HPV Self-Sampling for Cervical Cancer Screening Among Ethnic Minority Women in South Florida: a Randomized Trial

Abstract

Clinical Trials.gov Identifier: NCT02121548.

A randomized trial of mailed HPV self-sampling for cervical cancer screening among ethnic minority women in South Florida

“…Our findings upheld that HPV self-sampling was superior to navigating women to low cost Pap smears at Federally Qualified Health Centers or free clinics within their community of residence (77% HPV self-sampling completion vs. 43% Pap smear completion, respectively) [16]. Given such findings, we sought to further examine the most optimal strategies for delivering HPV self-sampling to these three underserved communities, as well as others similarly characterized by health disparity and lack of access to the formal healthcare system.…”

Participation in Cervical Screening by Self-collection, Pap, or a Choice of Either in Brazil

“…The higher preference for self-collection in our study may be attributed to convenience of being recruited at home where they could get their own sampling (94.7% did it on the same day). In contrast, in the study by Carrasquillo and colleagues (35), participants were recruited at community venues (e.g., stores, community centers) in which it may have been harder to engage in self-collection for HPV testing at the time of recruitment.…”

“…16). Comparatively, in an individual-based randomized trial of education versus patient navigation versus choice of Pap versus self-collection conducted in unscreened/underscreened women living in Southern Florida, women assigned to the Choice arm had a 77.3% overall participation and 64.3% chose self-collection (35). The higher preference for self-collection in our study may be attributed to convenience of being recruited at home where they could get their own sampling (94.7% did it on the same day).…”

“…Extracted specimens (2-5 mL of the eluted DNA) were tested for high-risk HPV DNA using the cobas HPV test (Roche Molecular Systems) run on the fully automated cobas 4800 testing platform. The cobas HPV test is a DNA test for high-risk HPV, and the results are reported in three separate channels: HPV16 individually, HPV18 individually, and a pool of 12 other high-risk HPV genotypes [11 definite high-risk, cancer-associated, HPV types (HPV31, 33,35,39,45,51,52,56,58,59, and 68) plus one possibly HPV genotype (HPV66)]. A fourth channel measures b-globin for specimen adequacy.…”

Determinants for Participation in Human Papillomavirus Self-Sampling among Nonattenders to Cervical Cancer Screening in Denmark

“…Our results imply that although populationbased self-sampling initiatives are likely to increase general screening coverage (12)(13)(14)(15)(16)(17)(18)(19)(20)(21), certain groups of vulnerable women will still not be screened. Smaller, directly targeted interventions may be needed to increase screening uptake in these groups, such as home visits where self-sampling is offered by community health workers (53,54). Targeted interventions…”