HPV DNA Testing of Self-collected Vaginal Samples Compared With Cytologic Screening to Detect Cervical Cancer

Wright, Thomas; Denny, Lynette; Kuhn, Louise; Pollack, Amy E.; Lörincz, Attila T.

doi:10.1001/jama.283.1.81

Cited by 394 publications

(211 citation statements)

References 21 publications

(16 reference statements)

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“…Several studies have recently reported the possible use of SC vaginal samples for HPV DNA testing [17,18,19]. Dzuba et al [22] indicated that inherently private self-sampling for the HPV test was more acceptable in younger, wealthier and more educated women than the conventional Pap test.…”

Section: Discussionmentioning

confidence: 99%

“…Dzuba et al [22] indicated that inherently private self-sampling for the HPV test was more acceptable in younger, wealthier and more educated women than the conventional Pap test. Although some studies reported that the sensitivity for detection of high-grade CIN in cytological specimens obtained from SC vaginal material was lower than that of conventional cytology, studies have shown that SC cervicovaginal specimens are highly representative of the high-risk HPV DNA status of the cervix [18,19,36,37,38]. A previous study using swabs as the SC device and a more sensitive PCR-based DNA detection method of high-risk HPV testing found SC cervicovaginal samples to be as reliable as physician-taken samples [39,40].…”

Section: Discussionmentioning

confidence: 99%

“…Some studies have reported that SC samples were suitable for HPV-DNA testing [17,18,19]. Moreover, some studies have shown that the sensitivity of HPV-DNA tests for the detection of high-grade intraepithelial lesions and invasive carcinoma was superior to that of Pap tests [5,20,21].…”

Section: Introductionmentioning

confidence: 99%

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Comparison of Self-Collected and Clinician-Collected Materials for Cervical Cytology and Human Papillomavirus Genotyping: Analysis by Linear Array Assay

et al. 2010

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Objective: This study compared the usefulness of self-collected (SC) and clinician-collected (CC) materials for cervical cytology and human papillomavirus (HPV) genotyping. Study Design: Fifty women with previous positive cytology and who were undergoing regular checkups were included in the study. CC samples were collected using a Cervex-Brush Combi with liquid-based cytology. One month later, SC material was acquired using the Rovers Viba-brush vaginal sampler, and fixed at home. Thin-layer specimens were prepared from both samples and HPV status was analyzed using a linear array. Results: A total of 37/50 CC (74%) and 41/50 SC (82%) cases were positive for HPV. Pap tests identified high-grade squamous intraepithelial lesions in 11 (22%) and seven (14%) patients, low-grade squamous intraepithelial lesions in 19 (38%) and 16 (32%), atypical squamous cells of undetermined significance in 2 (4%) and 0 patients, and NILM (negative for intraepithelial lesion or malignancy) in 18 (36%) and 27 (54%) patients in the CC and SC groups, respectively. Conclusions: SC material had a lower positive cytology rate, but a higher HPV-positive rate than CC material. These results suggest that a combination of Pap and HPV tests on SC material may provide a diagnostic strategy with high sensitivity and specificity.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Comparison of Self-Collected and Clinician-Collected Materials for Cervical Cytology and Human Papillomavirus Genotyping: Analysis by Linear Array Assay

et al. 2010

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“…Thus, many HIV-infected patients are not screened for anal cancer although they are at-risk individuals [2,5]. In the setting of cervical cancer screening, self-sampling techniques for the purpose of cervical cytology and HPV testing have been proposed as an appropriate and effective alternative to sampling performed by clinicians [14]. To date, only 3 studies have assessed anal self-sampling in HIV-positive and -negative MSM and in HIV-negative women [15,16,17], and 1 study has assessed feasibility, acceptability, and accuracy of anal self-sampling [18].…”

Section: Introductionmentioning

confidence: 99%

Feasibility and Acceptability of Anal Self-Sampling for Human Papillomavirus Screening in HIV-Infected Patients

et al. 2016

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Objectives: Anal cancer incidence is increasing among HIV-positive patients. No consensus currently exists for the screening of anal dysplasia. This study aimed at evaluating the feasibility and acceptability of anal self-sampling and assessing the prevalence of human papillomavirus (HPV) types among HIV-positive patients from Marseille University Hospitals. Methods: Between October 2013 and March 2014, during their regular visits for the monitoring of their HIV infection in an HIV outpatient clinical unit of Marseille University Hospitals, patients were asked to self-sample anal swabs for HPV detection. A specimen self-collection kit was provided. HPV detection and genotyping were performed using in-house protocols. The quality of self-sampling was assessed by concurrent cellular quantification in collected samples. Results: The acceptability rate of anal self-sampling was 91%, and 91% of the self-sampled specimens were appropriate for HPV screening. In addition, 76% of the samples were positive for HPV, including 54% of HPV types with oncogenic potential. Conclusions: This study indicates that HPV detection and typing through anal self-sampling is a valuable strategy to screen patients at high risk for anal cancer development. This could allow earlier management of anal lesions and related cancer in patients at high risk for HPV.

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“…The results of these studies were similar. The sampling devices demonstrated a comparable sensitivity and a lower specificity when they were compared to conventional cytology, and these results were mainly due to the prevalence of nonpersistent HPV infections in young women [7,8,9]. …”

Section: Introductionmentioning

confidence: 99%

Assessment of the Fournier® Cervical Specimen Self-Sampling Device Using the Papanicolaou Method

Rocha

Meurer

et al. 2012

Acta Cytologica

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Introduction: Communities of socially excluded immigrant women, especially Muslim, Asian, Aboriginal and Maroon, are among the groups of women with low rates of cervical screening. Exclusion of the pelvic examination could result in a higher acceptance of the cervical screening among these communities and an increase in screening coverage. Aim: To assess the performance of the Fournier® cervical specimen self-sampling device for the cytological diagnosis of precursor or neoplastic lesions in the uterine cervix using the Papanicolaou method. Methods: A case-control study was conducted at the Cervical Pathology Outpatient Clinic. Liquid-based cytology slides were obtained by the Fournier device and stained using the Papanicolaou method. The slides were analyzed by two pathologists, blinded for the colposcopic and histological results and compared to Papanicolaou smears that were obtained using the traditional method of speculum examination. Results: There were 68 patients who were considered free from precursor or neoplastic cervical lesions. There were 35 cases of low-grade lesions, 13 cases of high-grade lesions and 3 cases of squamous-cell carcinoma. According to the first and second pathologists, the sensitivities of the device for identifying precursor or neoplastic cervical lesions were 50.0 and 60.0%, and the specificities of the method were 81.8 and 73.8%. According to the first and second pathologists, the positive predictive values of the diagnostic test were 0.67 and 0.63, and the negative predictive values were 0.68 and 0.71, respectively. Conclusion: Sensitivity and specificity of the Fournier device test was comparable to Papanicolaou smears tests obtained using the traditional method with speculum examination.

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HPV DNA Testing of Self-collected Vaginal Samples Compared With Cytologic Screening to Detect Cervical Cancer

Cited by 394 publications

References 21 publications

Comparison of Self-Collected and Clinician-Collected Materials for Cervical Cytology and Human Papillomavirus Genotyping: Analysis by Linear Array Assay

Comparison of Self-Collected and Clinician-Collected Materials for Cervical Cytology and Human Papillomavirus Genotyping: Analysis by Linear Array Assay

Feasibility and Acceptability of Anal Self-Sampling for Human Papillomavirus Screening in HIV-Infected Patients

Assessment of the Fournier® Cervical Specimen Self-Sampling Device Using the Papanicolaou Method

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