HPTLC-Densitometric Method for Simultaneous Estimation of Olmesartan medoxomil and Chlorthalidone in Tablet Dosage Form

Vyas, Amitkumar J.; Gol, Dhruvanshi A.; Usdad, Riddhi G.; Patel, Ashok B.; Patel, Nilesh K.; Chudasama, Alpesh

doi:10.1080/22297928.2020.1814859

Cited by 3 publications

(1 citation statement)

References 14 publications

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“…Validation of the method was carried out as per International Conference on Harmonization (ICH) guideline Q2 (R1). The HPTLC densitometric-driven way is highly suitable for analyzing Olmesartan medoxomil and Chlorthalidone in dosage form without interference [31].…”

Section: High-performance Thin-layer Chromatography (Hptlc)mentioning

confidence: 99%

Review of Determination of Chlortalidone Levels in Pharmaceutical Preparations and Biological Matrix

Fitrizal¹,

Misfadhila²,

Rivai³

2021

IJPSM

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Chlortalidone is a compound that is often used in the pharmaceutical world as an oral drug to treat hypertension. This review article discusses the summary of methods for determining the concentration of chlorthalidone in pharmaceutical preparations and biological matrices. We took the data collected in this review article was taken through trusted sites such as Google Scholar with the search keywords "chlorthalidone determination," "pharmaceutical preparations," and "biological matrices," with a period of the last twenty years (2001-2021). This review article aims to provide an overview of the assay used to determine the concentration of chlorthalidone either in the form of a single substance or pharmaceutical dosage forms. Overall, the determination of chlorthalidone levels has been carried out using various analytical methods. Including spectrophotometry, high-performance liquid chromatography (HPLC), chemometrics and thin-layer chromatography (TLC) - densitometric, capillary zone electrophoresis (CZE) methods, spectrofluorimetric methods, liquid chromatography-mass spectrometry-mass spectrometry (LC-MS-MS) methods, ultrafast liquid chromatography (UFLC), supercritical fluid chromatography method and high-performance thin-layer chromatography (HPTLC)-densitometric method. Analysis with the HPLC technique is widely used in research because it can detect samples with the lowest concentrations up to the nanogram level.

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Section: High-performance Thin-layer Chromatography (Hptlc)mentioning

confidence: 99%

Review of Determination of Chlortalidone Levels in Pharmaceutical Preparations and Biological Matrix

Fitrizal¹,

Misfadhila²,

Rivai³

2021

IJPSM

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Electrochemical application of ZnCr2O4@MWCNTs-modified carbon paste electrode for sensing of chlorthalidone in its biological fluids

Abdel-Raoof,

Fouad,

Rashed

et al. 2023

J IRAN CHEM SOC

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Progress in Quantitative Methods for Azelnidipine and Chlorthalidone: An Analytical Basis for a Recently Approved FDC

Kotadiya

Raimalani

2023

CPA

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Backgroound: Products with multiple active substances mixed in a single dosage form are fixed-dose combinations. These are justified for a variety of reasons. These include a) increasing therapeutic efficacy, b) lowering adverse drug effects, c) pharmacokinetic advantages, d) lowering pill load, e) lowering individual drug doses, and f) lowering drug resistance development. Objective: A recently approved fixed dose combination of azelnidipine (8 mg) and chlorthalidone (6.25 or 12.5 mg) is indicated to treat hypertension. Individual quantification methods for azelnidipine and chlorthalidone are available, but no practical and acceptable analytical approach for their combination has been documented. As a result, the goal of this literature review was to gather information on the numerous analytical instrumental approaches utilized to quantify azelnidipine and chlorthalidone in diverse matrices individually. The scientific community could use this information to design a new analytical method for analysing the recently approved combination. Methods: Authors have explored various scientific databases to obtain information on analytical methods. Results: The methods listed for azelnidipine and chlorthalidone are spectroscopy, high-performance liquid chromatography, hyphenated techniques, high-performance thin-layer chromatography, thin-layer chromatography, and a few other approaches. For azelnidipine and chlorthalidone, there were 26 and 46 research papers reported, respectively.

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HPTLC-Densitometric Method for Simultaneous Estimation of Olmesartan medoxomil and Chlorthalidone in Tablet Dosage Form

Cited by 3 publications

References 14 publications

Review of Determination of Chlortalidone Levels in Pharmaceutical Preparations and Biological Matrix

Review of Determination of Chlortalidone Levels in Pharmaceutical Preparations and Biological Matrix

Electrochemical application of ZnCr2O4@MWCNTs-modified carbon paste electrode for sensing of chlorthalidone in its biological fluids

Progress in Quantitative Methods for Azelnidipine and Chlorthalidone: An Analytical Basis for a Recently Approved FDC

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