HPV prevalence and p16<scp>INK</scp>a overexpression in non‐smoking non‐drinking oral cavity cancer patients

Dediol, Emil; Sabol, Ivan; Virag, Mihajlo; Grce, Magdalena; Müller, Danko; Manojlović, Spomenka

doi:10.1111/odi.12476

Cited by 30 publications

(49 citation statements)

References 47 publications

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“…However, our current findings suggest that patients with HPV 16-associated OCSCC had worse 5-year LR rates following standard treatment compared to those without HPV 16 infections. Consistent with our data, recent studies show that patients with HPV-positive OCSCC had worse survival ( n : 300–1002) than those with HPV-negative OCSCC in India [39], Iran [40], Croatia [41], and Taiwan [5, 9–11, 42]. Consequently, our data should caution against the reliance on radiotherapy alone as a general treatment strategy for patients with HPV-positive OCSCC.…”

Section: Discussionsupporting

confidence: 91%

Molecular and serologic markers of HPV 16 infection are associated with local recurrence in patients with oral cavity squamous cell carcinoma

et al. 2017

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Human papillomavirus (HPV) infections predict mortality in Taiwanese patients with oral cavity squamous cell carcinoma (OCSCC). To address their prognostic significance for local recurrence (LR), in this retrospective cohort study we investigated different serologic and molecular markers of HPV 16 infection in 85 consecutive patients with primary OCSCC who received standard treatment and had their sera stored before treatment. Resected tumor specimens were examined with PCR-based assays for HPV 16 E6/E7 mRNA expression. Sera were tested with suspension arrays for the presence of HPV-specific antibodies using synthetic L1 and E6 peptides as well as a synthetic E7 protein. HPV 16 E6/E7 mRNA, anti-L1, anti-E6, and anti-E7 antibodies tested positive in 12%, 25%, 38%, and 41% of the study patients, respectively. Multivariate analysis identified pathological T3/T4, E6/E7 mRNA, and anti-E7 antibodies as independent risk factors for LR, whereas anti-E6 antibodies were an independent protective factor. In patients with ≥ 3 (high-risk group), 2 (intermediate-risk), and ≤ 1 (low-risk) independent risk factors (predictors), the 5-year LR rates were 75%, 42%, and 4%, respectively. Results were validated in an independent cohort. Together, our preliminary data indicate that HPV 16 infections as well as low and high serum levels of anti-E6 and anti-E7 antibodies, respectively, can serve as biomarkers of LR in patients with OCSCC, whereas the clinical usefulness of anti-HPV 16 antibodies for risk stratification of newly diagnosed cases deserves further scrutiny.

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Section: Discussionsupporting

confidence: 91%

Molecular and serologic markers of HPV 16 infection are associated with local recurrence in patients with oral cavity squamous cell carcinoma

et al. 2017

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“…The degree of cellular deregulations and response to therapy were proven to have bigger influence on improved prognosis in HPV-positive compared to HPV-negative patients. Alcohol consumption was not proven significant in overall and disease-free survival in our study, although some researches indicate that HPV positivity in non-drinking patients is a negative predicting factor [22].…”

Section: Discussioncontrasting

confidence: 77%

Prevalence of human papillomavirus in oropharyngeal squamous cell carcinoma in Serbia

