HPTLC-Densitometric Method for Determination of Eleutherosides B, E, and E1 in Different Eleutherococcus Species

Cieśla, Łukasz; Waksmundzka‐Hajnos, Monika; Załuski, Daniel; Smolarz, Helena D.; Hajnos, Michał

doi:10.1093/chrsci/49.3.182

Cited by 12 publications

(13 citation statements)

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“…They are one of the main ingredients of Chinese, Russian, and oriental (Korean and Japanese) system of medicine and also a popular tonic or adaptogen . Eleutherosides have been known and requested dietary supplements, and have also been included in the European Pharmacopeia as medicine . Since 1994, the Dietary Supplements Health and Education Act (DSHEA) and the Food and Drug Administration (FDA) regulation of the USA allowed direct distribution of eleutherosides .…”

Section: Eleutherosidesmentioning

confidence: 99%

Plant Adaptogens: Natural Medicaments for 21^stCentury?

et al. 2018

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This review is devoted to adaptogens, plant products capable of producing nonspecific responses in the human body, resulting in increasing the resistance against multiple stressors (physical, chemical or biological) and capable of having a normalizing effect to the human body. Adaptogens must be non-toxic, harmless, capable of not influencing normal body functions more than required, and capable of treating depression, a common neuropsychiatric illness, the importance of which is increasing by number of new patients every year. Number of plants are able to produce natural compounds, which meet the criteria of becoming adaptogens. The most known of them are used in traditional medicine for centuries.

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Section: Eleutherosidesmentioning

confidence: 99%

Plant Adaptogens: Natural Medicaments for 21^stCentury?

et al. 2018

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“…A special attention is given to eleutherosides B, E and E1, the compounds, which according to some authors, play a dominant role in the treatment of many diseases. Our previous phytochemical investigations have shown that eleutehrosides B, E and E1 are present in all the investigated species cultivated in Poland [1].…”

Section: Introductionmentioning

confidence: 81%

“…The chemical analysis performed by the authors has shown that the investigated species contain eleutherosides B and E, whose content is higher than the requirements of pharmacopoeia. Our earlier studies have shown that eleutherosides B, E and E1 are in all roots and fruits, but not in the leaves [1,2,17].…”

Section: Discussionmentioning

confidence: 99%

“…According to Załuski et al these compounds are present only in the roots and fruits. Using a validated HPTLC-densitometric method, it appeared that the roots of the investigated species have high eleutherosides content [1,16,18]. The amount of eleutheroside B ranged between 0.5 mg/g and 3.4 mg/g; eleutheroside E between 0.5 mg/g and 1.2 mg/g; and eleutheroside E1 between 0.2 and 0.9 mg/g of the sample, dry weight.…”

Section: Discussionmentioning

confidence: 99%

“…E. senticosus is also used in the treatment of bacterial and viral infections. In addition, it has been reported, that E. senticosus has antiinflammatory, immunostimulatory and immunomodulatory properties [1,[7][8][9]19].…”

Section: Current Issues In Pharmacy and Medical Sciencesmentioning

confidence: 99%

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Cytotoxic activity of ethanolic extracts of Eleutherococcus species cultivated in Poland on HL60 leukemia cell line

Załuski

Smolarz

Bogucka‐Kocka

2014

Current Issues in Pharmacy and Medical Sciences

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The Eleutherococcus species including 40 species native to Asia are medicinal plants widely used in traditional medicine. Some of these species are cultivated at the botanical gardens in Europe. On the basis on our earlier studies it was concluded that the extracts of analyzed species act as antioxidants, inhibitors of MMPs, and cytotoxic against Jurkat 45 leukemia cell line. In this study, the anti-leukemic potential of roots and leaves from six Eleutherococcus species cultivated in Poland was determined. The in vitro cytotoxic activity towards human promyelotic leukemia cell line HL60 using trypan blue assay was evaluated. The induction of apoptosis in stimulated leukemia cells was determined by AnnexinV method. Morphological changes in treated cells were observed by microscopic investigations. The results showed that ethanolic extracts from the roots and the leaves of E. senticosus, E. setchuensis, E. sessiliflorus, E.gracilistylus, E. henryi and E. divaricatus exhibit cytotoxic effect towards leukemic HL60 cells. The received IC50 values for roots ranged from 49-208 µg/mL and for the leaves from 116-518 µg/mL. The ethanol extract from the roots of E. divaricatus showed the highest cytotoxic and proapoptotic effect on HL60 human lymphoid leukemia cell line.

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Biotechnological production of eleutherosides: current state and perspectives

Murthy

Kim

Georgiev

et al. 2014

Appl Microbiol Biotechnol

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Eleutherosides, the phenylpropanoid and lignan glycosides, are the active ingredients accumulated in the roots and stems of Eleutherococcus species and in Eleutherococcus senticosus in particular. Syringin (=eleutheroside B) and (-) syringaresinol-di-O-β-D-glucoside (=eleutheroside E) appear as the most important bioactive compounds which are used as adaptogens, besides their abundant antidiabetic and anticancer properties. As the availability of "Eleuthero" is becoming increasingly limited because of its scanty natural distribution, the production of these compounds by biotechnological means has become an attractive alternative. In E. senticosus and other closely related species, Eleutherococcus sessiliflorus, Eleutherococcus chiisanensis, and Eleutherococcus koreanum, organogenic cultures have been induced for the production of eleutherosides. Bioreactor cultures have been established and various parameters, which influence on the accumulation of biomass and secondary metabolites, have been thoroughly investigated. Pilot-scale cultures have also been accomplished for the large-scale production of somatic embryos containing abundant amounts of eleutherosides. This review describes the biotechnological approaches and challenges for the production of eleutherosides.

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HPTLC-Densitometric Method for Determination of Eleutherosides B, E, and E1 in Different Eleutherococcus Species

Cited by 12 publications

References 12 publications

Plant Adaptogens: Natural Medicaments for 21^stCentury?

Plant Adaptogens: Natural Medicaments for 21^stCentury?

Cytotoxic activity of ethanolic extracts of Eleutherococcus species cultivated in Poland on HL60 leukemia cell line

Biotechnological production of eleutherosides: current state and perspectives

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HPTLC-Densitometric Method for Determination of Eleutherosides B, E, and E1 in Different Eleutherococcus Species

Cited by 12 publications

References 12 publications

Plant Adaptogens: Natural Medicaments for 21stCentury?

Plant Adaptogens: Natural Medicaments for 21stCentury?

Cytotoxic activity of ethanolic extracts of Eleutherococcus species cultivated in Poland on HL60 leukemia cell line

Biotechnological production of eleutherosides: current state and perspectives

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Product

Resources

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Plant Adaptogens: Natural Medicaments for 21^stCentury?

Plant Adaptogens: Natural Medicaments for 21^stCentury?