HPV and other risk factors of oral cavity/oropharyngeal cancer in the Czech Republic

Abstract

The difference in the prevalence of HPV DNA positive tumours between cases of oral cavity and oropharyngeal carcinoma exposed and not exposed to tobacco or alcohol support the theory that HPV DNA positive tumours form an aetiologically distinct subgroup of head and neck tumours.

Human Papillomavirus as an Independent Predictor in Oral Squamous Cell Cancer

“…Tumors with HPV infection tended to be associated with a decreased exposure to tobacco (OR=56.0, 95% CI: 10.2-308.5). Our result is in consensus with some other investigations which considered smoking as a protective effect on HPV status in the oral cavity (Ritchie et al, 2003;Tachezy et al, 2005). It has been suggested (Ritchie et al, 2003) that smoking could increase the keratinization of oral mucosal which may make the mucosa more resistant to minor trauma, a proposed mechanism for the necessary infection of the basal layer cells by HPVs.…”

“…Previous studies have noticed that patients with HPV-positive tumors are less likely to have p53 mutations. The absence of p53 mutations in the tumor cell may allow an enhanced response to radiotherapy (Tachezy et al, 2005;Hoffmann et al, 2005). Hafkamp et al suggested that radiotherapy may decrease the ability of HPV-E6 and E7 to interact with p53 and pRb which supported the hypothesis above (Hafkamp et al, 2004).…”

P16 Expression in Laryngeal Squamous Cell Carcinoma and its Relationship with Human Papillomavirus

“…50,61 HPV-negatif tümörlere göre HPV-pozitif tümörlerde sigara ve alkol tüketimi daha azdır. 30,58,62 Radyoterapiye cevap daha iyidir. 49,60,[63][64][65] Lindel ve ark.…”

Individualizing therapy for oropharyngeal cancer patients

“…Human papillomavirus-positive oropharyngeal carcinoma patients are more likely to have early tumor and nodal stage, better performance status, younger age, female gender and to consume fewer cigarettes and less alcohol [19].…”