Milovanović¹,

Jotić²,

Andrejic

et al. 2018

Srp Arh Celok Lek

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Introduction/Objective Oropharyngeal carcinoma makes up to 3% of all newly diagnosed carcinomas in the world. In Serbia, oropharyngeal carcinoma constitutes 1.8% of all malignancies. Studies have shown a growing role of infections with human papilloma viruses (HPV) in oropharyngeal cancer etiology. HPVpositive patients have a more favorable prognosis and significantly higher rate of overall survival. The purpose of this paper was to establish how HPV status influenced Serbian patients' overall survival and the disease-free survival according to known risk factors (tobacco and alcohol consummation), clinical TNM stage of the disease, and modality of treatment. Methods The study included 87 patients treated for oropharyngeal carcinoma in a one-year period with a five-year follow-up. Treatment modalities included surgery with or without postoperative radio-or chemoradiotherapy, only radiotherapy or chemoradiotherapy. Sex, common risk factors, TNM stage, and treatment method were considered, as well as the influence of HPV status on the overall survival and the disease-specific survival depending on the presence of risk factors. Results HPV-positive patients with oropharyngeal carcinoma were more frequently men, smokers, and alcohol consumers. Considering clinical T, N, and M stage of the disease, the overall survival and the disease-specific survival rates were better in HPV-positive patients, who had better survival if they were treated with primary surgical therapy rather than primary radiotherapy. Conclusion HPV status significantly influenced survival and locoregional control in Serbian patients with oropharyngeal carcinoma. This implies possible modifications of treatment strategies for these patients in order to further improve their prognosis and treatment outcomes.

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“…However, this notion has yet to be empirically substantiated [7]. Many studies attempted to find biological factors unique to young patients with SCCOT, but distinctive features were not found [11,32,33]. Indeed, SCCOT in young and old patients has not been found to exhibit relevant difference at the molecular level [34].…”

Section: Discussionmentioning

confidence: 99%

Comparison of Squamous Cell Carcinoma of the Tongue between Young and Old Patients

Choi

Song

Choi

et al. 2019

J Pathol Transl Med

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Risk factors for squamous cell carcinoma of the tongue (SC-COT) are well known and include a history of smoking and alcohol consumption. Most incidences occur in older men; 1 however, several reports indicate that the global incidence of SCCOT in young, non-smoking women has been rising, 2-4 a trend also observed in the Korean population. A study by Choi et al. 5 also found that the incidence of SCCOT in younger patients, particularly women, has been increasing. SCCOT in young patients presents with similar clinical outcomes to those for older patients. 6,7 Distinct epidemiological features are apparent for these two cohorts, such as weaker association with smoking and drinking in younger patients, 4,8,9 suggesting that biology and pathogenesis in these groups might also be distinct. This study was designated to compare a set of clinicopathological parameters between sexes (male and female) and age groups (young and old). Young was defined as adults under 45; no standard definition of young regarding SCCOT has been established; however, a cutoff of 45 is frequently used in related studies. 7,10,11 Expression levels of several proteins were also compared through immunohistochemical (IHC) staining. Targeted proteins include p16, p53, mdm2, cyclin D1, glutathione S-transferase P1 (GSTP1), and estrogen receptor (ER), all of which were associated with tumorigenesis of SCCOT in previous studies. 12-17 p16, p53, mdm2, and cyclin D1 are essential to regulation of the cell cycle and apoptosis. Abnormal expression of these proteins in oral squamous cell carcinoma (SCC) has frequently been reported, implying an association with the pathogenesis and prognosis of SC-COT. Some reports have shown that expression levels vary by age groups. 12,15,18-20 GSTP1 is a member of the glutathione S-transferase enzyme superfamily that participates in detoxification processes. Exposure to toxic substances such as tobacco, alcohol, and betel is a major risk factor for SCCOT, 1 and impaired GSTP1 function has been associated with an increased cancer risk. 21 The increasing proportion of women under 45 years old with SCCOT suggests potential involvement with sexual hormone receptors, and increased ER expression in SCCOT has been reported for oral SCC. 13,14 Recent studies found a relationship be

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HPV prevalence and p16INKa overexpression in non‐smoking non‐drinking oral cavity cancer patients

Abstract: NSND are a specific population of OCSCC patients. In contrast to oropharyngeal cancer, HPV and p16 expression in OCSCC are negative predictive factors, especially in NSND patients.

Cited by 30 publications

References 47 publications

Molecular and serologic markers of HPV 16 infection are associated with local recurrence in patients with oral cavity squamous cell carcinoma

Molecular and serologic markers of HPV 16 infection are associated with local recurrence in patients with oral cavity squamous cell carcinoma

Prevalence of human papillomavirus in oropharyngeal squamous cell carcinoma in Serbia

Comparison of Squamous Cell Carcinoma of the Tongue between Young and Old Patients

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