lately been studied [ 72 – 74 ].…”

Section: Types Of Adoptive Cell Therapymentioning

confidence: 99%

The potential and promise for clinical application of adoptive T cell therapy in cancer

Li,

Zheng,

Liu

et al. 2024

J Transl Med

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Adoptive cell therapy has revolutionized cancer treatment, especially for hematologic malignancies. T cells are the most extensively utilized cells in adoptive cell therapy. Currently, tumor-infiltrating lymphocytes, T cell receptor-transgenic T cells and chimeric antigen receptor T cells are the three main adoptive T cell therapies. Tumor-infiltrating lymphocytes kill tumors by reinfusing enlarged lymphocytes that naturally target tumor-specific antigens into the patient. T cell receptor-transgenic T cells have the ability to specifically destroy tumor cells via the precise recognition of exogenous T cell receptors with major histocompatibility complex. Chimeric antigen receptor T cells transfer genes with specific antigen recognition structural domains and T cell activation signals into T cells, allowing T cells to attack tumors without the assistance of major histocompatibility complex. Many barriers have been demonstrated to affect the clinical efficacy of adoptive T cell therapy, such as tumor heterogeneity and antigen loss, hard trafficking and infiltration, immunosuppressive tumor microenvironment and T cell exhaustion. Several strategies to improve the efficacy of adoptive T cell therapy have been explored, including multispecific chimeric antigen receptor T cell therapy, combination with immune checkpoint blockade, targeting the immunosuppressive tumor microenvironment, etc. In this review, we will summarize the current status and clinical application, followed by major bottlenecks in adoptive T cell therapy. In addition, we will discuss the promising strategies to improve adoptive T cell therapy. Adoptive T cell therapy will result in even more incredible advancements in solid tumors if the aforementioned problems can be handled. Graphical abstract

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HPV vaccination and HPV-related malignancies: impact, strategies and optimizations toward global immunization coverage

Cited by 19 publications

References 89 publications

Perceptions of HPV-Linked Oropharyngeal Cancer Risk Messages Among a Sample of Young Adult Men in the US: A Pilot Study

Perceptions of HPV-Linked Oropharyngeal Cancer Risk Messages Among a Sample of Young Adult Men in the US: A Pilot Study

Digital Health Interventions to Improve Adolescent HPV Vaccination: A Systematic Review

The potential and promise for clinical application of adoptive T cell therapy in cancer

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