HPTLC and reverse phase HPLC methods for the simultaneous quantification and in vitro screening of antioxidant potential of isolated sesquiterpenoids from the rhizomes of Cyperus rotundus

Rani, Mubeen; Padmakumari, K. P.

doi:10.1016/j.jchromb.2012.05.042

Cited by 25 publications

(7 citation statements)

References 16 publications

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“…Previous studies have documented the anti‐fibrotic and hepatoprotective actions of β‐caryophyllene in pre‐clinical studies . Recent studies suggest that among several natural sesquiterpenes, NTK possesses superior reductive potential (reactive oxygen species [ROS] quenching capacity) and anti‐inflammatory properties . Moreover, NTK has been shown to mitigate multiple organ dysfunctions in animal model of sepsis, elicit anti‐platelet effect, and mitigate diet‐induced obesity .…”

Section: Introductionmentioning

confidence: 99%

Nootkatone confers hepatoprotective and anti‐fibrotic actions in a murine model of liver fibrosis by suppressing oxidative stress, inflammation, and apoptosis

Kurdi

Hassan

Venkataraman

et al. 2017

J Biochem & Molecular Tox

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In this study, the hepatoprotective and anti-fibrotic actions of nootkatone (NTK) were investigated using carbon tetrachloride (CCl )-induced liver fibrosis in mice. CCl administration elevated serum aspartate and alanine transaminases levels, respectively. In addition, CCl produced hepatic oxidative and nitrative stress, characterized by diminished hemeoxygenase-1 expression, antioxidant defenses, and accumulation of 4-hydroxynonenal and 3-nitrotyrosine. Furthermore, CCl administration evoked profound expression of pro-inflammatory cytokine expressions such as tumor necrosis factor-α, monocyte chemoattractant protein-1, and interleukin-1β in hepatic tissues, which corroborated with nuclear factor κB activation. Additionally, CCl -treated animals exhibited higher apoptosis, characterized by increased caspase 3 activity, DNA fragmentation, and poly (ADP-ribose) polymerase activation. Moreover, histological and biochemical investigations revealed marked fibrosis in the livers of CCl -administered animals. However, NTK treatment mitigated CCl -induced phenotypic changes. In conclusion, our findings suggest that NTK exerts hepatoprotective and anti-fibrotic actions by suppressing oxidative stress, inflammation, and apoptosis.

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Section: Introductionmentioning

confidence: 99%

Nootkatone confers hepatoprotective and anti‐fibrotic actions in a murine model of liver fibrosis by suppressing oxidative stress, inflammation, and apoptosis

Kurdi

Hassan

Venkataraman

et al. 2017

J Biochem & Molecular Tox

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“…This plant has recently attracted a great deal of attention due to the variety of chemical compositions and broad range of biological activities. The strong antioxidant properties of C. rotundus have been shown to be due to its polyphenol, terpene and essential oil contents (Kilani et al, 2008;Priya-Rani & Padmakumari, 2012;. It has also been reported that C. rotundus showed cytotoxic and apoptosis-inducing effects against various tumor cells (Kilani et al, 2008;Kilani-Jaziri et al, 2009;Sayed et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Inhibitors ofα-glucosidase andα-amylase fromCyperus rotundus

Tran

Nguyen

et al. 2013

Pharmaceutical Biology

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Context: A methanol extract of Cyperus rotundus L. (Cyperaceae) rhizomes showed inhibitory activity against a-glucosidase and a-amylase, two enzymes involve in carbohydrate digestion. Objective: Identification of compounds from C. rotundus rhizomes responsible for the inhibition of a-glucosidase and a-amylase. Materials and methods: Compounds were identified by a phytochemical investigation using combined chromatographic and spectroscopic methods. a-glucosidase and a-amylase inhibitory activities were evaluated by in vitro enzyme inhibition assays.0 ,5,6,7,8-hexahydroxyflavane (1), together with three known stilbene dimers cassigarol E (2), scirpusin A (3) and B (4) were isolated. Compound 2 inhibited both a-glucosidase and a-amylase activities while the flavane 1 only showed effect on a-amylase, and compounds 3 and 4 were active on a-glucosidase. All four compounds showed significant 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging activity. Discussion: The inhibitory activities against a-amylase and a-glucosidase of the C. rotundus rhizomes were reported for the first time. Stilbene dimers are considered as potent inhibitors of a-glucosidase and promising antihyperglycemic agents. Conclusion: The isolated compounds may contribute to the antidiabetic property of C. rotundus.

