HPV infection, anal intra-epithelial neoplasia (AIN) and anal cancer: current issues

Stanley, Margaret; Winder, David M.; Sterling, Jane; Goon, Peter

doi:10.1186/1471-2407-12-398

Cited by 84 publications

(69 citation statements)

References 28 publications

(32 reference statements)

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“…Stanley et al (2012) affirmed that immunocompromised patients presented SILs with higher risk of progression and evolution to cancer in comparison with immunocompetent patients.…”

Section: Discussionmentioning

confidence: 72%

HPV infection-associated anogenital cyto-colpo-histological findings and molecular typing in HIV-positive women

et al. 2015

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ABSTRACT. HIV and human papillomavirus (HPV) coinfection is increasing, especially in the anal canal (AC) and cervico-vaginal regions.We identified anal epithelium abnormalities related to high-risk HPV (HR-HPV) lesions in the lower genital tracts (LGTs) of HIV-positive women, described the HPV genotypes identified, and assessed the expression of E6/E7 oncogenes in coinfected patients. Ninety-eight women were enrolled in groups combining HIV status and presence or absence of HPV in the LGT. Anal and cervical smears were collected for cytology and HR-HPV assays using Cobas ® and/ or PapilloCheck ® . Samples with highly oncogenic HPV genotypes were confirmed by NucliSENS EasyQ ® . Forty-two HIV-positive (25-52; mean age 39.5) and 56 HIV-negative (18-58; mean age 35.7) patients were included. E2 and C1 groups presented AC alterations (P = 0.002); altered images HPV-associated anogenital cytology in HIV-positive women for high-resolution anoscopy were higher in E1 and C2 (P < 0.001). Of the 29 women with alterations, 41.38% were HIV-negative and 58.62% were HIV-positive (P < 0.001). HIV-positive patients accounted for 29% of the anal high-grade squamous intraepithelial lesions (P = 0.015). The Cobas ® positive result frequency was higher in three AC groups than in the other groups. There was variation in the number of HPV types in the cervicovaginal samples among the study groups (P < 0.001). Anal cytology and anoscopy showed more altered findings in HIV-positive patients with HPV in the LGT. HR-HPV anal infections by various genotypes are common and are associated with cervical infections in HIV-positive patients. E6/E7 expression is apparently more common in the AC of HIV-positive women.

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“…Stanley et al (2012) affirmed that immunocompromised patients presented SILs with higher risk of progression and evolution to cancer in comparison with immunocompetent patients.…”

Section: Discussionmentioning

confidence: 72%

HPV infection-associated anogenital cyto-colpo-histological findings and molecular typing in HIV-positive women

et al. 2015

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“…Some subtypes can also be detected in pre-invasive changes cervical intraepithelial neoplasia (CIN), AIN, or VIN [4].…”

Section: Discussionmentioning

confidence: 99%

Four cancers related to HPV 16 infection in a 34-year-old woman

Kędzierawski¹,

Kopczyński²,

Misiek³

et al. 2017

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Human papilloma viruses are widespread among people. Two hundred subtypes of these viruses have been described. Most of the infections are not clinically relevant. Long-term infection by some high sub-type of human papilloma virus, however, can lead to pre-invasive and invasive cancers of urogenital organs, head and neck region, and skin. The paper presents the case of 34-year-old woman in whom four cancers associated with infection with human papilloma virus subtype 16 were diagnosed. The patient was treated with surgery and radiotherapy for cancers of the vulva, the perianal area, fingers, and cervix. This paper describes the course and outcome of the treatment. StreszczenieWirusy brodawczaka ludzkiego są rozpowszechnione wśród ludzi. Opisano ok. 200 podtypów tych wirusów. Większość infekcji wirusem brodawczaka ludzkiego nie ma klinicznego znaczenia, jednak przy długotrwałej infekcji podtypem wysokiego ryzyka wirus ten może powodować raka przedinwazyjnego i inwazyjnego układu moczowo-płciowego, regionu głowy i szyi oraz skóry. W pracy przedstawiono przypadek 34-letniej kobiety, u której zdiagnozowano cztery ogniska raka związanego z infekcją wirusem brodawczaka ludzkiego podtypu 16. Pacjentka była poddana leczeniu skojarzonemu -chirurgii i radioterapii, z powodu raka sromu, skóry okolicy okołoodbytowej, palców i szyjki macicy. W artykule opisano przeprowadzone leczenie i jego wyniki.

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“…HPV diğer papilloma virüsler gibi sadece deri veya mukozal membranların keratinositlerinde etkili enfeksiyonlar oluşturur (4,5). Literatürde tanımlanan 170'ten fazla tipi olup bunlardan 40 kadarı tipik olarak cinsel temasla geçiş gösterir ve anorektal bölgede enfeksiyonlar oluşturur.…”

Section: İnsan Papilloma Virüs Enfeksiyonuunclassified