HPV DNA in plasma of patients with cervical carcinoma

Sathish, Narayanan; Abraham, Priya; Peedicayil, Abraham; Sridharan, Gopalan; John, Subhashini; Shaji, R. V.; Chandy, George

doi:10.1016/j.jcv.2004.03.013

Cited by 57 publications

(63 citation statements)

References 28 publications

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“…HPV has long been thought not to have a viraemic phase in humans, although more recent data suggests that it my not be so (12,13). In lung cancer, Chiou et al raised the possibility of viraemic spread when they described a 70% concordance rate between HPV DNA in peripheral blood and paired lung cancer tissue (14).…”

Section: Discussionmentioning

confidence: 99%

Assessment of human papillomavirus and Epstein-Barr virus in lung adenocarcinoma

Lim

2009

Oncol Rep

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Abstract. The association of human papillomavirus (HPV) and Epstein-Barr virus (EBV) infection with non-small cell lung cancer is controversial. HPV and EBV prevalence in a uniform population of lung adenocarcinoma was investigated, hypothesizing that there would be differences seen between smokers and non-smokers and between sexes. Patients involved in this study were selected from a single institution database of lung cancer. In total 497 patients with adenocarcinoma were identified and 110 patients had sufficient tissue for analysis with an in situ hybridization method that probed for high-risk and low-risk HPV and EBV. There were 65 males and 45 females, 78 patients with stage I-IIIA disease and 32 patients with stage IIIB-IV disease. There were similar number of smokers and non-smokers. Across all stages HPV and EBV staining was absent from all tissues examined. It is unlikely that HPV or EBV is an important etiological agent in adenocarcinoma of the lung, even among the neversmokers. IntroductionCigarette smoke is strongly associated with the development of lung cancer (1). While the epidemic of smoking has reduced through public health awareness programs and education, the incidence of lung cancer remains unabated. There has been a demographic change in the global pandemic with a global realignment of histological subtypes. Adenocarcinoma incidence is rising globally among both smokers and nonsmokers. Up to 30% of all diagnosed non-small cell lung cancer (NSCLC) among various Asian countries, including Singapore, do not have a history of exposure to cigarette smoking. These patients tend to be predominantly female and have adenocarcinoma (2). This has given rise to different postulates as to the possible etiologies of NSCLC in this distinct of patients, ranging from exposure to cooking oil fumes (3,4), as well as diet and cancer susceptibility genotypes among Asians (5-7). Human papillomavirus (HPV) and Epstein-Barr virus (EBV) have been variously described to be associated and causative with several cancers. HPV is likely to be causal in cervical carcinoma and head and neck squamous cell carcinoma (HNSCC), and EBV in nasopharyngeal carcinoma. There have been various reports of association between HPV and EBV with lung cancer but results have not been conclusive (8). Leveraging on the excess of non-tobacco related lung cancer in our patients we investigated HPV and EBV prevalence in a uniform population of adenocarcinoma of the lung, hypothesizing that there would be differences seen between smokers and nonsmokers and between sexes. Patients and methodsPatients. Patients involved in this study were selected from a database of NSCLC patients, diagnosed in a single institution (SGH) from 1999 to 2002. The study had the approval of the Institutional Review Board of National Cancer Centre Singapore. The main selection criterion was a diagnosis of adenocarcinoma. Four hundred and ninety-seven patients were identified and among them, 110 patients had sufficient tissue blocks available for our analysis using in ...

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Section: Discussionmentioning

confidence: 99%

Assessment of human papillomavirus and Epstein-Barr virus in lung adenocarcinoma

Lim

2009

Oncol Rep

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“…There aren't any reports as how the virus is able to infect other organs; two mechanisms though, have been proposed: a mechanical path where the virus is scrubbed through the skin [25], and a systemic path where HPV spreads through the bloodstream by organ perfusion [36]. Whether any or both mechanisms are responsible for HPV propagation is not clear, HPV DNA has been found in plasma of patients with diagnosis of cervical cancer [37][38][39][40], and in sera of patients with breast cancer [24] and with HPV-associated head and neck squamous cell carcinoma [41]. Another reason for the few positive detected is the differential selective advantage given to the neoplastic cells by HPV and the relative number of infected cells within the clone pool.…”

Section: Discussionmentioning

confidence: 99%

Low frequency of human papillomavirus DNA in breast cancer tissue

Mendizabal-Ruiz

Morales

Ramírez-Jirano

et al. 2008

Breast Cancer Res Treat

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Human papillomavirus (HPV) is considered the aetiological agent for cervical cancer. Several reports have addressed a relationship with HPV and breast cancer, as different HPVs have been identified. The purpose of this study was to detect HPV DNA in 67 breast cancer patients and 40 non-malignant disease breast tissues by means of Polymerase Chain Reaction with consensus primers. The frequency of HPV in the cases group were 4.4% (3/67) and no positive samples among the reference group were identified. From the 3 positive samples, HPV types 16, 18 and 33 were identified by restriction patterns and direct sequencing. The high diversity among detection in the related studies shows that population genomic heterogeneity plays an important role in the disease. The low frequency detected in the present study suggests that HPV does not play an important role in breast cancer.

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“…The perinatal infection of the newborn babies has been recognised first in the case of papillomaviruses [27,38,164,165,174], herpesviruses [12,50,70,112,143,152,196,197], TT virus [29], hepatitis B virus (HBV), HIV and hepatitis C virus (HCV) [112,117,147,169] during delivery. Molecular characterisation of viruses in sexual partners [196] and that in the parents and neonates [102,165,183,196,197] supported perinatal transmission, too.…”

Section: The Perinatal Transmission and Transplacental Transfer Of VImentioning

confidence: 99%

Heterogeneous Pathways of Maternal-fetal Transmission of Human Viruses (Review)

Younes

Csire

Kapusinszky

et al. 2009

Pathol. Oncol. Res.

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Several viruses can pass the maternal-fetal barrier, and cause diseases of the fetus or the newborn. Recently, however, it became obvious, that viruses may invade fetal cells and organs through different routes without acute consequences. Spermatozoa, seminal fluid and lymphocytes in the sperm may transfer viruses into the human zygotes. Viruses were shown to be integrated into human chromosomes and transferred into fetal tissues. The regular maternal-fetal transport of maternal cells has also been discovered. This transport might implicate that lymphotropic viruses can be released into the fetal organs following cellular invasion. It has been shown that many viruses may replicate in human trophoblasts and syncytiotrophoblast cells thus passing the barrier of the maternal-fetal interface. The transport of viral immunocomplexes had also been suggested, and the possibility has been put forward that even anti-idiotypes mimicking viral epitopes might be transferred by natural mechanisms into the fetal plasma, in spite of the selective mechanisms of apical to basolateral transcytosis in syncytiotrophoblast and basolateral to apical transcytosis in fetal capillary endothelium. The mechanisms of maternal-fetal transcytosis seem to be different of those observed in differentiated cells and tissue cultures. Membrane fusion and lipid rafts of high cholesterol content are probably the main requirements of fetal transcytosis. The long term presence of viruses in fetal tissues and their interactions with the fetal immune system might result in post partum consequences as far as increased risk of the development of malignancies and chronic pathologic conditions are discussed.

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HPV DNA in plasma of patients with cervical carcinoma

Cited by 57 publications

References 28 publications

Assessment of human papillomavirus and Epstein-Barr virus in lung adenocarcinoma

Assessment of human papillomavirus and Epstein-Barr virus in lung adenocarcinoma

Low frequency of human papillomavirus DNA in breast cancer tissue

Heterogeneous Pathways of Maternal-fetal Transmission of Human Viruses (Review)

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