HPLC-profiling for antiplasmodial compounds—3-Methoxycarpachromene from Pistacia atlantica

Adams, Michael; Plitzko, Inken; Kaiser, Marcel; Brun, Reto; Hamburger, Matthias

doi:10.1016/j.phytol.2009.05.006

Cited by 31 publications

(25 citation statements)

References 13 publications

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“…As reported by Adams et al [55], the leaves and twigs of P. atlantica and its active substance 3-methoxycarpachromene showed antiprotozoal activity against Plasmodium falciparum . P. atlantica var.…”

Section: Pharmacological Aspectsmentioning

confidence: 59%

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Five Pistacia species (P. vera, P. atlantica, P. terebinthus, P. khinjuk, and P. lentiscus): A Review of Their Traditional Uses, Phytochemistry, and Pharmacology

Bozorgi

Memariani

Mobli

et al. 2013

The Scientific World Journal

252

179

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Pistacia, a genus of flowering plants from the family Anacardiaceae, contains about twenty species, among them five are more popular including P. vera, P. atlantica, P. terebinthus, P. khinjuk, and P. lentiscus. Different parts of these species have been used in traditional medicine for various purposes like tonic, aphrodisiac, antiseptic, antihypertensive and management of dental, gastrointestinal, liver, urinary tract, and respiratory tract disorders. Scientific findings also revealed the wide pharmacological activities from various parts of these species, such as antioxidant, antimicrobial, antiviral, anticholinesterase, anti-inflammatory, antinociceptive, antidiabetic, antitumor, antihyperlipidemic, antiatherosclerotic, and hepatoprotective activities and also their beneficial effects in gastrointestinal disorders. Various types of phytochemical constituents like terpenoids, phenolic compounds, fatty acids, and sterols have also been isolated and identified from different parts of Pistacia species. The present review summarizes comprehensive information concerning ethnomedicinal uses, phytochemistry, and pharmacological activities of the five mentioned Pistacia species.

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Section: Pharmacological Aspectsmentioning

confidence: 59%

“…Flavonoids were also isolated from aerial parts of P. atlantica and P. lentiscus, and quercetin-3-glucoside ( 56 ) was reported as the most abundant one [54]. 3-Methoxycarpachromene ( 57 ), a flavone with antiplasmodial activity, was isolated from aerial parts of P. atlantica [55]. …”

Section: Phytochemical Studiesmentioning

confidence: 99%

Five Pistacia species (P. vera, P. atlantica, P. terebinthus, P. khinjuk, and P. lentiscus): A Review of Their Traditional Uses, Phytochemistry, and Pharmacology

Bozorgi

Memariani

Mobli

et al. 2013

The Scientific World Journal

252

179

View full text Add to dashboard Cite

show abstract

“…Follow-up of active extracts was by HPLC-based activity profiling to identify the active constituents [9]. We recently adapted and validated this approach for the miniaturized and efficient identification of antiprotozoal compounds in complex plant and fungal extracts [10] and have successfully applied it to discovery of new antiprotozoal natural products in other library-based discovery projects [11–17]. …”

Section: Introductionmentioning

confidence: 99%

Screening and HPLC-Based Activity Profiling for New Antiprotozoal Leads from European Plants

Zimmermann

Thomi²,

Kaiser

et al. 2012

Sci. Pharm.

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Based on a survey of remedies used in Renaissance Europe to treat malaria, we prepared and screened a library of 254 extracts from 61 plants for antiplasmodial activity in vitro. HPLC-based activity profiling was performed for targeted identification of active constituents in extracts. One of the most remarkable results was the identification of onopordopicrin, a germacranolide sesquiterpene lactone isolated from Arctium nemorosum as a potent inhibitor of P. falciparum with an IC50 of 6.9 μM. It was tested similarly against Trypanosoma brucei rhodesiense, the parasite which causes African sleeping sickness. With an IC50 of 0.37 μM, onopordopicrin was one of the most potent natural products reported so far. Cytotoxicity was determined against rat myoblast L6 cells (IC50: 3.06).

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“…Previously we reported remedies used to treat dementia (Adams and Hamburger, 2007), rheumatism (Adams et al, 2009a), and malaria (Adams et al, 2011a). These studies form the basis for the focused selection of plants to be screened against targets relevant to each of the indications to identify their active constituents (Adams et al, 2009b(Adams et al, ,c, 2011bZimmermann et al, 2012a,b).…”

Section: Introductionmentioning

confidence: 99%

Epilepsy in the Renaissance: A survey of remedies from 16th and 17th century German herbals

Adams

Schneider

Kluge

et al. 2012

Journal of Ethnopharmacology

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HPLC-profiling for antiplasmodial compounds—3-Methoxycarpachromene from Pistacia atlantica

Cited by 31 publications

References 13 publications

Five Pistacia species (P. vera, P. atlantica, P. terebinthus, P. khinjuk, and P. lentiscus): A Review of Their Traditional Uses, Phytochemistry, and Pharmacology

Five Pistacia species (P. vera, P. atlantica, P. terebinthus, P. khinjuk, and P. lentiscus): A Review of Their Traditional Uses, Phytochemistry, and Pharmacology

Screening and HPLC-Based Activity Profiling for New Antiprotozoal Leads from European Plants

Epilepsy in the Renaissance: A survey of remedies from 16th and 17th century German herbals

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