HPV-DNA, vascular space invasion, and their impact on the clinical outcome in early-stage cervical carcinomas

Abstract

The present study was designed to analyze the relationship of human papillomavirus (HPV)-DNA, microvessel density, and their impact on clinical outcome in early cervical carcinoma. HPV-DNA was evaluated in 171 cases of cervical carcinoma treated from 1965 to 1990. In 110 cases, the analyses could be performed. A polymerase chain reaction technique was used on paraffin-embedded specimens obtained before the start of therapy. HPV-DNA of any type was detected in 78% (86/110) of all evaluable tumors. HPV16 was the predominant type and was detected in 56% (62/110), HPV18 in 8% (9/110), and HPV35 in 21% (23/110). Patients with tumors containing HPV16 or HPV18 were significantly (P = 0.011) younger than patients with tumors not containing either of these two subtypes. Vascular space invasion and lymph node metastases were observed more frequently in tumors expressing HPV16 and HPV18 (P = 0.002, P = 0.047) than in tumors negative for these HPV strains. Tumors containing HPV16 and HPV18 were significantly (P = 0.012) larger and more frequently (P = 0.005) associated with higher FIGO stages. The cancer-specific survival rate was lower for patients with HPV16- and HPV18-positive tumors, but the difference was not statistically significant. The microvessel density was a non-significant prognostic factor. The overall 5-year survival rate of the complete series was 91%. It was concluded that HPV-DNA was a prognostic factor in early-stage cervical cancer and was associated with the age of the patient, vascular space invasion, lymph node metastases, tumor size, and FIGO stage.

Clinical Effect of Human Papillomavirus Genotypes in Patients With Cervical Cancer Undergoing Primary Radiotherapy

“…In accordance with the results from other groups, patients with HPV-negative tumors tended to have a worse survival rate (9,18,(21)(22)(23), although a contradictory result was suggested by Pilch et al (20). Recently, HPV infection has also been associated with improved outcomes in patients with squamous cell carcinoma of the head and neck, especially of the oropharynx (24).…”

Supraclavicular lymph node metastases of unknown origin: HPV-typing identifies the primary tumour

“…HPV-infection therefore represents the most important risk factor for the development of CC (Walboomers et al 1999;Graflund et al 2004a;Santin et al 2005). HPV-infection therefore represents the most important risk factor for the development of CC (Walboomers et al 1999;Graflund et al 2004a;Santin et al 2005).…”

“…HPV-infection therefore represents the most important risk factor for the development of CC (Walboomers et al 1999;Graflund et al 2004a;Santin et al 2005). Although these high-risk HPV-types are associated with cervical dysplasia, only a small percentage of infected women develop invasive cancer (Graflund et al 2004a;Hernadi et al 2005). HPV-types 16 and 18 are the most prevalent types (HPV16: 44-84%; HPV18: 2-39%) detected in these patients (Graflund et al 2004a;Santin et al 2005;Scholten et al 2005;Valdespino et al 2005).…”

“…Their incidence ranges 0.5-10% of all cancers (Milovic et al 2002;Joshi et al 2004;Park et al 2005;Polyzoidis et al 2005). Squamous cell carcinomas (SCC) are a less frequent subtype involving mainly the cervical nodes (Graflund et al 2004a). The majority of cases are adenocarcinoma.…”

Fascin in Gynecological Cancers: An Update of the Literature

“…FSCN1 was also reported to be associated with high-risk HPV to enhance cancer progression. It is well-known that high-risk HPVs are major players in the onset and progression of cervical cancer and correlate with lymph node and vascular invasion and the tumor size [ 120 , 121 ]. More specifically, Yasmeen et al [ 122 ] investigated the expression of oncogenes, including FSCN1 , in cervical cancer.…”