2017
DOI: 10.1158/1535-7163.mct-15-0995
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HPMA–Copolymer Nanocarrier Targets Tumor-Associated Macrophages in Primary and Metastatic Breast Cancer

Abstract: Polymeric nanocarriers such as N-(2-hydroxypropyl) methacrylamide (HPMA) copolymers deliver drugs to solid tumors and avoid the systemic toxicity of conventional chemotherapy. Because HPMA copolymers can target sites of inflammation and accumulate within innate immune cells, we hypothesized that HPMA copolymers could target tumor-associated macrophages (TAMs) in both primary and metastatic tumor microenvironments. We verified this hypothesis, first in preliminary experiments with isolated bone marrow macrophag… Show more

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Cited by 24 publications
(9 citation statements)
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“…Its magnetic core makes it possible for utilization in the diagnosis as it is detected by MRI on injection to tissues. On one side, where Poly-L-glutamic acid (PLGA; a synthetic biodegradable polymer) is employed for conjugate synthesis, polyethylene glycol (PEG) and N-(2-hydroxypropyl)-methacryl amide copolymer (HPMA) are the most widely used non-biodegradable polymers of synthetic origin [40][41][42][43]. PLGA (Poly-(lactic-co-glycolic acid) nanoencapsulated with Callistemon citrinus phenolics exhibited anticancer properties against BC cell lines viz.…”
Section: Polymeric-based Nanoparticlesmentioning
confidence: 99%
“…Its magnetic core makes it possible for utilization in the diagnosis as it is detected by MRI on injection to tissues. On one side, where Poly-L-glutamic acid (PLGA; a synthetic biodegradable polymer) is employed for conjugate synthesis, polyethylene glycol (PEG) and N-(2-hydroxypropyl)-methacryl amide copolymer (HPMA) are the most widely used non-biodegradable polymers of synthetic origin [40][41][42][43]. PLGA (Poly-(lactic-co-glycolic acid) nanoencapsulated with Callistemon citrinus phenolics exhibited anticancer properties against BC cell lines viz.…”
Section: Polymeric-based Nanoparticlesmentioning
confidence: 99%
“…Therefore, routine ferumoxytol assessments in cancer patients may provide predictive data regarding passive targeting and tumor cell/TAM uptake (see below) and therefore, allow the stratification of patients for PT treatment. Interestingly, a study has described TAM-specific targeting in primary and metastatic breast cancer using HPMA-copolymer nanocarriers as a possible therapeutic approach [ 117 ].…”
Section: Hurdle 2: Targeting the Tumor And Tumor Uptakementioning
confidence: 99%
“…MDA-MB-231 cells used in xenograft studies were obtained from NCI NIH (Bethesda, MD). Luciferase-labeled 4T1 cells were described previously 80 , as were luciferase- and GFP-labeled 4T1 cells 81 . The 4T1 cells’ overexpression Id1 were derived by transducing cells with pBabe- Id1 plasmids as described previously 47 .…”
Section: Methodsmentioning
confidence: 99%