HPLC quantitation of kaurane diterpenes in Xylopia species

Melo, Angelita Cristine de; Cota, Betânia Barros; Oliveira, Alaı́de Braga de; Braga, Fernão Castro

doi:10.1016/s0367-326x(00)00251-3

Cited by 24 publications

(14 citation statements)

References 10 publications

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“…In addition, a general survey and some taxonomic implications of the occurrence of kaurane and other classes of diterpenes in the Asteraceae family are discussed by Alvarenga and collaborators [39]. Kaurenoic acid (1), an ent-kaurane diterpene that possesses a wide spectrum of bioactivities such as antiinflammatory, antibacterial, antifungal and moluscical properties, among others [6], is not commercially available, but it is relatively abundant in some species belonging to the Wedelia [40], Mikania [41], Annona [42] and Xylopia [43] genera, which has motivated its quantification in these plant species [42][43][44][45][46][47], enabling the use of all of them as natural sources of this diterpene. Figure 3.…”

Section: Taxanes Tiglianesmentioning

confidence: 99%

Occurrence, Biological Activities and Synthesis of Kaurane Diterpenes and their Glycosides

2007

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This paper presents a review on kaurane diterpenes and their glycoside derivatives, covering aspects of their occurrence, biological activities and the synthesis of these natural products and their analogues. First, it shows and classifies diterpenes, in accordance with the already established structural criteria in the literature. Then, kaurane diterpenes are presented, focusing on their chemical structures, occurrence in the plant kingdom and their main, recently described, biological activities. Moreover, the most significant works, published between 1964 and November 2006, which describe the total synthesis or structural transformations of some kaurane diterpenes, including either semisynthetic and/or microbiological methodologies, are consisely reviewed. At this point, some general considerations on glycosides are introduced, and kaurane glycosides are presented and discussed on the basis of their toxic importance and occurrence in the plant kingdom, having focused on related aspects of their biological activities and the relationships between these activities and the structural factors of their molecules. Finally, the principal methods of glycosidation by enzymatic and chemical processes are both presented, and a few papers on the synthesis of kaurane glycosides are succinctly discussed. Molecules 2007, 12 456

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Section: Taxanes Tiglianesmentioning

confidence: 99%

Occurrence, Biological Activities and Synthesis of Kaurane Diterpenes and their Glycosides

2007

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“…A espécie Xylopia brasiliensis Sprengel, vulgarmente conhecida como pindaíba, recebeu atenção em estudos com abordagem fitossociológica e fitoquímica, entre outros (Leboeuf et al 1982;Dias & Oliveira-Filho 1996;Oliveira-Filho et al 1997;Moreira et al 2003;Oliveira-Filho & Fluminhan-Filho 1999;Rondon Neto et al 2000;Vilela et al 2000;Melo et al 2001;Salimon & Negrelle 2001). Os indivíduos juvenis de X. brasiliensis geralmente formam vigorosa população no sub-bosque das florestas semi-decíduas do sul de Minas Gerais, sugerindo tratarse de uma espécie clímax tolerante à sombra (OliveiraFilho et al 1996), embora Lorenzi (1992) classifique a espécie como heliófila ou mesmo pioneira.…”

Section: Introductionunclassified

Plasticidade anatômica das folhas de Xylopia brasiliensis Sprengel (Annonaceae)

et al. 2005

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RESUMO -(Plasticidade anatômica das folhas de Xylopia brasiliensis Sprengel (Annonaceae)). A anatomia foliar do gênero Xylopia ainda é pouco explorada. A espécie Xylopia brasiliensis Sprengel, vulgarmente conhecida como pindaíba, ocorre tanto em mata primária como em vegetação modificada num amplo espectro de condições ambientais. O presente estudo descreve algumas características anatômicas da folha de X. brasiliensis e avalia quantitativamente o limbo foliar em função das diferenças ambientais, sazonais e de estatura das plantas. Verificou-se que a espécie apresenta plasticidade anatômica.Palavras-chave : anatomia foliar, sombreamento, pindaíba, mata secundária, sub-bosque ABSTRACT -(Leaf anatomical plasticity of Xylopia brasiliensis Sprengel (Annonaceae)). Leaf anatomy of Xylopia is still poorly explored. The species Xylopia brasiliensis Sprengel, commonly known as pindaíba occurs in primary forest and in modified vegetation in a wide range of environmental conditions. The present study describes some leaf anatomical characteristics of this species and quantitatively evaluates them in function of environmental, seasonal and plant height differences. This species has anatomical plasticity.

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“…With this purpose, its content has been previously assayed in species of Xylopia (Annonaceae) (Melo et al, 2001), Rabdosia (Lamiaceae) (Kubo et al, 1982) and in Annona glabra (Annonaceae) , by HPLC methods. Furthermore, kaurenoic acid (1) has been determined by GC methods in Asteraceae species, including Mikania glomerata (Vilegas et al, 1997) and Wedelia paludosa (Bresciani et al, 2000;Bresciani et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

Quantitative determination by HPLC of ent-kaurenoic and grandiflorenic acids in aerial parts of Wedelia paludosa D.C.

Batista¹,

Braga²,

Oliveira³

2005

Rev. bras. farmacogn.

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There are several reports of biological activity for kaurenoic acid (1), which is found in the aerial parts of Wedelia paludosa D.C., a herbaceous plant of the Asteraceae family abundant in Brazil, and that contains grandifl orenic acid (2) also. Both of these diterpenes were shown to cause lysis of trypomastigotes of the protozoa Trypanosoma cruzi, the causative agent of Chagas' disease (American trypanosomiasis). This paper reports the quantitative determination of these diterpene acids in the aerial parts of W. paludosa by an isocratic RP-HPLC method employing 60% acetonitrile in water and UV detection (220 nm). Kaurenoic acid (1) was found to be more abundant (0.85 ± 0.08%) while the amount of grandifl orenic acid (2) determined was almost three times lower (0.32 ± 0.02%). No signifi cant seasonal variation was observed for these compounds in W. paludosa growing in Belo Horizonte (MG, Brazil) what points out to the aerial parts of this species are a good source of these biologically active diterpenes along all the year.

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HPLC quantitation of kaurane diterpenes in Xylopia species

Cited by 24 publications

References 10 publications

Occurrence, Biological Activities and Synthesis of Kaurane Diterpenes and their Glycosides

Occurrence, Biological Activities and Synthesis of Kaurane Diterpenes and their Glycosides

Plasticidade anatômica das folhas de Xylopia brasiliensis Sprengel (Annonaceae)

Quantitative determination by HPLC of ent-kaurenoic and grandiflorenic acids in aerial parts of Wedelia paludosa D.C.

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