HPTE-Induced Embryonic Thymocyte Death and Alteration of Differentiation Is Not Rescued by ERα or GPER Inhibition but Is Exacerbated by Concurrent TCR Signaling
Abstract:Organochlorine pesticides, such as DDT, methoxychlor, and their metabolites, have been characterized as endocrine disrupting chemicals (EDCs); suggesting that their modes of action involve interaction with or abrogation of endogenous endocrine function. This study examined whether embryonic thymocyte death and alteration of differentiation induced by the primary metabolite of methoxychlor, HPTE, rely upon estrogen receptor binding and concurrent T cell receptor signaling. Estrogen receptor inhibition of ERα or… Show more
“…The penetration of estrogens through lipid bilayers or their ability to adsorb to different materials is also examined by means of theoretical calculations. Avellaneda et al [13] studied the mechanisms underlying the effects of EDCs such as HPTE and DES on embryonic thymocyte death and differentiation. Their data suggest that the adverse effects on embryonic thymocytes induced by HPTE and DES are not only dependent on ERα or GPER, but probably both.…”
Many biological and physiological events, including growth, development, and metabolism of reproductive and non-reproductive tissues in men and women, are regulated by estrogens and estrogen receptors (ERs) [...]
“…The penetration of estrogens through lipid bilayers or their ability to adsorb to different materials is also examined by means of theoretical calculations. Avellaneda et al [13] studied the mechanisms underlying the effects of EDCs such as HPTE and DES on embryonic thymocyte death and differentiation. Their data suggest that the adverse effects on embryonic thymocytes induced by HPTE and DES are not only dependent on ERα or GPER, but probably both.…”
Many biological and physiological events, including growth, development, and metabolism of reproductive and non-reproductive tissues in men and women, are regulated by estrogens and estrogen receptors (ERs) [...]
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