2016
DOI: 10.1158/0008-5472.can-16-0633
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HPV-Related Oropharynx Cancer in the United Kingdom: An Evolution in the Understanding of Disease Etiology

Abstract: Tables: 2 (plus 3 supplemental tables) 4 AbstractA rising incidence of oropharyngeal squamous cell carcinoma (OPSCC) incidence has occurred throughout the developed world, where it has been attributed to an increasing impact of human papillomavirus (HPV) on disease etiology. This report presents the findings of a multicenter crosssectional retrospective study aimed at determining the proportion of HPV-positive and HPV-negative

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Cited by 137 publications
(115 citation statements)
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“…Moreover, the total number of OPSCCs patients also increased from 2000 to 2015. 32 As the number of female OPSCC patients per year was limited, we had to stratify the patients in 5-year intervals; but a significant increase in HPV-attributable OPSCC in female patients could be observed from 2000 till 2015. 13 The increase in HPV-positive OPSCC as well as the general increase in OPSCC corresponds with published data in the United States and other European countries.…”
Section: Discussionmentioning
confidence: 99%
“…Moreover, the total number of OPSCCs patients also increased from 2000 to 2015. 32 As the number of female OPSCC patients per year was limited, we had to stratify the patients in 5-year intervals; but a significant increase in HPV-attributable OPSCC in female patients could be observed from 2000 till 2015. 13 The increase in HPV-positive OPSCC as well as the general increase in OPSCC corresponds with published data in the United States and other European countries.…”
Section: Discussionmentioning
confidence: 99%
“…All are consistent in that in addition to the “classical tonsillar carcinoma” ascribed to heavy alcohol use and smoking, the incidence of HPV-associated tonsillar and base of the tongue carcinomas is alarmingly increasing since the late 1960s. However, recent evidence from the UK indicates that the proportion of OPSCC testing HPV positive between 2002 and 2011 has remained stable (around 50% HPV positive), whereas the incidence of both HPV-negative and HPV-positive OPSCCs is increasing among men but not women [52]. It is well established by now that HPV-positive OPSCCs have a better prognosis.…”
Section: Hpv In Hnsccmentioning
confidence: 99%
“…Currently, good epidemiological data exist for increased numbers of HPV-related oropharyngeal cancer around the world [2,3] (Table 1). While there has been a continued increase in the prevalence of HPV oropharyngeal cancer over time a recent UK study suggests this has plateaued (Table 2).…”
Section: Epidemiology Of Oropharyngeal Cancermentioning
confidence: 99%