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“…In a phosphomolybdenum assay, it was indicated that 1 g of nootkatone possessed 15.83 mg of ascorbic acid activity. These findings suggested that nootkatone may provide the electrons and react with free radicals to generate a more stable product, eventually leading to termination of the free radical chain reaction . In another study, nootkatone showed protective action against oxidative stress in lipopolysaccharide (LPS)-stimulated BV2 microglial cells by inhibiting ROS production and increasing the activities of antioxidant enzymes, such as NAD(P)H:quinone oxidoreductase 1 (NQO1) and hemeoxygenase-1 (HO-1) .…”

Section: Biological Propertiesmentioning

confidence: 99%

“…These findings suggested that nootkatone may provide the electrons and react with free radicals to generate a more stable product, eventually leading to termination of the free radical chain reaction. 127 In another study, nootkatone showed protective action against oxidative stress in lipopolysaccharide (LPS)-stimulated BV2 microglial cells by inhibiting ROS production and increasing the activities of antioxidant enzymes, such as NAD(P)H:quinone oxidoreductase 1 (NQO1) and hemeoxygenase-1 (HO-1). 128 Moreover, Basappa et al 31 reported that the IC 50 value of A. indica Kuntze essential oil (9.86 μL mL −1 ) was close to that of the positive control butylated hydroxyl anisole (BHA; 7.03 μg mL −1 ), suggesting its strong free radical scavenging potential.…”

Section: Insecticidal Activitymentioning

confidence: 99%

Production, Function, and Applications of the Sesquiterpenes Valencene and Nootkatone: a Comprehensive Review

Zhang

Chen

et al. 2022

J. Agric. Food Chem.

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Valencene and nootkatone, two sesquiterpenes, extracted from natural sources, have great market potential with diverse applications. This paper aims to comprehensively review the recent advances in valencene and nootkatone, including source, production, physicochemical and biological properties, safety and pharmacokinetics evaluation, potential uses, and their industrial applications as well as future research directions. Microbial biosynthesis offers a promising alternative approach for sustainable production of valencene and nootkatone. Both compounds exert various beneficial activities, including antimicrobial, insecticidal, antioxidant, anti-inflammatory, anticancer, cardioprotective, neuroprotective, hepatoprotective, and nephroprotective and other activities. However, most of the studies are performed in animals and in vitro, making it difficult to give a conclusive description about their health benefits and extend their application. Hence, more attention should be paid to in vivo and long-term clinical studies in the future. Moreover, valencene and nootkatone are considered safe for consumption and show great promise in the applications of food, cosmetic, pharmaceutical, chemical, and agricultural industries.

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HPTLC and reverse phase HPLC methods for the simultaneous quantification and in vitro screening of antioxidant potential of isolated sesquiterpenoids from the rhizomes of Cyperus rotundus

Cited by 25 publications

References 16 publications

Nootkatone confers hepatoprotective and anti‐fibrotic actions in a murine model of liver fibrosis by suppressing oxidative stress, inflammation, and apoptosis

Nootkatone confers hepatoprotective and anti‐fibrotic actions in a murine model of liver fibrosis by suppressing oxidative stress, inflammation, and apoptosis

Inhibitors ofα-glucosidase andα-amylase fromCyperus rotundus

Production, Function, and Applications of the Sesquiterpenes Valencene and Nootkatone: a Comprehensive Review

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