HPV infection in Brazilian patients with esophageal squamous cell carcinoma: Interpopulational differences, lack of correlation with surrogate markers and clinicopathological parameters

Herbster, Suellen; Ferraro, Cíntia Tereza Lima; Koff, Natália Kirsch; Rossini, Ana; Kruel, Cléber Dario Pinto; Andreollo, Nelson Adami; Rapozo, Davy; Blanco, Tânia Cristina Moita; Faria, Paulo Antônio Silvestre de; Santos, Paulo Thiago de Souza; Albano, Rodolpho Mattos; Simão, Tatiana de Almeida; Pinto, Luís Felipe Ribeiro

doi:10.1016/j.canlet.2012.07.018

Cited by 31 publications

(44 citation statements)

References 39 publications

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“…Among these studies, 6 studies were conducted in China, [23,26,28–30,32] 1 in Japan, [31] 1 in Sweden, [24] 1 in Australia, [25] and 1 in Brazil. [27] Of all the selected studies, 3 presented HRs, [25,26,28] whereas in the other 7 studies, [23,24,27,29–32] HRs were absent, and we needed to calculate the HR s from the survival curves. One study [25] did not give accurate data for follow-up.…”

Section: Resultsmentioning

confidence: 99%

Human papillomavirus-related esophageal cancer survival

et al. 2016

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Section: Resultsmentioning

confidence: 99%

Human papillomavirus-related esophageal cancer survival

et al. 2016

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“…Recent meta-analyses have not evaluated p16 overexpression to characterize the potential aetiological role of HPV infection in ESCC. Studies examining both p16 overexpression and HPV positivity in ESCC have reported a low rate of double-positive ESCC lesions, approximately 5% of all cases[64-71]. The available data are markedly different from oropharyngeal and cervical cancer data, and the association between p16 and HPV in ESCC therefore remains limited.…”

Section: Hpv and Esophageal Cancermentioning

confidence: 99%

Human papillomavirus and gastrointestinal cancer: A review

Bucchi¹,

Stracci²,

Buonora³

et al. 2016

WJG

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Human papillomavirus (HPV) is one of the most common sexually transmitted infections worldwide. Exposure to HPV is very common, and an estimated 65%-100% of sexually active adults are exposed to HPV in their lifetime. The majority of HPV infections are asymptomatic, but there is a 10% chance that individuals will develop a persistent infection and have an increased risk of developing a carcinoma. The International Agency for Research on Cancer has found that the following cancer sites have a strong causal relationship with HPV: cervix uteri, penis, vulva, vagina, anus and oropharynx, including the base of the tongue and the tonsils. However, studies of the aetiological role of HPV in colorectal and esophageal malignancies have conflicting results. The aim of this review was to organize recent evidence and issues about the association between HPV infection and gastrointestinal tumours with a focus on esophageal, colorectal and anal cancers. The ultimate goal was to highlight possible implications for prognosis and prevention.

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“…Antunes et al [28] and Herbster et al [38] from Brazil as well as Koh et al [39] from the Korean Cancer Centre Hospital found that tests for HPV DNA were negative in all their samples. Lofdahl et al [40] set up a population-based study relating HPV infection to tumor site in patients diagnosed with ESCC in Stockholm County in Sweden in 1999-2006.…”

Section: Evidence Of a Negative Association Between Hpv And Esccmentioning

confidence: 95%

Viruses, Other Pathogenic Microorganisms and Esophageal Cancer

Liu

Bao

et al. 2015

Gastrointest Tumors

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Background: Esophageal cancer (EC) is the eighth most prevalent malignant tumor and the sixth leading cause of cancer mortality throughout the world. Despite the technical developments in diagnosis and treatment, the 5-year survival rate is still low. The etiology of EC remains poorly understood; multiple risk factors may be involved and account for the great variation in EC incidence in different geographic regions. Summary: Infection with carcinogenetic pathogens has been proposed as a risk factor for EC. This review explores the recent studies on the association of human papillomavirus (HPV), Epstein-Barr virus (EBV), Helicobacter pylori and esophageal bacterial biota with EC. Key Message: Among the above-mentioned pathogens, HPV most likely contributes to esophageal squamous cell carcinoma (ESCC) in high-risk populations. New techniques are being applied to studies on the role of infection in EC, which will inevitably bring novel ideas to the field in the near future. Practical Implications: Multiple meta-analyses support the finding of a higher HPV detection rate in regions associated with high risk for ESCC compared to low-risk areas. A potential role of HPV in the rise of esophageal adenocarcinoma (EAC) was proposed recently. However, further studies are required before a firm conclusion can be drawn. Less work has been done in studying the association between EBV and ESCC, and the results are quite controversial. H. pylori infection is found to be inversely related to EC, which is probably due to the reduced incidence of gastroesophageal reflux disease. Analysis of the esophageal bacterial biota revealed distinct clusters of bacteria in normal and diseased esophagi. A type II microbiome rich in Gram-negative bacteria potentially contributes to EAC by inducing chronic inflammation. Novel findings from such studies as these may benefit public health by justifying anti-infection measures to prevent EC.

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HPV infection in Brazilian patients with esophageal squamous cell carcinoma: Interpopulational differences, lack of correlation with surrogate markers and clinicopathological parameters

Cited by 31 publications

References 39 publications

Human papillomavirus-related esophageal cancer survival

Human papillomavirus-related esophageal cancer survival

Human papillomavirus and gastrointestinal cancer: A review

Viruses, Other Pathogenic Microorganisms and Esophageal Cancer

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