HPV-11- and HPV-16-Associated Oral Verrucous Carcinoma

Abstract

Background: Verrucous carcinoma is a slowly growing, well-differentiated neoplasm with a predilection for the oral cavity. Objective: Data on the association of human papillomavirus (HPV) with oral verrucous carcinoma are very scarce. We searched for the presence of HPV in different stages of the tumour in a patient repeatedly treated by means of surgery, cryotherapy, radiotherapy and chemotherapy over a decade. Methods: HPV DNA was detected in archival tumour tissue by nested PCR. HPV types were identified based on restriction fragment analysis. Results: HPV type 11 was found in 1 early-stage and HPV 16 in 2 late-stage biopsy specimens of the tumour. Conclusion: Our findings provide further evidence for a role of HPV in oral verrucous carcinoma. The case history emphasizes the importance of a joint clinicopathological approach to this tumour.

Carcinoma verrucoso: uma variante clínico-histopatológica do carcinoma espinocelular

“…2 , 3 The expression verrucous carcinoma was defined by L . V. A c k e r m a n 4 5 V C is a S C C with a low degree of dysplasia, and low incidence. 6 Its biological aggressiveness is…”

“…Ackerman 4 em 1948, para caracterizar uma neoplasia verrucosa, bem diferenciada, de lento crescimento e sem tendência a metastatizar. 5 O CV é um CEC com baixo grau de displasia, de incidência infreqüente. 6 A agressividade 8 It may be localized on the skin and in the mucosas.…”

“…7 The oral cavity is the V C site par excellence, being re s p o n s ible for 70% of cases. 5 Oral V C is responsible for a pro p o rtion of oral S C Cs varying from 4.5-to-9.5%. 5 It pre d o m i n a t e s in men over the age of 65 years.…”

“…5 Oral V C is responsible for a pro p o rtion of oral S C Cs varying from 4.5-to-9.5%. 5 It pre d o m i n a t e s in men over the age of 65 years. 6 It is clinically characterized by papules or a notably verrucous, white-grey plaque, with slow growth.…”

“…2,5,6 A case has been described oral lichen planus in association with VC. 6 biológica é limitada ao local, sendo um tumor de crescimento predominante horizontal, e com maior tendência para erodir do que infiltrar.…”