HPLC‐UV analysis of bupropion and hydroxybupropion: Application to in vivo pharmacokinetic drug‐drug interaction studies between bupropion and potent CYP2B6 inhibitors
Abstract:Bupropion is a popular antidepressant that is also prescribed in the management of smoking cessation. In humans, bupropion is predominantly metabolized to its active metabolite hydroxybupropion by CYP2B6. Inhibitors of CYP2B6 have the potential to decrease the clearance of bupropion, leading to adverse drug toxicity. We sought to develop a sensitive HPLC‐UV assay to quantify plasma and brain concentrations of bupropion and hydroxybupropion; and apply the assay to assess in vivo pharmacokinetic (PK) drug‐drug i… Show more
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