HPV-specific antibodies at the oral cavity up to 30 months after the start of vaccination with the quadrivalent HPV vaccine among mid-adult aged men

To Vaccinate or Not to Vaccinate: Should Adults Aged 26 to 45 Years Receive the Human Papillomavirus Vaccine?

“…Antibodies against HPV 16 and 18 in the oral cavity (samples obtained from oral rinses) and serum peaked at 1 month after completing the three‐dose vaccine series, and although those in the oral cavity decreased over time, seropositivity persisted for 2 years after vaccination in 98% and 80% of individuals against HPV types 16 and 18, respectively. This study illustrated that the HPV vaccine generated a durable immune response even in adult men 5 …”

“…This study illustrated that the HPV vaccine generated a durable immune response even in adult men. 5…”

“…Based on studies of the previously available bivalent and quadrivalent HPV vaccines, the current HPV vaccine is safe and proves efficacious in both adult women and men aged over 26 years, even in individuals with prior HPV exposure. [3][4][5] In the gynecologic literature, the HPV vaccine also demonstrates the potential to reduce the recurrence of precancerous lesions caused by HPV infection. 4 At current levels of HPV vaccine uptake in the eligible young adult population, especially the low rate in men, the impact of the vaccine on oral HPV prevalence is limited with regard to rising incidence of HPV-associated oropharyngeal cancers.…”

“…Parker et al reported findings of the multi‐institutional Mid‐Adult Men Trial Study of 150 men aged 27 to 45 years who were immunized with the quadrivalent HPV vaccine and followed for 30 months 5 . Antibodies against HPV 16 and 18 in the oral cavity (samples obtained from oral rinses) and serum peaked at 1 month after completing the three‐dose vaccine series, and although those in the oral cavity decreased over time, seropositivity persisted for 2 years after vaccination in 98% and 80% of individuals against HPV types 16 and 18, respectively.…”

“…One randomized controlled trial 3 (level 1); one prospective cohort study, 5 one retrospective cross‐sectional analysis of survey data, 2 and one retrospective cohort study (level 2) 4 ; and one statement of expert opinion (level 5) 1 …”