“…Even though E1, E2, L1 and L2 are always encountered in all HPVs, the other genes may vary (Stubenrauch et al, 2007;Nobre et al, 2009). The major oncogenes are considered to be E5, E6 and E7, which are also known for altering a variety of signaling pathways, such as Wnt, Notch, PI3K/Akt, MAPK, IFN and NF-κB and others (Gupta et al, 2018;Xu et al, 2018;Wang and Chen, 2019). However, studies have demonstrated that the HPV infection could alter the interaction between miRNAs and some of these pathways.…”