HPV Detection and p53 Alteration in Squamous Cell Verrucous Malignancies of the Lower Genital Tract

Pilotti, Silvana; Donghi, R.; D'Amato, Lucia; Giarola, Monica; Longoni, Alberto; Torre, Gabriella Della; Palo, Giuseppe De; Rilke, F

doi:10.1097/00019606-199300020-00036

Cited by 26 publications

(17 citation statements)

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“…39 By further supporting this hypothesis, altered p53 expression was found in 2 Buschke-Lowenstein tumors associated with SCC. 47 The histologic appearance ( Fig. 2) of VC may be surprisingly benign.…”

Section: Epidermodysplasia Verruciformismentioning

confidence: 99%

Viral-Associated Nonmelanoma Skin Cancers: A Review

Dubina¹,

Goldenberg²

2009

The American Journal of Dermatopathology

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Nonmelanoma skin cancers are the most common malignancies in the United States, with over 1.3 million patients diagnosed yearly. Several types of nonmelanoma skin cancer and precancerous lesions have an associated viral pathogenesis, including epidermodysplasia verruciformis, verrucous carcinoma, bowenoid papulosis, Kaposi sarcoma, squamous cell carcinoma, and, most recently, Merkel cell carcinoma. It is now widely accepted that high-risk human papillomaviruses (HPVs) play a key role in pathogenesis of cervical and anogenital cancer. Currently, 108 types of HPV have been discovered. They can be divided into genera including alpha, beta, and gamma HPVs, which comprise the majority of cutaneous HPVs. The relationship between viruses and cancer is a popular focus of research in an era of AIDS and organ transplantation, where immunosuppression is not uncommon. The incidence of viral-related malignancies in these populations is increasing. Because of the widespread nature of these cutaneous malignancies, an evaluation of these conditions is valuable. This review of the literature will focus on the histologic aspects of viral-associated skin malignancies, as well as the epidemiology, etiology, and clinical aspects of these diseases.

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Section: Epidermodysplasia Verruciformismentioning

confidence: 99%

Viral-Associated Nonmelanoma Skin Cancers: A Review

Dubina¹,

Goldenberg²

2009

The American Journal of Dermatopathology

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“…Enhancement of the oncogenic properties of these low-risk viruses by genomic alterations has also been suggested on the basis of several observations (rearrangements of the noncoding region in DNA sequences, subtle aminoacid changes in the HPV 6 E7 protein, etc.). [185][186][187][188] A p53 tumor suppressor gene mutation may be the critical biologic event in the shifting of this low-risk HPV-related neoplasm to its locally aggressive behavior, 189 although this hypothesis is still controversial 190 and deserves further evaluation. Altered p53 expression has been demonstrated in 2 tumors associated with invasive SCC (1 positive for HPV 6, the other for HPV 11).…”

Section: Lack Of Circumcision and Related Factorsmentioning

confidence: 99%

“…Altered p53 expression has been demonstrated in 2 tumors associated with invasive SCC (1 positive for HPV 6, the other for HPV 11). 189 Penile lichen sclerosus. Penile lichen sclerosus (balanitis xerotica obliterans) is a chronic sclerosing inflammatory disorder of unknown cause that may lead in some cases to meatal stenosis or acquired phimosis (Fig 1).…”

Section: Lack Of Circumcision and Related Factorsmentioning

confidence: 99%

Penile cancer

Micali

Nasca

Innocenzi

et al. 2006

Journal of the American Academy of Dermatology

116

118

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“…However, the E6 ⁄ E7 oncoproteins or p53 tumour suppressor gene mutation may be critical in the HPV-associated transition of BLT to frank carcinoma. 7 The true incidence of these HPV types is difficult to estimate in BLT as only multiple case reports have been published. It would seem, however, that almost all cases of BLT are associated with HPV 6 and 11 with only isolated reports of an association with HPV 16 and 18.…”

Section: Reportmentioning

confidence: 99%

Giant condyloma of Buschke-Loewenstein in association with erythroderma

Antony

Ardern‐Jones²,

Evans³

et al. 2003

Clinical and Experimental Dermatology

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The Buschke-Loewenstein tumour is regarded as a type of verrucous carcinoma occurring on anogenital mucosal surfaces. The tumour is locally invasive but displays a benign cytology and rarely metastasizes. It is associated with human papillomavirus types 6 and 11. We describe a case of Buschke-Loewenstein tumour occurring in a 61-year-old man which behaved in a locally aggressive manner and was associated with human papillomavirus type 16 and erythroderma which proved resistant to treatment. The patient refused surgery and therapy with interferon alpha was ineffective. Chemotherapy with systemic cisplatin and 5-fluorouracil produced a partial response before the patient succumbed from gram-negative septicaemia.

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HPV Detection and p53 Alteration in Squamous Cell Verrucous Malignancies of the Lower Genital Tract

Cited by 26 publications

References 0 publications

Viral-Associated Nonmelanoma Skin Cancers: A Review

Viral-Associated Nonmelanoma Skin Cancers: A Review

Penile cancer

Giant condyloma of Buschke-Loewenstein in association with erythroderma

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